dbPTM

HNF1B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HNF1B_MOUSE
UniProt AC	P27889
Protein Name	Hepatocyte nuclear factor 1-beta
Gene Name	Hnf1b
Organism	Mus musculus (Mouse).
Sequence Length	558
Subcellular Localization	Nucleus.
Protein Description	Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'..
Protein Sequence	MVSKLTSLQQELLSALLSSGVTKEVLIQALEELLPSPNFGVKLETLPLSPGSGADLDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQNQGPGQSEDTCSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHNLNPLLTHGSPHHQPSSSPPNKMSGVRYNQPGNNEVTSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHSLLSPDSKMQITVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQGVPVINSVASSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSINTLTSMSSSKQCPLQAW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MVSKLTSLQQE ----CCHHHHHHHHH	44.36	-
45	Phosphorylation	NFGVKLETLPLSPGS CCCCEEEECCCCCCC	44.08	23984901
49	Phosphorylation	KLETLPLSPGSGADL EEEECCCCCCCCCCC	25.85	22817900
52	Phosphorylation	TLPLSPGSGADLDTK ECCCCCCCCCCCCCC	33.90	22817900
58	Phosphorylation	GSGADLDTKPVFHTL CCCCCCCCCCCEEEC	44.54	23984901
64	Phosphorylation	DTKPVFHTLTNGHAK CCCCCEEECCCCCCC	24.66	23984901
66	Phosphorylation	KPVFHTLTNGHAKGR CCCEEECCCCCCCCC	40.07	23984901
75	Phosphorylation	GHAKGRLSGDEGSED CCCCCCCCCCCCCCC	42.72	25521595
80	Phosphorylation	RLSGDEGSEDGDDYD CCCCCCCCCCCCCCC	30.39	25521595
279	Phosphorylation	ECLQRGVSPSKAHGL HHHHHCCCHHHHCCC	26.70	22817900
323	Phosphorylation	DAYSSNQTHNLNPLL HHHCCCCCCCCCHHC	19.58	21183079
331	Phosphorylation	HNLNPLLTHGSPHHQ CCCCHHCCCCCCCCC	31.69	17242355
334	Phosphorylation	NPLLTHGSPHHQPSS CHHCCCCCCCCCCCC	17.29	22817900
340	Phosphorylation	GSPHHQPSSSPPNKM CCCCCCCCCCCCCCC	36.56	19060867
341	Phosphorylation	SPHHQPSSSPPNKMS CCCCCCCCCCCCCCC	54.25	27087446
342	Phosphorylation	PHHQPSSSPPNKMSG CCCCCCCCCCCCCCC	49.03	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HNF1B_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HNF1B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HNF1B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
KAT2B_MOUSE	Kat2b	physical	15509593
HDAC1_MOUSE	Hdac1	physical	15509593

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HNF1B_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND SER-80, AND MASSSPECTROMETRY.	17242355 [Abstract]