dbPTM

ASB3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ASB3_MOUSE
UniProt AC	Q9WV72
Protein Name	Ankyrin repeat and SOCS box protein 3
Gene Name	Asb3
Organism	Mus musculus (Mouse).
Sequence Length	525
Subcellular Localization
Protein Description	Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B (By similarity)..
Protein Sequence	MDFTEAYSDTCSTVGLAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYIKAKTFEGFCALHLAVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNGSHSMSGWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNGYSPDAQMCLVFGFSSPLCMAFQKDCDFSGIVNILLKYGAQLNELHLAYCLKYEKFSMFCSFLKKGSLMVPWNHTSEFISYAVKAQTKYKAWLPHLLLAGFDPLILLCSSSWVDSASDDILIFTLEFSNWKRLPSAVEKMLSVRANSSWALQQHLASVPSLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEEVLRMNEILEPAANQDGETSKAT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
35	Phosphorylation	KLLKKGRSVDVADNR HHHHCCCCCCCCCCC	31.19	25521595
189	Phosphorylation	PLFVAAQYGKLESMS HHHHHHHHCCCCCCE	16.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ASB3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ASB3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ASB3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SSBP3_MOUSE	Ssbp3	physical	20211142

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ASB3_MOUSE

Related Literatures of Post-Translational Modification