HNF1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HNF1A_MOUSE
• UniProt AC: P22361
• Protein Name: Hepatocyte nuclear factor 1-alpha
• Gene Name: Hnf1a
• Organism: Mus musculus (Mouse).
• Sequence Length: 628
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'..
• Protein Sequence: MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLMVGEGPLDKGESCGGSRGDLTELPNGLGETRGSEDDTDDDGEDFAPPILKELENLSPEEAAHQKAVVESLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYNGPPPGPGPGPALPAHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGGPLVTVSAALHQVSPTGLEPSSLLSTEAKLVSATGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPHALYSHKPEVAQYTHTSLLPQTMLITDTNLSTLASLTPTKQVFTSDTEASSEPGLHEPPSPATTIHIPSQDPSNIQHLQPAHRLSTSPTVSSSSLVLYQSSDSNGHSHLLPSNHSVIETFISTQMASSSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	GGSRGDLTELPNGLG CCCCCCCCCCCCCCC	39.97	23984901
67	Phosphorylation	LPNGLGETRGSEDDT CCCCCCCCCCCCCCC	38.23	21743459
70	Phosphorylation	GLGETRGSEDDTDDD CCCCCCCCCCCCCCC	34.26	27087446
74	Phosphorylation	TRGSEDDTDDDGEDF CCCCCCCCCCCCCCC	54.36	27087446
93	Phosphorylation	LKELENLSPEEAAHQ HHHHHCCCHHHHHHH	41.68	27818261
210	Phosphorylation	RFKWGPASQQILFQA CCCCCHHHHHHHHHH	26.25	25159016
218	Phosphorylation	QQILFQAYERQKNPS HHHHHHHHHHHCCCC	10.81	25159016
247	Phosphorylation	ECIQRGVSPSQAQGL HHHHCCCCHHHHCCC	22.97	25521595
249	Phosphorylation	IQRGVSPSQAQGLGS HHCCCCHHHHCCCCC	30.55	25521595
303	Phosphorylation	GPALPAHSSPGLPTT CCCCCCCCCCCCCCC	40.09	22817900
304	Phosphorylation	PALPAHSSPGLPTTT CCCCCCCCCCCCCCC	17.08	19060867
309	Phosphorylation	HSSPGLPTTTLSPSK CCCCCCCCCCCCHHH	37.14	23984901
310	Phosphorylation	SSPGLPTTTLSPSKV CCCCCCCCCCCHHHC	24.65	23984901
311	Phosphorylation	SPGLPTTTLSPSKVH CCCCCCCCCCHHHCC	27.93	22817900
313	Phosphorylation	GLPTTTLSPSKVHGV CCCCCCCCHHHCCCE	25.65	22817900
315	Phosphorylation	PTTTLSPSKVHGVRY CCCCCCHHHCCCEEC	43.89	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HNF1A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HNF1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HNF1A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HNF1B_MOUSE	Hnf1b	physical	20211142
TF2AA_MOUSE	Gtf2a1	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis.";
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
J. Proteome Res. 7:3957-3967(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247, AND MASSSPECTROMETRY.
PubMed: 18630941

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-74, AND MASSSPECTROMETRY.
PubMed: 17203969