PXL1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PXL1_ARATH
• UniProt AC: Q9FRS6
• Protein Name: Leucine-rich repeat receptor-like protein kinase PXL1
• Gene Name: PXL1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1029
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Involved in the regulation of procambium maintenance and polarity during vascular-tissue development. [PubMed: 17570668 Phosphorylates HIRD11 and LHCA1 in vitro]
• Protein Sequence: MAIPRLFFLFYYIGFALFPFVSSETFQNSEQEILLAFKSDLFDPSNNLQDWKRPENATTFSELVHCHWTGVHCDANGYVAKLLLSNMNLSGNVSDQIQSFPSLQALDLSNNAFESSLPKSLSNLTSLKVIDVSVNSFFGTFPYGLGMATGLTHVNASSNNFSGFLPEDLGNATTLEVLDFRGGYFEGSVPSSFKNLKNLKFLGLSGNNFGGKVPKVIGELSSLETIILGYNGFMGEIPEEFGKLTRLQYLDLAVGNLTGQIPSSLGQLKQLTTVYLYQNRLTGKLPRELGGMTSLVFLDLSDNQITGEIPMEVGELKNLQLLNLMRNQLTGIIPSKIAELPNLEVLELWQNSLMGSLPVHLGKNSPLKWLDVSSNKLSGDIPSGLCYSRNLTKLILFNNSFSGQIPEEIFSCPTLVRVRIQKNHISGSIPAGSGDLPMLQHLELAKNNLTGKIPDDIALSTSLSFIDISFNHLSSLSSSIFSSPNLQTFIASHNNFAGKIPNQIQDRPSLSVLDLSFNHFSGGIPERIASFEKLVSLNLKSNQLVGEIPKALAGMHMLAVLDLSNNSLTGNIPADLGASPTLEMLNVSFNKLDGPIPSNMLFAAIDPKDLVGNNGLCGGVLPPCSKSLALSAKGRNPGRIHVNHAVFGFIVGTSVIVAMGMMFLAGRWIYTRWDLYSNFAREYIFCKKPREEWPWRLVAFQRLCFTAGDILSHIKESNIIGMGAIGIVYKAEVMRRPLLTVAVKKLWRSPSPQNDIEDHHQEEDEEDDILREVNLLGGLRHRNIVKILGYVHNEREVMMVYEYMPNGNLGTALHSKDEKFLLRDWLSRYNVAVGVVQGLNYLHNDCYPPIIHRDIKSNNILLDSNLEARIADFGLAKMMLHKNETVSMVAGSYGYIAPEYGYTLKIDEKSDIYSLGVVLLELVTGKMPIDPSFEDSIDVVEWIRRKVKKNESLEEVIDASIAGDCKHVIEEMLLALRIALLCTAKLPKDRPSIRDVITMLAEAKPRRKSVCQVAGDLPIFRNSPVVGLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	N-linked_Glycosylation	QDWKRPENATTFSEL CCCCCCCCCCCHHHH	45.32	-
88	N-linked_Glycosylation	KLLLSNMNLSGNVSD HHHHHCCCCCCCHHH	34.99	-
92	N-linked_Glycosylation	SNMNLSGNVSDQIQS HCCCCCCCHHHHHHH	27.09	-
123	N-linked_Glycosylation	SLPKSLSNLTSLKVI CCCHHHHCCCCCEEE	53.27	-
155	N-linked_Glycosylation	ATGLTHVNASSNNFS CCCCCEEECCCCCCC	26.88	-
160	N-linked_Glycosylation	HVNASSNNFSGFLPE EEECCCCCCCCCCCH	34.11	-
171	N-linked_Glycosylation	FLPEDLGNATTLEVL CCCHHHCCCEEEEEE	41.22	-
256	N-linked_Glycosylation	YLDLAVGNLTGQIPS HHHHHCCCCCCCCCC	28.03	-
390	N-linked_Glycosylation	SGLCYSRNLTKLILF CCCEECCCCCEEEEE	46.23	-
398	N-linked_Glycosylation	LTKLILFNNSFSGQI CCEEEEECCCCCCCC	39.53	-
448	N-linked_Glycosylation	HLELAKNNLTGKIPD HHHHHHCCCCCCCCC	37.97	-
565	N-linked_Glycosylation	LAVLDLSNNSLTGNI EEEEECCCCCCCCCC	49.78	-
586	N-linked_Glycosylation	SPTLEMLNVSFNKLD CCCEEHHEECCCCCC	26.52	-
706	Phosphorylation	AFQRLCFTAGDILSH HHHHHHCHHHHHHHH	28.83	-
801	Phosphorylation	EREVMMVYEYMPNGN CCEEEEEEEECCCCC	5.39	-
841	Phosphorylation	GVVQGLNYLHNDCYP HHHHHHHHHCCCCCC	17.87	-
887	Phosphorylation	LHKNETVSMVAGSYG HCCCCCEEEECCCCC	18.24	-
895	Phosphorylation	MVAGSYGYIAPEYGY EECCCCCEECCCCCE	5.91	-
902	Phosphorylation	YIAPEYGYTLKIDEK EECCCCCEEEEECCC	14.16	-
903	Phosphorylation	IAPEYGYTLKIDEKS ECCCCCEEEEECCCC	19.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PXL1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PXL1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PXL1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAM74_ARATH	AT5G59650	physical	21423366
PXL1_ARATH	AT1G08590	physical	25602612
CAB6_ARATH	LHCA1	physical	25602612
CDPK5_ARATH	CPK5	physical	25602612
HAT4_ARATH	HB-2	physical	25602612
PSAB_ARATH	psaB	physical	25602612
R37A2_ARATH	AT3G60245	physical	25602612
PSBR_ARATH	PSBR	physical	25602612
CA4_ARATH	LHCA4	physical	25602612
APS1_ARATH	APS1	physical	25602612
Y2766_ARATH	AT2G37660	physical	25602612
HHP2_ARATH	HHP2	physical	24833385
UBC32_ARATH	UBC32	physical	24833385
UBC34_ARATH	UBC34	physical	24833385
ACBP6_ARATH	ACBP6	physical	24833385
TRXH3_ARATH	TRX3	physical	24833385
PLCD2_ARATH	PLC2	physical	24833385
MSBP2_ARATH	MAPR3	physical	24833385
WAK3_ARATH	WAK3	physical	24833385
PAM74_ARATH	AT5G59650	physical	24833385
BETL2_ARATH	AT1G29060	physical	24833385
BET12_ARATH	ATBET12	physical	24833385
VAP21_ARATH	AT5G47180	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.