UniProt ID | PLCD2_ARATH | |
---|---|---|
UniProt AC | Q39033 | |
Protein Name | Phosphoinositide phospholipase C 2 | |
Gene Name | PLC2 | |
Organism | Arabidopsis thaliana (Mouse-ear cress). | |
Sequence Length | 581 | |
Subcellular Localization |
Cell membrane Peripheral membrane protein . |
|
Protein Description | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. At physiological calcium concentration, the preferred substrate is phosphatidylinositol 4,5-bisphosphate versus phosphatidylinositol.. | |
Protein Sequence | MSKQTYKVCFCFRRRFRYTASEAPREIKTIFEKYSENGVMTVDHLHRFLIDVQKQDKATREDAQSIINSASSLLHRNGLHLDAFFKYLFGDNNPPLALHKVHHDMDAPISHYFIFTGHNSYLTGNQLSSDCSEVPIIDALKKGVRVIELDIWPNSNKDDIDVLHGMTLTTPVGLIKCLKAIRAHAFDVSDYPVVVTLEDHLTPDLQSKVAEMVTEIFGEILFTPPVGESLKEFPSPNSLKRRIIISTKPPKEYKEGKDVEVVQKGKDLGDEEVWGREVPSFIQRNKSEAKDDLDGNDDDDDDDDEDKSKINAPPQYKHLIAIHAGKPKGGITECLKVDPDKVRRLSLSEEQLEKAAEKYAKQIVRFTQHNLLRIYPKGTRVTSSNYNPLVGWSHGAQMVAFNMQGYGRSLWLMQGMFRANGGCGYIKKPDLLLKSGSDSDIFDPKATLPVKTTLRVTVYMGEGWYFDFRHTHFDQYSPPDFYTRVGIAGVPGDTVMKKTKTLEDNWIPAWDEVFEFPLTVPELALLRLEVHEYDMSEKDDFGGQTCLPVWELSEGIRAFPLHSRKGEKYKSVKLLVKVEFV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
29 | Phosphorylation | EAPREIKTIFEKYSE CCCHHHHHHHHHHHH | 36.24 | 19880383 | |
280 | Phosphorylation | VWGREVPSFIQRNKS HCCCCCHHHHHHCHH | 39.91 | 30291188 | |
287 | Phosphorylation | SFIQRNKSEAKDDLD HHHHHCHHHCCCCCC | 46.46 | 20374526 | |
332 | Phosphorylation | GKPKGGITECLKVDP CCCCCCCEECEECCH | 24.74 | 25561503 | |
346 | Phosphorylation | PDKVRRLSLSEEQLE HHHHHHHCCCHHHHH | 28.21 | 30291188 | |
348 | Phosphorylation | KVRRLSLSEEQLEKA HHHHHCCCHHHHHHH | 35.39 | 25561503 | |
437 | Phosphorylation | DLLLKSGSDSDIFDP CEEEECCCCCCCCCC | 40.82 | 25561503 | |
439 | Phosphorylation | LLKSGSDSDIFDPKA EEECCCCCCCCCCCC | 34.01 | 25561503 | |
471 | Phosphorylation | WYFDFRHTHFDQYSP EEEEEECCCCCCCCC | 21.71 | 25368622 | |
476 | Phosphorylation | RHTHFDQYSPPDFYT ECCCCCCCCCCCHHH | 25.62 | 25368622 | |
477 | Phosphorylation | HTHFDQYSPPDFYTR CCCCCCCCCCCHHHH | 25.07 | 25368622 | |
482 | Phosphorylation | QYSPPDFYTRVGIAG CCCCCCHHHHCEECC | 10.87 | 25368622 | |
545 | Phosphorylation | KDDFGGQTCLPVWEL CCCCCCCCCEEHEEC | 21.20 | 23111157 | |
553 | Phosphorylation | CLPVWELSEGIRAFP CEEHEECCCCEEEEE | 23.43 | 23111157 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PLCD2_ARATH !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PLCD2_ARATH !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PLCD2_ARATH !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Y1756_ARATH | AT1G07560 | physical | 21423366 | |
ACA12_ARATH | AT3G63380 | physical | 21423366 | |
MLO2_ARATH | MLO2 | physical | 21423366 | |
WAXS6_ARATH | AT5G55330 | physical | 21423366 | |
TET11_ARATH | TET11 | physical | 21423366 | |
Y5838_ARATH | BIR1 | physical | 21423366 | |
Y3804_ARATH | AT3G28040 | physical | 21423366 | |
Y5639_ARATH | AT5G63930 | physical | 21423366 | |
Y5129_ARATH | AT5G10290 | physical | 21423366 | |
Y2289_ARATH | AT2G28960 | physical | 21423366 | |
PXC3_ARATH | AT2G41820 | physical | 21423366 | |
HA22J_ARATH | HVA22J | physical | 21423366 | |
Y2899_ARATH | AT2G28990 | physical | 21423366 | |
C83A1_ARATH | CYP83A1 | physical | 21423366 | |
Y4052_ARATH | AT4G30520 | physical | 21423366 | |
AUX1_ARATH | AUX1 | physical | 21423366 | |
RC21_ARATH | AT1G57550 | physical | 21423366 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of plasma membrane proteinsreveals regulatory mechanisms of plant innate immune responses."; Nuehse T.S., Bottrill A.R., Jones A.M.E., Peck S.C.; Plant J. 51:931-940(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280, AND MASSSPECTROMETRY. | |
"Temporal analysis of sucrose-induced phosphorylation changes inplasma membrane proteins of Arabidopsis."; Niittylae T., Fuglsang A.T., Palmgren M.G., Frommer W.B.,Schulze W.X.; Mol. Cell. Proteomics 6:1711-1726(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280, AND MASSSPECTROMETRY. | |
"Phosphoproteomics of the Arabidopsis plasma membrane and a newphosphorylation site database."; Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.; Plant Cell 16:2394-2405(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280, AND MASSSPECTROMETRY. |