5HT6R_HUMAN - dbPTM
5HT6R_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID 5HT6R_HUMAN
UniProt AC P50406
Protein Name 5-hydroxytryptamine receptor 6
Gene Name HTR6
Organism Homo sapiens (Human).
Sequence Length 440
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling. [PubMed: 23027611]
Protein Sequence MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
103PhosphorylationRGLCLLWTAFDVMCC
HHHHHHHHHHHHHHH		19.8824043423
111PhosphorylationAFDVMCCSASILNLC
HHHHHHHCHHHHHHH		21.8124043423
113PhosphorylationDVMCCSASILNLCLI
HHHHHCHHHHHHHHH		16.0024043423
121PhosphorylationILNLCLISLDRYLLI
HHHHHHHHHHHHHHH		15.9824043423
125PhosphorylationCLISLDRYLLILSPL
HHHHHHHHHHHHCHH		12.9116094384
130PhosphorylationDRYLLILSPLRYKLR
HHHHHHHCHHHHHHC		18.2024719451
227PhosphorylationVQVASLTTGMASQAS
HHHHHHHHCCCCHHH		30.1930257219
234PhosphorylationTGMASQASETLQVPR
HCCCCHHHCCCCCCC		24.3927732954
236PhosphorylationMASQASETLQVPRTP
CCCHHHCCCCCCCCC		21.7227732954
258"N6,N6-dimethyllysine"DSRRLATKHSRKALK
HHHHHCHHHHHHHHH		33.69-
258MethylationDSRRLATKHSRKALK
HHHHHCHHHHHHHHH		33.69-
262"N6,N6-dimethyllysine"LATKHSRKALKASLT
HCHHHHHHHHHHHHH		62.17-
262MethylationLATKHSRKALKASLT
HCHHHHHHHHHHHHH		62.17-
347PhosphorylationCPRERQASLASPSLR
CCHHHHHHHCCCCCC		19.01108417601
350PhosphorylationERQASLASPSLRTSH
HHHHHHCCCCCCCCC		21.9524043423
352PhosphorylationQASLASPSLRTSHSG
HHHHCCCCCCCCCCC		28.1724043423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
350SPhosphorylationKinaseCDK5Q00535
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of 5HT6R_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of 5HT6R_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CSN5_HUMANCOPS5physical
20093369
ATM_HUMANATMphysical
23027611
ATR_HUMANATRphysical
23027611
ATX10_HUMANATXN10physical
23027611
CAND2_HUMANCAND2physical
23027611
CDK5_HUMANCDK5physical
23027611
CLH1_HUMANCLTCphysical
23027611
CND3_HUMANNCAPGphysical
23027611
COG3_HUMANCOG3physical
23027611
COPG2_HUMANCOPG2physical
23027611
DYN2_HUMANDNM2physical
23027611
EXOC2_HUMANEXOC2physical
23027611
IPO8_HUMANIPO8physical
23027611
TTI1_HUMANTTI1physical
23027611
MTOR_HUMANMTORphysical
23027611
NCDN_HUMANNCDNphysical
23027611
NF1_HUMANNF1physical
23027611
NSF_HUMANNSFphysical
23027611
RNBP6_HUMANRANBP6physical
23027611
RPTOR_HUMANRPTORphysical
23027611
SMG1_HUMANSMG1physical
23027611
TBCD_HUMANTBCDphysical
23027611
TELO2_HUMANTELO2physical
23027611
TNPO1_HUMANTNPO1physical
23027611
XPO4_HUMANXPO4physical
23027611
XPOT_HUMANXPOTphysical
23027611
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00458 Quetiapine fumarate (JP16/USAN); Seroquel (TN)
D07218 Metergoline (INN)
D08456 Quetiapine (INN); Norsic (TN)
D09918 Latrepirdine dihydrochloride (USAN); Dimebolin; Dimebon
D10099 Cerlapirdine (USAN)
D10100 Cerlapirdine hydrochloride (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of 5HT6R_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry.";
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.;
Nat. Methods 2:591-598(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-125, AND MASSSPECTROMETRY.

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