UBP45_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP45_HUMAN
• UniProt AC: Q70EL2
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 45
• Gene Name: USP45
• Organism: Homo sapiens (Human).
• Sequence Length: 814
• Protein Sequence: MRVKDPTKALPEKAKRSKRPTVPHDEDSSDDIAVGLTCQHVSHAISVNHVKRAIAENLWSVCSECLKERRFYDGQLVLTSDIWLCLKCGFQGCGKNSESQHSLKHFKSSRTEPHCIIINLSTWIIWCYECDEKLSTHCNKKVLAQIVDFLQKHASKTQTSAFSRIMKLCEEKCETDEIQKGGKCRNLSVRGITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKIFPSSDSQLDPLVVELSRPGPLTSALFLFLHSMKETEKGPLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADDETRKKVKAYGKEGVKMNFIDRIFIGELTSTVMCEECANISTVKDPFIDISLPIIEERVSKPLLWGRMNKYRSLRETDHDRYSGNVTIENIHQPRAAKKHSSSKDKSQLIHDRKCIRKLSSGETVTYQKNENLEMNGDSLMFASLMNSESRLNESPTDDSEKEASHSESNVDADSEPSESESASKQTGLFRSSSGSGVQPDGPLYPLSAGKLLYTKETDSGDKEMAEAISELRLSSTVTGDQDFDRENQPLNISNNLCFLEGKHLRSYSPQNAFQTLSQSYITTSKECSIQSCLYQFTSMELLMGNNKLLCENCTKNKQKYQEETSFAEKKVEGVYTNARKQLLISAVPAVLILHLKRFHQAGLSLRKVNRHVDFPLMLDLAPFCSATCKNASVGDKVLYGLYGIVEHSGSMREGHYTAYVKVRTPSRKLSEHNTKKKNVPGLKAADNESAGQWVHVSDTYLQVVPESRALSAQAYLLFYERVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	TVPHDEDSSDDIAVG CCCCCCCCCCCEEHH	33.35	29449344
29	Phosphorylation	VPHDEDSSDDIAVGL CCCCCCCCCCEEHHH	52.18	29449344
71 (in isoform 3)	Ubiquitination	-	9.03	21890473
141	Ubiquitination	LSTHCNKKVLAQIVD HHHHCCHHHHHHHHH	28.61	-
156	Ubiquitination	FLQKHASKTQTSAFS HHHHHCCHHHHHHHH	45.49	-
252	Phosphorylation	LSRPGPLTSALFLFL CCCCCCHHHHHHHHH	18.32	26074081
253	Phosphorylation	SRPGPLTSALFLFLH CCCCCHHHHHHHHHH	30.56	26074081
261	Phosphorylation	ALFLFLHSMKETEKG HHHHHHHHCHHCCCC	33.43	26074081
271	Phosphorylation	ETEKGPLSPKVLFNQ HCCCCCCCHHHHHHH	26.30	24719451
316	Phosphorylation	ETKRIQASILKAFNN HHHHHHHHHHHHHCC	16.45	24719451
325	Phosphorylation	LKAFNNPTTKTADDE HHHHCCCCCCCCCHH	42.94	26546556
390	Phosphorylation	PIIEERVSKPLLWGR HHHHHHCCCCCHHHC	34.47	24719451
391 (in isoform 1)	Ubiquitination	-	36.51	21890473
391	Ubiquitination	IIEERVSKPLLWGRM HHHHHCCCCCHHHCH	36.51	21890473
403	Phosphorylation	GRMNKYRSLRETDHD HCHHHCCCHHHCCCC	28.78	-
432	Phosphorylation	RAAKKHSSSKDKSQL CCCCCCCCCCCHHHH	40.92	-
450	Phosphorylation	RKCIRKLSSGETVTY HHHHHHHCCCCEEEE	39.05	25159151
451	Phosphorylation	KCIRKLSSGETVTYQ HHHHHHCCCCEEEEE	51.60	25159151
454	Phosphorylation	RKLSSGETVTYQKNE HHHCCCCEEEEECCC	22.98	23403867
456	Phosphorylation	LSSGETVTYQKNENL HCCCCEEEEECCCCC	27.88	23403867
457	Phosphorylation	SSGETVTYQKNENLE CCCCEEEEECCCCCE	17.10	27642862
474	Phosphorylation	GDSLMFASLMNSESR CCHHHHHHHHCCHHH	19.52	-
485	Phosphorylation	SESRLNESPTDDSEK CHHHCCCCCCCHHHH	31.84	28985074
490	Phosphorylation	NESPTDDSEKEASHS CCCCCCHHHHHHHHC	54.07	-
508	Phosphorylation	VDADSEPSESESASK CCCCCCCCCCHHHHH	50.10	-
522	Phosphorylation	KQTGLFRSSSGSGVQ HHCCCCCCCCCCCCC	22.86	25262027
523	Phosphorylation	QTGLFRSSSGSGVQP HCCCCCCCCCCCCCC	34.17	25627689
524	Phosphorylation	TGLFRSSSGSGVQPD CCCCCCCCCCCCCCC	37.92	25627689
526	Phosphorylation	LFRSSSGSGVQPDGP CCCCCCCCCCCCCCC	37.43	25627689
560	Phosphorylation	KEMAEAISELRLSST HHHHHHHHHHHHCCC	37.31	24719451
597	Phosphorylation	LEGKHLRSYSPQNAF ECCCCHHHCCCCHHH	36.00	27732954
598	Phosphorylation	EGKHLRSYSPQNAFQ CCCCHHHCCCCHHHH	20.24	28555341
599	Phosphorylation	GKHLRSYSPQNAFQT CCCHHHCCCCHHHHH	22.66	25159151
606	Phosphorylation	SPQNAFQTLSQSYIT CCCHHHHHHHHHHCC	23.17	27732954
651	Phosphorylation	CTKNKQKYQEETSFA CCCCHHHHHHHCCHH	20.75	29978859
655	Phosphorylation	KQKYQEETSFAEKKV HHHHHHHCCHHHHHH	28.52	29978859
656	Phosphorylation	QKYQEETSFAEKKVE HHHHHHCCHHHHHHH	26.24	24719451
666	Phosphorylation	EKKVEGVYTNARKQL HHHHHHHCCHHHHHH	12.72	27642862
730	Phosphorylation	SVGDKVLYGLYGIVE CCCHHHHHHHHHHHC	14.20	30576142
733	Phosphorylation	DKVLYGLYGIVEHSG HHHHHHHHHHHCCCC	10.63	30576142
747	Phosphorylation	GSMREGHYTAYVKVR CCCCCCEEEEEEEEE	12.15	30576142
765	Phosphorylation	RKLSEHNTKKKNVPG CCCCCCCCCCCCCCC	46.26	24114839

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP45_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP45_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP45_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDK1_HUMAN	CDK1	physical	19615732
FLNA_HUMAN	FLNA	physical	19615732
MYH9_HUMAN	MYH9	physical	19615732
MYH10_HUMAN	MYH10	physical	19615732
MYL6_HUMAN	MYL6	physical	19615732
PK3CG_HUMAN	PIK3CG	physical	19615732
RPB7_HUMAN	POLR2G	physical	19615732
SAFB1_HUMAN	SAFB	physical	19615732
SF3A2_HUMAN	SF3A2	physical	19615732
RTCA_HUMAN	RTCA	physical	19615732
SYFM_HUMAN	FARS2	physical	19615732
RALY_HUMAN	RALY	physical	19615732
COR1C_HUMAN	CORO1C	physical	19615732
RBMX_HUMAN	RBMX	physical	19615732
TMOD3_HUMAN	TMOD3	physical	19615732
NOP53_HUMAN	GLTSCR2	physical	19615732
ZFR_HUMAN	ZFR	physical	19615732
SRBD1_HUMAN	SRBD1	physical	19615732
YLPM1_HUMAN	YLPM1	physical	19615732
ML12B_HUMAN	MYL12B	physical	19615732
SLX4_HUMAN	SLX4	physical	25538220
ERCC1_HUMAN	ERCC1	physical	25538220
XPF_HUMAN	ERCC4	physical	25538220
MYH10_HUMAN	MYH10	physical	25538220
RBMX_HUMAN	RBMX	physical	25538220
ML12B_HUMAN	MYL12B	physical	25538220
ZFR_HUMAN	ZFR	physical	25538220
MYH9_HUMAN	MYH9	physical	25538220

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.