KI3L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KI3L2_HUMAN
• UniProt AC: P43630
• Protein Name: Killer cell immunoglobulin-like receptor 3DL2
• Gene Name: KIR3DL2
• Organism: Homo sapiens (Human).
• Sequence Length: 455
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis..
• Protein Sequence: MSLTVVSMACVGFFLLQGAWPLMGGQDKPFLSARPSTVVPRGGHVALQCHYRRGFNNFMLYKEDRSHVPIFHGRIFQESFIMGPVTPAHAGTYRCRGSRPHSLTGWSAPSNPLVIMVTGNHRKPSLLAHPGPLLKSGETVILQCWSDVMFEHFFLHREGISEDPSRLVGQIHDGVSKANFSIGPLMPVLAGTYRCYGSVPHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVQAGENVTLSCSSWSSYDIYHLSREGEAHERRLRAVPKVNRTFQADFPLGPATHGGTYRCFGSFRALPCVWSNSSDPLLVSVTGNPSSSWPSPTEPSSKSGICRHLHVLIGTSVVIFLFILLLFFLLYRWCSNKKNAAVMDQEPAGDRTVNRQDSDEQDPQEVTYAQLDHCVFIQRKISRPSQRPKTPLTDTSVYTELPNAEPRSKVVSCPRAPQSGLEGVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLTVVSMA ------CCCCHHHHH	32.52	26074081
4	Phosphorylation	----MSLTVVSMACV ----CCCCHHHHHHH	16.14	26074081
7	Phosphorylation	-MSLTVVSMACVGFF -CCCCHHHHHHHHHH	9.05	26074081
66	Phosphorylation	MLYKEDRSHVPIFHG EEEECCCCCCCCEEC	40.95	24719451
79	Phosphorylation	HGRIFQESFIMGPVT ECEECCEEEEECCCC	14.86	24719451
93	Phosphorylation	TPAHAGTYRCRGSRP CCCCCCEEECCCCCC	13.54	28258704
179	N-linked_Glycosylation	HDGVSKANFSIGPLM CCCCCCCCCCCCCCH	34.63	UniProtKB CARBOHYD
221	Phosphorylation	DIVITGLYEKPSLSA CEEEEECCCCCCCCC	24.21	18083107
239	N-linked_Glycosylation	PTVQAGENVTLSCSS CEEECCCCEEEEEEC	31.02	UniProtKB CARBOHYD
253	Phosphorylation	SWSSYDIYHLSREGE CCCCEEEEECCCCCH	8.20	-
256	Phosphorylation	SYDIYHLSREGEAHE CEEEEECCCCCHHHH	18.25	-
271	Ubiquitination	RRLRAVPKVNRTFQA HHHHHCCCCCCEEEC	45.61	-
273	N-linked_Glycosylation	LRAVPKVNRTFQADF HHHCCCCCCEEECCC	43.32	UniProtKB CARBOHYD
306	N-linked_Glycosylation	ALPCVWSNSSDPLLV EEEEEECCCCCCEEE	29.80	UniProtKB CARBOHYD
397	O-linked_Glycosylation	EQDPQEVTYAQLDHC CCCHHHCHHHHHCEE	16.64	OGP
398	Phosphorylation	QDPQEVTYAQLDHCV CCHHHCHHHHHCEEE	9.49	-
428	Phosphorylation	PLTDTSVYTELPNAE CCCCCCCEECCCCCC	8.35	-
429	O-linked_Glycosylation	LTDTSVYTELPNAEP CCCCCCEECCCCCCC	28.96	OGP
449	Phosphorylation	SCPRAPQSGLEGVF- ECCCCCCCCCCCCC-	44.26	30257219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KI3L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KI3L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KI3L2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1A02_HUMAN	HLA-A	physical	8617928
1A03_HUMAN	HLA-A	physical	8617928
1A01_HUMAN	HLA-A	physical	8617928
1A26_HUMAN	HLA-A	physical	8617928
F1142_HUMAN	FAM114A2	physical	28514442
PDLI4_HUMAN	PDLIM4	physical	28514442
FBX38_HUMAN	FBXO38	physical	28514442
F172A_HUMAN	FAM172A	physical	28514442
TM214_HUMAN	TMEM214	physical	28514442
IVD_HUMAN	IVD	physical	28514442
GLMN_HUMAN	GLMN	physical	28514442
ATRIP_HUMAN	ATRIP	physical	28514442
AVR2B_HUMAN	ACVR2B	physical	28514442
CISD2_HUMAN	CISD2	physical	28514442
S27A3_HUMAN	SLC27A3	physical	28514442
LRP12_HUMAN	LRP12	physical	28514442
MET15_HUMAN	METTL15	physical	28514442
ST7L_HUMAN	ST7L	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
BACD3_HUMAN	KCTD10	physical	28514442
TRI13_HUMAN	TRIM13	physical	28514442
UFSP2_HUMAN	UFSP2	physical	28514442
T132A_HUMAN	TMEM132A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.