CDR2L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDR2L_HUMAN
• UniProt AC: Q86X02
• Protein Name: Cerebellar degeneration-related protein 2-like
• Gene Name: CDR2L
• Organism: Homo sapiens (Human).
• Sequence Length: 465
• Protein Sequence: MRRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHSSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	AEEEESWYDQQDLEQ HHHHHCCCCHHHHHH	17.10	27642862
84	Phosphorylation	NEQHAKVYEQLDLTA HHHHHHHHHHHCCCH	9.39	27642862
106	Ubiquitination	HRLVLESKAAQQKIH CHHHHCHHHHHHHHH	38.06	-
154	Phosphorylation	EKRERRRTIHTFPCL HHHHHHHCCCHHHHH	18.46	27273156
157	Phosphorylation	ERRRTIHTFPCLKEL HHHHCCCHHHHHHHH	25.97	30266825
166	Phosphorylation	PCLKELCTSPRCKDA HHHHHHCCCCCCCHH	55.16	27794612
167	Phosphorylation	CLKELCTSPRCKDAF HHHHHCCCCCCCHHH	14.89	21815630
178	Phosphorylation	KDAFRLHSSSLELGP CHHHHHCCCCCCCCC	26.64	30266825
179	Phosphorylation	DAFRLHSSSLELGPR HHHHHCCCCCCCCCC	28.35	23401153
180	Phosphorylation	AFRLHSSSLELGPRP HHHHCCCCCCCCCCC	28.95	30266825
303	Phosphorylation	LGAQDGVSSPAASPG CCCCCCCCCCCCCCC	35.81	30266825
304	Phosphorylation	GAQDGVSSPAASPGH CCCCCCCCCCCCCCC	19.02	30266825
308	Phosphorylation	GVSSPAASPGHVVRK CCCCCCCCCCCEEEC	33.26	30266825
316	Phosphorylation	PGHVVRKSCSDTALN CCCEEECCCCHHHHH	14.32	25159151
318	Phosphorylation	HVVRKSCSDTALNAI CEEECCCCHHHHHHH	45.12	25159151
320	Phosphorylation	VRKSCSDTALNAIVA EECCCCHHHHHHHHC	19.42	29978859
339	Phosphorylation	SRHAGNLTLHANSVR HCCCCCEEEEHHHHH	22.09	24117733
344	Phosphorylation	NLTLHANSVRKRGMS CEEEEHHHHHHHCHH	24.88	25159151
351	Phosphorylation	SVRKRGMSILREVDE HHHHHCHHHHHHHHH	22.69	23090842
388	Phosphorylation	VRHAGVQTSRPISRD CCCCCCCCCCCCCCC	25.05	23403867
389	Phosphorylation	RHAGVQTSRPISRDS CCCCCCCCCCCCCCC	20.97	23403867
393	Phosphorylation	VQTSRPISRDSSWRD CCCCCCCCCCCCCCC	32.49	27794612
396	Phosphorylation	SRPISRDSSWRDLRG CCCCCCCCCCCCCCC	30.59	22964224
397	Phosphorylation	RPISRDSSWRDLRGG CCCCCCCCCCCCCCC	30.35	22964224
417	Phosphorylation	EVKAGEKSLSQHVEA CCCCCCCCHHHHHHH	29.02	25159151
419	Phosphorylation	KAGEKSLSQHVEAVD CCCCCCHHHHHHHHH	25.90	29214152
458	Acetylation	KADINATKVKTHSSK HCHHHCCCCCCCCCC	39.05	7265689

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDR2L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDR2L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDR2L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDR2_HUMAN	CDR2	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-179; SER-304AND SER-308, AND MASS SPECTROMETRY.
PubMed: 18220336