BFSP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BFSP2_HUMAN
• UniProt AC: Q13515
• Protein Name: Phakinin
• Gene Name: BFSP2
• Organism: Homo sapiens (Human).
• Sequence Length: 415
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Detected adjacent to the cell membrane.
• Protein Description: Involved in stabilization of lens fiber cell cytoskeleton..
• Protein Sequence: MSERRVVVDLPTSASSSMPLQRRRASFRGPRSSSSLESPPASRTNAMSGLVRAPGVYVGTAPSGCIGGLGARVTRRALGISSVFLQGLRSSGLATVPAPGLERDHGAVEDLGGCLVEYMAKVHALEQVSQELETQLRMHLESKATRSGNWGALRASWASSCQQVGEAVLENARLMLQTETIQAGADDFKERYENEQPFRKAAEEEINSLYKVIDEANLTKMDLESQIESLKEELGSLSRNYEEDVKLLHKQLAGCELEQMDAPIGTGLDDILETIRIQWERDVEKNRVEAGALLQAKQQAEVAHMSQTQEEKLAAALRVELHNTSCQVQSLQAETESLRALKRGLENTLHDAKHWHDMELQNLGAVVGRLEAELREIRAEAEQQQQERAHLLARKCQLQKDVASYHALLDREESG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSERRVVVD ------CCCCEEEEE	39.55	-
26	Phosphorylation	PLQRRRASFRGPRSS CCHHHHHHHCCCCCC	17.42	-
32	Phosphorylation	ASFRGPRSSSSLESP HHHCCCCCCCCCCCC	37.39	-
35	Phosphorylation	RGPRSSSSLESPPAS CCCCCCCCCCCCCCC	37.80	-
57	Phosphorylation	LVRAPGVYVGTAPSG CCCCCCEEEECCCCC	10.08	23403867
60	Phosphorylation	APGVYVGTAPSGCIG CCCEEEECCCCCCCC	25.92	23403867
63	Phosphorylation	VYVGTAPSGCIGGLG EEEECCCCCCCCHHH	43.78	22210691
82	Phosphorylation	RRALGISSVFLQGLR HHHHCCCHHHHHHHH	18.24	18785766
90	Phosphorylation	VFLQGLRSSGLATVP HHHHHHHHCCCCCCC	33.53	-
210	Phosphorylation	EEEINSLYKVIDEAN HHHHHHHHHHHHHHC	11.75	-
225	Phosphorylation	LTKMDLESQIESLKE CCCCCHHHHHHHHHH	43.70	22210691
229	Phosphorylation	DLESQIESLKEELGS CHHHHHHHHHHHHHH	46.50	22210691
231	Acetylation	ESQIESLKEELGSLS HHHHHHHHHHHHHHC	59.42	7970947
238	Phosphorylation	KEELGSLSRNYEEDV HHHHHHHCCCHHHHH	21.85	22210691
404	Phosphorylation	QLQKDVASYHALLDR HHHHHHHHHHHHHHH	19.80	25627689
414	Phosphorylation	ALLDREESG------ HHHHHHHCC------	45.08	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BFSP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BFSP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BFSP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MBIP1_HUMAN	MBIP	physical	25416956
SYCE1_HUMAN	SYCE1	physical	25416956
BFSP1_HUMAN	BFSP1	physical	28514442
TRIPB_HUMAN	TRIP11	physical	28514442
NEK2_HUMAN	NEK2	physical	28514442
CDR2L_HUMAN	CDR2L	physical	28514442
CENPE_HUMAN	CENPE	physical	28514442
SUFU_HUMAN	SUFU	physical	28514442
CACO1_HUMAN	CALCOCO1	physical	28514442
MAX_HUMAN	MAX	physical	28514442
TRI11_HUMAN	TRIM11	physical	28514442
CEP44_HUMAN	CEP44	physical	28514442
SCOC_HUMAN	SCOC	physical	28514442
SPAG5_HUMAN	SPAG5	physical	28514442
BANP_HUMAN	BANP	physical	28514442
AINX_HUMAN	INA	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H01202: Cataract
• OMIM Disease
• 611597: Cataract 12, multiple types (CTRCT12)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.