CDPK5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDPK5_ARATH
• UniProt AC: Q38871
• Protein Name: Calcium-dependent protein kinase 5
• Gene Name: CPK5
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 556
• Subcellular Localization: Membrane ; Lipid-anchor .
• Protein Description: May play a role in signal transduction pathways that involve calcium as a second messenger..
• Protein Sequence: MGNSCRGSFKDKLDEGDNNKPEDYSKTSTTNLSSNSDHSPNAADIIAQEFSKDNNSNNNSKDPALVIPLREPIMRRNPDNQAYYVLGHKTPNIRDIYTLSRKLGQGQFGTTYLCTEIASGVDYACKSISKRKLISKEDVEDVRREIQIMHHLAGHGSIVTIKGAYEDSLYVHIVMELCAGGELFDRIIQRGHYSERKAAELTKIIVGVVEACHSLGVMHRDLKPENFLLVNKDDDFSLKAIDFGLSVFFKPGQIFTDVVGSPYYVAPEVLLKRYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGYIDFESDPWPVISDSAKDLIRRMLSSKPAERLTAHEVLRHPWICENGVAPDRALDPAVLSRLKQFSAMNKLKKMALKVIAESLSEEEIAGLREMFQAMDTDNSGAITFDELKAGLRKYGSTLKDTEIHDLMDAADVDNSGTIDYSEFIAATIHLNKLEREEHLVAAFQYFDKDGSGFITIDELQQACVEHGMADVFLEDIIKEVDQNNDGKIDYGEFVEMMQKGNAGVGRRTMRNSLNISMRDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNSCRGSF ------CCCCCCCCH	34.46	-
8	Phosphorylation	MGNSCRGSFKDKLDE CCCCCCCCHHCCCCC	15.12	30291188
27	Phosphorylation	KPEDYSKTSTTNLSS CCCCCCCCCCCCCCC	25.93	23111157
28	Phosphorylation	PEDYSKTSTTNLSSN CCCCCCCCCCCCCCC	36.65	30407730
29	Phosphorylation	EDYSKTSTTNLSSNS CCCCCCCCCCCCCCC	25.57	30407730
30	Phosphorylation	DYSKTSTTNLSSNSD CCCCCCCCCCCCCCC	33.65	30407730
33	Phosphorylation	KTSTTNLSSNSDHSP CCCCCCCCCCCCCCC	29.55	23111157
34	Phosphorylation	TSTTNLSSNSDHSPN CCCCCCCCCCCCCCC	43.44	26811356
36	Phosphorylation	TTNLSSNSDHSPNAA CCCCCCCCCCCCCHH	38.35	23111157
39	Phosphorylation	LSSNSDHSPNAADII CCCCCCCCCCHHHHH	25.49	23111157
56	Phosphorylation	EFSKDNNSNNNSKDP HHHCCCCCCCCCCCC	47.38	25561503
60	Phosphorylation	DNNSNNNSKDPALVI CCCCCCCCCCCCEEE	40.33	25561503
261	Phosphorylation	IFTDVVGSPYYVAPE EEECCCCCCCEECHH	9.71	-
544	Phosphorylation	NAGVGRRTMRNSLNI CCCCCHHHHHHHHCC	21.08	23776212
548	Phosphorylation	GRRTMRNSLNISMRD CHHHHHHHHCCCCCC	16.66	30291188
552	Phosphorylation	MRNSLNISMRDA--- HHHHHCCCCCCC---	13.49	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDPK5_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDPK5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDPK5_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of CDPK5_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, AND MASSSPECTROMETRY.
PubMed: 19376835

"A phyloproteomic characterization of in vitro autophosphorylation incalcium-dependent protein kinases.";
Hegeman A.D., Rodriguez M., Han B.W., Uno Y., Phillips G.N. Jr.,Hrabak E.M., Cushman J.C., Harper J.F., Harmon A.C., Sussman M.R.;
Proteomics 6:3649-3664(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8, AND MASSSPECTROMETRY.
PubMed: 16758442