ZN550_HUMAN - dbPTM
ZN550_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN550_HUMAN
UniProt AC Q7Z398
Protein Name Zinc finger protein 550
Gene Name ZNF550
Organism Homo sapiens (Human).
Sequence Length 422
Subcellular Localization Nucleus .
Protein Description May be involved in transcriptional regulation..
Protein Sequence MAETKDAAQMLVTFKDVAVTFTREEWRQLDLAQRTLYREVMLETCGLLVSLGHRVPKPELVHLLEHGQELWIVKRGLSHATCAGDRAQVHTREPTTYPPVLSERAFLRGSLTLESSTSSDSRLGRARDEEGLLEMQKGKVTPETDLHKETHLGKVSLEGEGLGTDDGLHSRALQEWLSADVLHECDSQQPGKDALIHAGTNPYKCKQCGKGFNRKWYLVRHQRVHTGMKPYECNACGKAFSQSSTLIRHYLIHTGEKPYKCLECGKAFKRRSYLMQHHPIHTGEKPYECSQCRKAFTHRSTFIRHNRTHTGEKPFECKECEKAFSNRAHLIQHYIIHTGEKPYDCMACGKAFRCSSELIQHQRIHTGEKPYECTQCGKAFHRSTYLIQHSVIHTGEMPYKCIECGKAFKRRSHLLQHQRVHT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAETKDAAQML
----CCCCHHHHHHH		25.3729759185
13PhosphorylationDAAQMLVTFKDVAVT
HHHHHHHHHHHHEEE		22.4729759185
20PhosphorylationTFKDVAVTFTREEWR
HHHHHEEEECHHHHH		15.0029759185
22PhosphorylationKDVAVTFTREEWRQL
HHHEEEECHHHHHHH		28.0129759185
37 (in isoform 2)Phosphorylation-12.2422210691
63 (in isoform 2)Phosphorylation-4.7122210691
78PhosphorylationWIVKRGLSHATCAGD
EEEECCCCCCCCCCC		17.5628555341
95PhosphorylationQVHTREPTTYPPVLS
EEECCCCCCCCCCCC		33.92-
96PhosphorylationVHTREPTTYPPVLSE
EECCCCCCCCCCCCC		44.75-
97PhosphorylationHTREPTTYPPVLSER
ECCCCCCCCCCCCCC		14.17-
102PhosphorylationTTYPPVLSERAFLRG
CCCCCCCCCCHHHCC		25.85-
137UbiquitinationEGLLEMQKGKVTPET
HHHHHHHCCCCCCCC		60.43-
141PhosphorylationEMQKGKVTPETDLHK
HHHCCCCCCCCCCCC		20.9229214152
148UbiquitinationTPETDLHKETHLGKV
CCCCCCCCCCCCEEE		72.1629967540
154UbiquitinationHKETHLGKVSLEGEG
CCCCCCEEEEECCCC		34.7029967540
156PhosphorylationETHLGKVSLEGEGLG
CCCCEEEEECCCCCC		24.9628555341
192UbiquitinationCDSQQPGKDALIHAG
CCCCCCCCCCEEECC		46.6529967540
215UbiquitinationCGKGFNRKWYLVRHQ
CCCCCCCEEEEEEEE		41.09-
241PhosphorylationNACGKAFSQSSTLIR
CCCCCCCCCCHHHHH		33.7322210691
243PhosphorylationCGKAFSQSSTLIRHY
CCCCCCCCHHHHHHH		24.8822210691
244PhosphorylationGKAFSQSSTLIRHYL
CCCCCCCHHHHHHHH		21.4222210691
248UbiquitinationSQSSTLIRHYLIHTG
CCCHHHHHHHHHCCC		18.6022505724
250PhosphorylationSSTLIRHYLIHTGEK
CHHHHHHHHHCCCCC		9.4822210691
254PhosphorylationIRHYLIHTGEKPYKC
HHHHHHCCCCCCEEE		39.7929496963
257UbiquitinationYLIHTGEKPYKCLEC
HHHCCCCCCEEEHHH		55.8022505724
259PhosphorylationIHTGEKPYKCLECGK
HCCCCCCEEEHHHCH		25.9615592455
260SumoylationHTGEKPYKCLECGKA
CCCCCCEEEHHHCHH		40.65-
260SumoylationHTGEKPYKCLECGKA
CCCCCCEEEHHHCHH		40.65-
266UbiquitinationYKCLECGKAFKRRSY
EEEHHHCHHHHHHHH		63.41-
272PhosphorylationGKAFKRRSYLMQHHP
CHHHHHHHHHHHCCC		27.01-
273PhosphorylationKAFKRRSYLMQHHPI
HHHHHHHHHHHCCCC		12.37-
282PhosphorylationMQHHPIHTGEKPYEC
HHCCCCCCCCCCCCC		47.99-
287PhosphorylationIHTGEKPYECSQCRK
CCCCCCCCCCHHHHH		40.4126699800
290PhosphorylationGEKPYECSQCRKAFT
CCCCCCCHHHHHHHH		22.0026699800
297PhosphorylationSQCRKAFTHRSTFIR
HHHHHHHHCCCHHCC		22.6526699800
308PhosphorylationTFIRHNRTHTGEKPF
HHCCCCCCCCCCCCC		29.16-
310PhosphorylationIRHNRTHTGEKPFEC
CCCCCCCCCCCCCCC		46.5621857030
313UbiquitinationNRTHTGEKPFECKEC
CCCCCCCCCCCCHHH		57.25-
338PhosphorylationIQHYIIHTGEKPYDC
HHHHHEECCCCCCCC		36.3127251275
356PhosphorylationGKAFRCSSELIQHQR
CCCEECCHHHHHCCC		39.7928348404
366PhosphorylationIQHQRIHTGEKPYEC
HHCCCCCCCCCCCEE		44.6728111955
394PhosphorylationIQHSVIHTGEMPYKC
EECCEEECCCCCCEE		24.58-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN550_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN550_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN550_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MEIOC_HUMANC17orf104physical
28514442
ZN714_HUMANZNF714physical
28514442
YTDC2_HUMANYTHDC2physical
28514442
TRI37_HUMANTRIM37physical
28514442
ZN460_HUMANZNF460physical
28514442
ZNF92_HUMANZNF92physical
28514442
RBAK_HUMANRBAKphysical
28514442
UBP34_HUMANUSP34physical
28514442
TRI41_HUMANTRIM41physical
28514442
FBLN5_HUMANFBLN5physical
28514442
PP2AA_HUMANPPP2CAphysical
28514442
STRN4_HUMANSTRN4physical
28514442
2AAB_HUMANPPP2R1Bphysical
28514442
STRN3_HUMANSTRN3physical
28514442
SMRCD_HUMANSMARCAD1physical
28514442
CENPB_HUMANCENPBphysical
28514442
CT2NL_HUMANCTTNBP2NLphysical
28514442
SLMAP_HUMANSLMAPphysical
28514442
MDM2_HUMANMDM2physical
28514442
STRP1_HUMANSTRIP1physical
28514442
STRN_HUMANSTRNphysical
28514442
SIR1_HUMANSIRT1physical
28514442
2ABD_HUMANPPP2R2Dphysical
28514442
TIF1A_HUMANTRIM24physical
28514442
PASK_HUMANPASKphysical
28514442
ERBIN_HUMANERBB2IPphysical
28514442
LRRC1_HUMANLRRC1physical
28514442
CR025_HUMANC18orf25physical
28514442
LTBP4_HUMANLTBP4physical
28514442
2AAA_HUMANPPP2R1Aphysical
28514442
RT09_HUMANMRPS9physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN550_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-259, AND MASSSPECTROMETRY.

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