| UniProt ID | RDH10_HUMAN | |
|---|---|---|
| UniProt AC | Q8IZV5 | |
| Protein Name | Retinol dehydrogenase 10 | |
| Gene Name | RDH10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 341 | |
| Subcellular Localization |
Microsome membrane Single-pass membrane protein . Endoplasmic reticulum membrane Single-pass membrane protein . |
|
| Protein Description | Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.. | |
| Protein Sequence | MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 121 | Ubiquitination | TYTCDVGKRENVYLT EEECCCCCCEEEEEE | 57.28 | 21906983 | |
| 126 | Phosphorylation | VGKRENVYLTAERVR CCCCEEEEEEEHHHH | 15.21 | 28152594 | |
| 128 | Phosphorylation | KRENVYLTAERVRKE CCEEEEEEEHHHHHH | 14.58 | 28152594 | |
| 134 | Ubiquitination | LTAERVRKEVGEVSV EEEHHHHHHHCCEEE | 54.62 | 21890473 | |
| 177 | Phosphorylation | CHAHFWTTKAFLPTM CCCEEEHHHCHHHHE | 15.80 | 25690035 | |
| 229 | Ubiquitination | ESLSHELKAAEKDGI HHHHHHHHHHHHCCC | 42.43 | - | |
| 248 | Phosphorylation | VCPYLVDTGMFRGCR ECCCEECCCCCCCCC | 24.06 | - | |
| 268 | Ubiquitination | EPFLPPLKPDYCVKQ CCCCCCCCCCHHHHH | 41.43 | - | |
| 268 | Acetylation | EPFLPPLKPDYCVKQ CCCCCCCCCCHHHHH | 41.43 | 27452117 | |
| 274 | Ubiquitination | LKPDYCVKQAMKAIL CCCCHHHHHHHHHHH | 28.86 | - | |
| 274 | Acetylation | LKPDYCVKQAMKAIL CCCCHHHHHHHHHHH | 28.86 | 27452117 | |
| 282 | Phosphorylation | QAMKAILTDQPMICT HHHHHHHCCCCCCCC | 26.86 | 26074081 | |
| 289 | Phosphorylation | TDQPMICTPRLMYIV CCCCCCCCHHHHHHH | 10.66 | 26074081 | |
| 294 | Phosphorylation | ICTPRLMYIVTFMKS CCCHHHHHHHHHHHH | 9.24 | 24719451 | |
| 297 | Phosphorylation | PRLMYIVTFMKSILP HHHHHHHHHHHHCCC | 14.41 | 24719451 | |
| 319 | Ubiquitination | YRFLGADKCMYPFIA HHHHCCCHHHHHHHH | 21.99 | 21906983 | |
| 322 | Phosphorylation | LGADKCMYPFIAQRK HCCCHHHHHHHHHHH | 12.40 | 25884760 | |
| 338 | Ubiquitination | ATNNNEAKNGI---- HCCCHHHHCCC---- | 49.91 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RDH10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RDH10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RDH10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ERGI1_HUMAN | ERGIC1 | physical | 27173435 | |
| RB39A_HUMAN | RAB39A | physical | 27173435 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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