PROZ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PROZ_HUMAN
• UniProt AC: P22891
• Protein Name: Vitamin K-dependent protein Z
• Gene Name: PROZ
• Organism: Homo sapiens (Human).
• Sequence Length: 400
• Subcellular Localization: Secreted.
• Protein Description: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids..
• Protein Sequence: MAGCVPLLQGLVLVLALHRVEPSVFLPASKANDVLVRWKRAGSYLLEELFEGNLEKECYEEICVYEEAREVFENEVVTDEFWRRYKGGSPCISQPCLHNGSCQDSIWGYTCTCSPGYEGSNCELAKNECHPERTDGCQHFCLPGQESYTCSCAQGYRLGEDHKQCVPHDQCACGVLTSEKRAPDLQDLPWQVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRNITVKTYFNRTSQDPLMIKITHVHVHMRYDADAGENDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSLTTRPVTLVEGEECGQVLNVTVTTRTYCERSSVAAMHWMDGSVVTREHRGSWFLTGVLGSQPVGGQAHMVLVTKVSRYSLWFKQIMN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	4-carboxyglutamate	RAGSYLLEELFEGNL HHHHHHHHHHHCCCC	50.49	-
47	Gamma-carboxyglutamic_acid	RAGSYLLEELFEGNL HHHHHHHHHHHCCCC	50.49	2244898
47	Gamma-carboxyglutamic_acid	RAGSYLLEELFEGNL HHHHHHHHHHHCCCC	50.49	2244898
48	4-carboxyglutamate	AGSYLLEELFEGNLE HHHHHHHHHHCCCCC	59.74	-
48	Gamma-carboxyglutamic_acid	AGSYLLEELFEGNLE HHHHHHHHHHCCCCC	59.74	2244898
48	Gamma-carboxyglutamic_acid	AGSYLLEELFEGNLE HHHHHHHHHHCCCCC	59.74	2244898
51	Gamma-carboxyglutamic_acid	YLLEELFEGNLEKEC HHHHHHHCCCCCHHH	60.85	2244898
51	4-carboxyglutamate	YLLEELFEGNLEKEC HHHHHHHCCCCCHHH	60.85	-
51	Gamma-carboxyglutamic_acid	YLLEELFEGNLEKEC HHHHHHHCCCCCHHH	60.85	2244898
55	4-carboxyglutamate	ELFEGNLEKECYEEI HHHCCCCCHHHHHHH	51.30	-
55	Gamma-carboxyglutamic_acid	ELFEGNLEKECYEEI HHHCCCCCHHHHHHH	51.30	2244898
55	Gamma-carboxyglutamic_acid	ELFEGNLEKECYEEI HHHCCCCCHHHHHHH	51.30	2244898
57	Gamma-carboxyglutamic_acid	FEGNLEKECYEEICV HCCCCCHHHHHHHHH	32.72	2244898
57	Gamma-carboxyglutamic_acid	FEGNLEKECYEEICV HCCCCCHHHHHHHHH	32.72	2244898
57	4-carboxyglutamate	FEGNLEKECYEEICV HCCCCCHHHHHHHHH	32.72	-
60	Gamma-carboxyglutamic_acid	NLEKECYEEICVYEE CCCHHHHHHHHHHHH	53.17	2244898
60	Gamma-carboxyglutamic_acid	NLEKECYEEICVYEE CCCHHHHHHHHHHHH	53.17	2244898
60	4-carboxyglutamate	NLEKECYEEICVYEE CCCHHHHHHHHHHHH	53.17	-
61	4-carboxyglutamate	LEKECYEEICVYEEA CCHHHHHHHHHHHHH	18.40	-
61	Gamma-carboxyglutamic_acid	LEKECYEEICVYEEA CCHHHHHHHHHHHHH	18.40	2244898
61	Gamma-carboxyglutamic_acid	LEKECYEEICVYEEA CCHHHHHHHHHHHHH	18.40	2244898
66	Gamma-carboxyglutamic_acid	YEEICVYEEAREVFE HHHHHHHHHHHHHHH	25.45	2244898
66	4-carboxyglutamate	YEEICVYEEAREVFE HHHHHHHHHHHHHHH	25.45	-
66	Gamma-carboxyglutamic_acid	YEEICVYEEAREVFE HHHHHHHHHHHHHHH	25.45	2244898
67	Gamma-carboxyglutamic_acid	EEICVYEEAREVFEN HHHHHHHHHHHHHHC	35.03	2244898
67	Gamma-carboxyglutamic_acid	EEICVYEEAREVFEN HHHHHHHHHHHHHHC	35.03	2244898
67	4-carboxyglutamate	EEICVYEEAREVFEN HHHHHHHHHHHHHHC	35.03	-
70	Gamma-carboxyglutamic_acid	CVYEEAREVFENEVV HHHHHHHHHHHCCCC	59.62	2244898
70	Gamma-carboxyglutamic_acid	CVYEEAREVFENEVV HHHHHHHHHHHCCCC	59.62	2244898
70	4-carboxyglutamate	CVYEEAREVFENEVV HHHHHHHHHHHCCCC	59.62	-
73	4-carboxyglutamate	EEAREVFENEVVTDE HHHHHHHHCCCCCHH	58.62	-
73	Gamma-carboxyglutamic_acid	EEAREVFENEVVTDE HHHHHHHHCCCCCHH	58.62	2244898
73	Gamma-carboxyglutamic_acid	EEAREVFENEVVTDE HHHHHHHHCCCCCHH	58.62	2244898
75	4-carboxyglutamate	AREVFENEVVTDEFW HHHHHHCCCCCHHHH	31.03	-
75	Gamma-carboxyglutamic_acid	AREVFENEVVTDEFW HHHHHHCCCCCHHHH	31.03	2244898
75	Gamma-carboxyglutamic_acid	AREVFENEVVTDEFW HHHHHHCCCCCHHHH	31.03	2244898
80	4-carboxyglutamate	ENEVVTDEFWRRYKG HCCCCCHHHHHHHCC	37.43	-
80	Gamma-carboxyglutamic_acid	ENEVVTDEFWRRYKG HCCCCCHHHHHHHCC	37.43	2244898
80	Gamma-carboxyglutamic_acid	ENEVVTDEFWRRYKG HCCCCCHHHHHHHCC	37.43	2244898
93	O-linked_Glycosylation	KGGSPCISQPCLHNG CCCCCCCCCCCCCCC	34.48	2511201
93	O-linked_Glycosylation	KGGSPCISQPCLHNG CCCCCCCCCCCCCCC	34.48	2511201
99	N-linked_Glycosylation	ISQPCLHNGSCQDSI CCCCCCCCCCCCCCC	30.99	20427285
104	Hydroxylation	LHNGSCQDSIWGYTC CCCCCCCCCCCEEEE	46.55	-
220	Phosphorylation	VLTTAKCSLLHRNIT EEEECCHHHHCCCEE	33.00	-
225	N-linked_Glycosylation	KCSLLHRNITVKTYF CHHHHCCCEEEEEEE	24.44	20427285
233	N-linked_Glycosylation	ITVKTYFNRTSQDPL EEEEEEECCCCCCCE	35.59	19528533
301	Phosphorylation	PRTRGLLSGWARNGT HHHCCCHHHHHCCCC	37.01	24043423
306	N-linked_Glycosylation	LLSGWARNGTDLGNS CHHHHHCCCCCCCCC	50.39	UniProtKB CARBOHYD
308	Phosphorylation	SGWARNGTDLGNSLT HHHHCCCCCCCCCCC	31.44	24043423
313	Phosphorylation	NGTDLGNSLTTRPVT CCCCCCCCCCCCCEE	25.87	24043423
315	Phosphorylation	TDLGNSLTTRPVTLV CCCCCCCCCCCEEEE	22.15	24043423
316	Phosphorylation	DLGNSLTTRPVTLVE CCCCCCCCCCEEEEC	37.96	24043423
332	N-linked_Glycosylation	EECGQVLNVTVTTRT CCCCCEEEEEEECCC	28.67	20427285
344	Phosphorylation	TRTYCERSSVAAMHW CCCEECCCCCEEEEE	13.58	-
345	Phosphorylation	RTYCERSSVAAMHWM CCEECCCCCEEEEEC	23.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PROZ_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PROZ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PROZ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FOXG1_HUMAN	FOXG1	physical	28514442
INT6_HUMAN	INTS6	physical	28514442
ATP23_HUMAN	XRCC6BP1	physical	28514442
FOXF2_HUMAN	FOXF2	physical	28514442
SI1L2_HUMAN	SIPA1L2	physical	28514442
SDF2L_HUMAN	SDF2L1	physical	28514442
SIK2_HUMAN	SIK2	physical	28514442
MP2K7_HUMAN	MAP2K7	physical	28514442
CDC6_HUMAN	CDC6	physical	28514442
SENP1_HUMAN	SENP1	physical	28514442
RICTR_HUMAN	RICTOR	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
TYW3_HUMAN	TYW3	physical	28514442
MELK_HUMAN	MELK	physical	28514442
EGFL7_HUMAN	EGFL7	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
SELN_HUMAN	SEPN1	physical	28514442
KANK2_HUMAN	KANK2	physical	28514442
GNL3L_HUMAN	GNL3L	physical	28514442
MLF1_HUMAN	MLF1	physical	28514442
ACOT9_HUMAN	ACOT9	physical	28514442
ETV3_HUMAN	ETV3	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
DNJB9_HUMAN	DNAJB9	physical	28514442
HIG1A_HUMAN	HIGD1A	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
N42L2_HUMAN	N4BP2L2	physical	28514442
BCD1_HUMAN	ZNHIT6	physical	28514442
ARVC_HUMAN	ARVCF	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.