PHS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHS_MOUSE
• UniProt AC: P61458
• Protein Name: Pterin-4-alpha-carbinolamine dehydratase
• Gene Name: Pcbd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 104
• Subcellular Localization: Cytoplasm. Nucleus. Cytoplasmic and/or nuclear.
• Protein Description: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity)..
• Protein Sequence: MAGKAHRLSAEERDQLLPNLRAVGWNEVEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGKAHRLS ------CCCCCCCCC	28.35	-
9	Phosphorylation	AGKAHRLSAEERDQL CCCCCCCCHHHHHHH	33.32	29472430
41	Acetylation	IFKQFHFKDFNRAFG HHHHHCCCCHHHHHH	53.49	23954790
41	Ubiquitination	IFKQFHFKDFNRAFG HHHHHCCCCHHHHHH	53.49	-
41	Malonylation	IFKQFHFKDFNRAFG HHHHHCCCCHHHHHH	53.49	26320211
59	Acetylation	RVALQAEKLDHHPEW HHHHHHHHCCCCHHH	63.33	23954790
59	Ubiquitination	RVALQAEKLDHHPEW HHHHHHHHCCCCHHH	63.33	22790023
102	Phosphorylation	FIEQVAVSMT----- HHHHHHHHCC-----	13.63	29472430
104	Phosphorylation	EQVAVSMT------- HHHHHHCC-------	28.14	29472430

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHS_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHS_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHS_MOUSE	Pcbd1	physical	20211142
RPA1_MOUSE	Polr1a	physical	20211142
SRBP1_MOUSE	Srebf1	physical	20211142
HNF1A_MOUSE	Hnf1a	physical	20211142
HNF1B_MOUSE	Hnf1b	physical	20211142
NRIF1_MOUSE	Zfp110	physical	20211142
ASB3_MOUSE	Asb3	physical	20211142
ERCC8_MOUSE	Ercc8	physical	20211142
CERS2_MOUSE	Cers2	physical	20211142
ASB15_MOUSE	Asb15	physical	20211142
CHD4_MOUSE	Chd4	physical	20211142
TLE6_MOUSE	Tle6	physical	20211142
PAWR_MOUSE	Pawr	physical	20211142
ZDH13_MOUSE	Zdhhc13	physical	20211142
HNF1A_MOUSE	Hnf1a	physical	15182178

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.