UniProt ID | PROZ_HUMAN | |
---|---|---|
UniProt AC | P22891 | |
Protein Name | Vitamin K-dependent protein Z | |
Gene Name | PROZ | |
Organism | Homo sapiens (Human). | |
Sequence Length | 400 | |
Subcellular Localization | Secreted. | |
Protein Description | Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.. | |
Protein Sequence | MAGCVPLLQGLVLVLALHRVEPSVFLPASKANDVLVRWKRAGSYLLEELFEGNLEKECYEEICVYEEAREVFENEVVTDEFWRRYKGGSPCISQPCLHNGSCQDSIWGYTCTCSPGYEGSNCELAKNECHPERTDGCQHFCLPGQESYTCSCAQGYRLGEDHKQCVPHDQCACGVLTSEKRAPDLQDLPWQVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRNITVKTYFNRTSQDPLMIKITHVHVHMRYDADAGENDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSLTTRPVTLVEGEECGQVLNVTVTTRTYCERSSVAAMHWMDGSVVTREHRGSWFLTGVLGSQPVGGQAHMVLVTKVSRYSLWFKQIMN | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
47 | 4-carboxyglutamate | RAGSYLLEELFEGNL HHHHHHHHHHHCCCC | 50.49 | - | |
47 | Gamma-carboxyglutamic_acid | RAGSYLLEELFEGNL HHHHHHHHHHHCCCC | 50.49 | 2244898 | |
47 | Gamma-carboxyglutamic_acid | RAGSYLLEELFEGNL HHHHHHHHHHHCCCC | 50.49 | 2244898 | |
48 | 4-carboxyglutamate | AGSYLLEELFEGNLE HHHHHHHHHHCCCCC | 59.74 | - | |
48 | Gamma-carboxyglutamic_acid | AGSYLLEELFEGNLE HHHHHHHHHHCCCCC | 59.74 | 2244898 | |
48 | Gamma-carboxyglutamic_acid | AGSYLLEELFEGNLE HHHHHHHHHHCCCCC | 59.74 | 2244898 | |
51 | Gamma-carboxyglutamic_acid | YLLEELFEGNLEKEC HHHHHHHCCCCCHHH | 60.85 | 2244898 | |
51 | 4-carboxyglutamate | YLLEELFEGNLEKEC HHHHHHHCCCCCHHH | 60.85 | - | |
51 | Gamma-carboxyglutamic_acid | YLLEELFEGNLEKEC HHHHHHHCCCCCHHH | 60.85 | 2244898 | |
55 | 4-carboxyglutamate | ELFEGNLEKECYEEI HHHCCCCCHHHHHHH | 51.30 | - | |
55 | Gamma-carboxyglutamic_acid | ELFEGNLEKECYEEI HHHCCCCCHHHHHHH | 51.30 | 2244898 | |
55 | Gamma-carboxyglutamic_acid | ELFEGNLEKECYEEI HHHCCCCCHHHHHHH | 51.30 | 2244898 | |
57 | Gamma-carboxyglutamic_acid | FEGNLEKECYEEICV HCCCCCHHHHHHHHH | 32.72 | 2244898 | |
57 | Gamma-carboxyglutamic_acid | FEGNLEKECYEEICV HCCCCCHHHHHHHHH | 32.72 | 2244898 | |
57 | 4-carboxyglutamate | FEGNLEKECYEEICV HCCCCCHHHHHHHHH | 32.72 | - | |
60 | Gamma-carboxyglutamic_acid | NLEKECYEEICVYEE CCCHHHHHHHHHHHH | 53.17 | 2244898 | |
60 | Gamma-carboxyglutamic_acid | NLEKECYEEICVYEE CCCHHHHHHHHHHHH | 53.17 | 2244898 | |
60 | 4-carboxyglutamate | NLEKECYEEICVYEE CCCHHHHHHHHHHHH | 53.17 | - | |
61 | 4-carboxyglutamate | LEKECYEEICVYEEA CCHHHHHHHHHHHHH | 18.40 | - | |
61 | Gamma-carboxyglutamic_acid | LEKECYEEICVYEEA CCHHHHHHHHHHHHH | 18.40 | 2244898 | |
61 | Gamma-carboxyglutamic_acid | LEKECYEEICVYEEA CCHHHHHHHHHHHHH | 18.40 | 2244898 | |
66 | Gamma-carboxyglutamic_acid | YEEICVYEEAREVFE HHHHHHHHHHHHHHH | 25.45 | 2244898 | |
66 | 4-carboxyglutamate | YEEICVYEEAREVFE HHHHHHHHHHHHHHH | 25.45 | - | |
66 | Gamma-carboxyglutamic_acid | YEEICVYEEAREVFE HHHHHHHHHHHHHHH | 25.45 | 2244898 | |
67 | Gamma-carboxyglutamic_acid | EEICVYEEAREVFEN HHHHHHHHHHHHHHC | 35.03 | 2244898 | |
67 | Gamma-carboxyglutamic_acid | EEICVYEEAREVFEN HHHHHHHHHHHHHHC | 35.03 | 2244898 | |
67 | 4-carboxyglutamate | EEICVYEEAREVFEN HHHHHHHHHHHHHHC | 35.03 | - | |
70 | Gamma-carboxyglutamic_acid | CVYEEAREVFENEVV HHHHHHHHHHHCCCC | 59.62 | 2244898 | |
70 | Gamma-carboxyglutamic_acid | CVYEEAREVFENEVV HHHHHHHHHHHCCCC | 59.62 | 2244898 | |
70 | 4-carboxyglutamate | CVYEEAREVFENEVV HHHHHHHHHHHCCCC | 59.62 | - | |
73 | 4-carboxyglutamate | EEAREVFENEVVTDE HHHHHHHHCCCCCHH | 58.62 | - | |
73 | Gamma-carboxyglutamic_acid | EEAREVFENEVVTDE HHHHHHHHCCCCCHH | 58.62 | 2244898 | |
73 | Gamma-carboxyglutamic_acid | EEAREVFENEVVTDE HHHHHHHHCCCCCHH | 58.62 | 2244898 | |
75 | 4-carboxyglutamate | AREVFENEVVTDEFW HHHHHHCCCCCHHHH | 31.03 | - | |
75 | Gamma-carboxyglutamic_acid | AREVFENEVVTDEFW HHHHHHCCCCCHHHH | 31.03 | 2244898 | |
75 | Gamma-carboxyglutamic_acid | AREVFENEVVTDEFW HHHHHHCCCCCHHHH | 31.03 | 2244898 | |
80 | 4-carboxyglutamate | ENEVVTDEFWRRYKG HCCCCCHHHHHHHCC | 37.43 | - | |
80 | Gamma-carboxyglutamic_acid | ENEVVTDEFWRRYKG HCCCCCHHHHHHHCC | 37.43 | 2244898 | |
80 | Gamma-carboxyglutamic_acid | ENEVVTDEFWRRYKG HCCCCCHHHHHHHCC | 37.43 | 2244898 | |
93 | O-linked_Glycosylation | KGGSPCISQPCLHNG CCCCCCCCCCCCCCC | 34.48 | 2511201 | |
93 | O-linked_Glycosylation | KGGSPCISQPCLHNG CCCCCCCCCCCCCCC | 34.48 | 2511201 | |
99 | N-linked_Glycosylation | ISQPCLHNGSCQDSI CCCCCCCCCCCCCCC | 30.99 | 20427285 | |
104 | Hydroxylation | LHNGSCQDSIWGYTC CCCCCCCCCCCEEEE | 46.55 | - | |
220 | Phosphorylation | VLTTAKCSLLHRNIT EEEECCHHHHCCCEE | 33.00 | - | |
225 | N-linked_Glycosylation | KCSLLHRNITVKTYF CHHHHCCCEEEEEEE | 24.44 | 20427285 | |
233 | N-linked_Glycosylation | ITVKTYFNRTSQDPL EEEEEEECCCCCCCE | 35.59 | 19528533 | |
301 | Phosphorylation | PRTRGLLSGWARNGT HHHCCCHHHHHCCCC | 37.01 | 24043423 | |
306 | N-linked_Glycosylation | LLSGWARNGTDLGNS CHHHHHCCCCCCCCC | 50.39 | UniProtKB CARBOHYD | |
308 | Phosphorylation | SGWARNGTDLGNSLT HHHHCCCCCCCCCCC | 31.44 | 24043423 | |
313 | Phosphorylation | NGTDLGNSLTTRPVT CCCCCCCCCCCCCEE | 25.87 | 24043423 | |
315 | Phosphorylation | TDLGNSLTTRPVTLV CCCCCCCCCCCEEEE | 22.15 | 24043423 | |
316 | Phosphorylation | DLGNSLTTRPVTLVE CCCCCCCCCCEEEEC | 37.96 | 24043423 | |
332 | N-linked_Glycosylation | EECGQVLNVTVTTRT CCCCCEEEEEEECCC | 28.67 | 20427285 | |
344 | Phosphorylation | TRTYCERSSVAAMHW CCCEECCCCCEEEEE | 13.58 | - | |
345 | Phosphorylation | RTYCERSSVAAMHWM CCEECCCCCEEEEEC | 23.23 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PROZ_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PROZ_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PROZ_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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