MAD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAD3_HUMAN
• UniProt AC: Q9BW11
• Protein Name: Max dimerization protein 3
• Gene Name: MXD3
• Organism: Homo sapiens (Human).
• Sequence Length: 206
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity)..
• Protein Sequence: MEPLASNIQVLLQAAEFLERREREAEHGYASLCPHRSPGPIHRRKKRPPQAPGAQDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARMHIQKLEDQEQRARQLKERLRSKQQSLQRQLEQLRGLAGAAERERLRADSLDSSGLSSERSDSDQEELEVDVESLVFGGEAELLRGFVAGQEHSYSHGGGAWL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	EAEHGYASLCPHRSP HHHHCCHHHCCCCCC	23.24	28348404
37	Phosphorylation	ASLCPHRSPGPIHRR HHHCCCCCCCCCCCC	31.04	28348404
46	Ubiquitination	GPIHRRKKRPPQAPG CCCCCCCCCCCCCCC	69.22	-
46	Ubiquitination	GPIHRRKKRPPQAPG CCCCCCCCCCCCCCC	69.22	-
67	Ubiquitination	SVHNELEKRRRAQLK HHHHHHHHHHHHHHH	64.92	-
67	Ubiquitination	SVHNELEKRRRAQLK HHHHHHHHHHHHHHH	64.92	-
81	Ubiquitination	KRCLERLKQQMPLGA HHHHHHHHHHCCCCC	44.71	-
81	Ubiquitination	KRCLERLKQQMPLGA HHHHHHHHHHCCCCC	44.71	-
99 (in isoform 2)	Ubiquitination	-	2.90	21906983
108	Ubiquitination	RARMHIQKLEDQEQR HHHHHHHHHHHHHHH	53.92	2190698
108	Ubiquitination	RARMHIQKLEDQEQR HHHHHHHHHHHHHHH	53.92	21906983
108 (in isoform 1)	Ubiquitination	-	53.92	21906983
108 (in isoform 3)	Ubiquitination	-	53.92	21906983
164	Phosphorylation	SGLSSERSDSDQEEL CCCCCCCCCCCHHHH	37.10	27732954
166	Phosphorylation	LSSERSDSDQEELEV CCCCCCCCCHHHHHH	42.30	27732954
177	Phosphorylation	ELEVDVESLVFGGEA HHHHHHHHHHCCCCH	29.67	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAX_HUMAN	MAX	physical	10593926
NFKB1_HUMAN	NFKB1	physical	7694229
KR107_HUMAN	KRTAP10-7	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
MNT_HUMAN	MNT	physical	28514442
SIN3A_HUMAN	SIN3A	physical	28514442
SP30L_HUMAN	SAP30L	physical	28514442
SDS3_HUMAN	SUDS3	physical	28514442
ARI4B_HUMAN	ARID4B	physical	28514442
SP130_HUMAN	SAP130	physical	28514442
ING2_HUMAN	ING2	physical	28514442
BRM1L_HUMAN	BRMS1L	physical	28514442
TSYL2_HUMAN	TSPYL2	physical	28514442
N62CL_HUMAN	NUP62CL	physical	28514442
TFP11_HUMAN	TFIP11	physical	28514442
KI20B_HUMAN	KIF20B	physical	28514442
SAP30_HUMAN	SAP30	physical	28514442
BRMS1_HUMAN	BRMS1	physical	28514442
ZMYM3_HUMAN	ZMYM3	physical	28514442
MXI1_HUMAN	MXI1	physical	28514442
EDEM2_HUMAN	EDEM2	physical	28514442
ASPM_HUMAN	ASPM	physical	28514442
RCOR3_HUMAN	RCOR3	physical	28514442
CENPB_HUMAN	CENPB	physical	28514442
MAX_HUMAN	MAX	physical	28514442
TXD11_HUMAN	TXNDC11	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.