| UniProt ID | TRAK2_HUMAN | |
|---|---|---|
| UniProt AC | O60296 | |
| Protein Name | Trafficking kinesin-binding protein 2 | |
| Gene Name | TRAK2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 914 | |
| Subcellular Localization | Cytoplasm. Early endosome. Mitochondrion. Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner (By similarity).. | |
| Protein Description | May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.. | |
| Protein Sequence | MSQSQNAIFTSPTGEENLMNSNHRDSESITDVCSNEDLPEVELVSLLEEQLPQYRLKVDTLFLYENQDWTQSPHQRQHASDALSPVLAEETFRYMILGTDRVEQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRNHVLSEQNESLEEQLGQAFDQVNQLQHELCKKDELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQLEMLQEKLKELEEENMALRSKACHIKTETVTYEEKEQQLVSDCVKELRETNAQMSRMTEELSGKSDELIRYQEELSSLLSQIVDLQHKLKEHVIEKEELKLHLQASKDAQRQLTMELHELQDRNMECLGMLHESQEEIKELRSRSGPTAHLYFSQSYGAFTGESLAAEIEGTMRKKLSLDEESSLFKQKAQQKRVFDTVRIANDTRGRSISFPALLPIPGSNRSSVIMTAKPFESGLQQTEDKSLLNQGSSSEEVAGSSQKMGQPGPSGDSDLATALHRLSLRRQNYLSEKQFFAEEWQRKIQVLADQKEGVSGCVTPTESLASLCTTQSEITDLSSASCLRGFMPEKLQIVKPLEGSQTLYHWQQLAQPNLGTILDPRPGVITKGFTQLPGDAIYHISDLEEDEEEGITFQVQQPLEVEEKLSTSKPVTGIFLPPITSAGGPVTVATANPGKCLSCTNSTFTFTTCRILHPSDITQVTPSSGFPSLSCGSSGSSSSNTAVNSPALSYRLSIGESITNRRDSTTTFSSTMSLAKLLQERGISAKVYHSPISENPLQPLPKSLAIPSTPPNSPSHSPCPSPLPFEPRVHLSENFLASRPAETFLQEMYGLRPSRNPPDVGQLKMNLVDRLKRLGIARVVKNPGAQENGRCQEAEIGPQKPDSAVYLNSGSSLLGGLRRNQSLPVIMGSFAAPVCTSSPKMGVLKED | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 80 | Phosphorylation | PHQRQHASDALSPVL HHHHHHHHHHHHHHH | 22.69 | 29255136 | |
| 84 | Phosphorylation | QHASDALSPVLAEET HHHHHHHHHHHHHHH | 18.06 | 29255136 | |
| 99 | Phosphorylation | FRYMILGTDRVEQMT HHHHHHCCHHHHHHH | 19.72 | 30257219 | |
| 107 | Ubiquitination | DRVEQMTKTYNDIDM HHHHHHHHHHHHHHH | 43.60 | - | |
| 107 | Ubiquitination | DRVEQMTKTYNDIDM HHHHHHHHHHHHHHH | 43.60 | - | |
| 116 | Phosphorylation | YNDIDMVTHLLAERD HHHHHHHHHHHHHCH | 10.52 | 30257219 | |
| 138 | Ubiquitination | RIGQALLKRNHVLSE HHHHHHHHHCCCCCC | 52.59 | - | |
| 138 | Ubiquitination | RIGQALLKRNHVLSE HHHHHHHHHCCCCCC | 52.59 | - | |
| 192 | Phosphorylation | SETDSSCSTPLRFNE CCCCCCCCCCCCCCC | 34.70 | 24719451 | |
| 200 | Phosphorylation | TPLRFNESFSLSQGL CCCCCCCCCCCHHHH | 22.65 | 27251275 | |
| 202 | Phosphorylation | LRFNESFSLSQGLLQ CCCCCCCCCHHHHHH | 36.07 | 27251275 | |
| 236 | Phosphorylation | SKACHIKTETVTYEE HHHHCCEECEECHHH | 35.96 | 26307563 | |
| 238 | Phosphorylation | ACHIKTETVTYEEKE HHCCEECEECHHHHH | 24.31 | 26307563 | |
| 240 | Phosphorylation | HIKTETVTYEEKEQQ CCEECEECHHHHHHH | 32.41 | 26307563 | |
| 241 | Phosphorylation | IKTETVTYEEKEQQL CEECEECHHHHHHHH | 20.11 | 26307563 | |
| 254 | Ubiquitination | QLVSDCVKELRETNA HHHHHHHHHHHHHHH | 58.31 | 29967540 | |
| 273 | Ubiquitination | MTEELSGKSDELIRY HHHHHCCCHHHHHHH | 51.89 | - | |
| 273 | Ubiquitination | MTEELSGKSDELIRY HHHHHCCCHHHHHHH | 51.89 | - | |
| 280 | Phosphorylation | KSDELIRYQEELSSL CHHHHHHHHHHHHHH | 17.18 | 18491316 | |
| 285 | Phosphorylation | IRYQEELSSLLSQIV HHHHHHHHHHHHHHH | 23.40 | 18491316 | |
| 289 | Phosphorylation | EELSSLLSQIVDLQH HHHHHHHHHHHHHHH | 24.13 | - | |
| 299 | Acetylation | VDLQHKLKEHVIEKE HHHHHHHHHHHCCHH | 51.05 | 20167786 | |
| 299 | Ubiquitination | VDLQHKLKEHVIEKE HHHHHHHHHHHCCHH | 51.05 | 29967540 | |
| 316 | Ubiquitination | KLHLQASKDAQRQLT HHHHHHCHHHHHHHH | 61.16 | 29967540 | |
| 385 | Ubiquitination | IEGTMRKKLSLDEES CHHHHHHHCCCCCCH | 32.70 | 29967540 | |
| 387 | Phosphorylation | GTMRKKLSLDEESSL HHHHHHCCCCCCHHH | 42.53 | 29802988 | |
| 393 | Phosphorylation | LSLDEESSLFKQKAQ CCCCCCHHHHHHHHH | 40.90 | 24719451 | |
| 396 | Ubiquitination | DEESSLFKQKAQQKR CCCHHHHHHHHHHCC | 57.07 | 29967540 | |
| 418 | Phosphorylation | ANDTRGRSISFPALL CCCCCCCCCCCCEEE | 25.96 | 25850435 | |
| 420 | Phosphorylation | DTRGRSISFPALLPI CCCCCCCCCCEEEEC | 26.82 | 25850435 | |
| 430 | Phosphorylation | ALLPIPGSNRSSVIM EEEECCCCCCCCEEE | 24.58 | 26074081 | |
| 459 | Phosphorylation | KSLLNQGSSSEEVAG HHHHCCCCCHHHHCC | 22.41 | 27251275 | |
| 460 | Phosphorylation | SLLNQGSSSEEVAGS HHHCCCCCHHHHCCC | 48.90 | 26657352 | |
| 461 | Phosphorylation | LLNQGSSSEEVAGSS HHCCCCCHHHHCCCC | 39.20 | 27251275 | |
| 490 | Phosphorylation | ATALHRLSLRRQNYL HHHHHHHHHHHCCCC | 21.56 | 23532336 | |
| 496 | Phosphorylation | LSLRRQNYLSEKQFF HHHHHCCCCCHHHHH | 11.85 | 23663014 | |
| 498 | Phosphorylation | LRRQNYLSEKQFFAE HHHCCCCCHHHHHHH | 32.18 | 23663014 | |
| 510 | Ubiquitination | FAEEWQRKIQVLADQ HHHHHHHHHHHHHHC | 23.53 | 29967540 | |
| 526 | Phosphorylation | EGVSGCVTPTESLAS CCCCCCCCCHHHHHH | 28.68 | 27251275 | |
| 528 | Phosphorylation | VSGCVTPTESLASLC CCCCCCCHHHHHHHC | 28.92 | 27251275 | |
| 546 | Phosphorylation | SEITDLSSASCLRGF HHHCCCCHHHHHCCC | 31.34 | 24275569 | |
| 548 | Phosphorylation | ITDLSSASCLRGFMP HCCCCHHHHHCCCCC | 18.68 | 24275569 | |
| 567 | Phosphorylation | IVKPLEGSQTLYHWQ EEECCCCCCCHHHHH | 15.60 | 27251275 | |
| 569 | Phosphorylation | KPLEGSQTLYHWQQL ECCCCCCCHHHHHHH | 30.86 | 27251275 | |
| 674 | Phosphorylation | TNSTFTFTTCRILHP CCCCEEEEEEEEECH | 23.17 | - | |
| 675 | Phosphorylation | NSTFTFTTCRILHPS CCCEEEEEEEEECHH | 8.80 | - | |
| 688 | Phosphorylation | PSDITQVTPSSGFPS HHHCCCCCCCCCCCC | 13.97 | - | |
| 691 | Phosphorylation | ITQVTPSSGFPSLSC CCCCCCCCCCCCCCC | 45.73 | - | |
| 708 | Phosphorylation | SGSSSSNTAVNSPAL CCCCCCCCCCCCCCH | 33.65 | - | |
| 731 | Phosphorylation | SITNRRDSTTTFSST CCCCCCCCCCCHHHH | 26.33 | 28857561 | |
| 732 | Phosphorylation | ITNRRDSTTTFSSTM CCCCCCCCCCHHHHH | 33.86 | 28348404 | |
| 733 | Phosphorylation | TNRRDSTTTFSSTMS CCCCCCCCCHHHHHH | 29.78 | 28348404 | |
| 734 | Phosphorylation | NRRDSTTTFSSTMSL CCCCCCCCHHHHHHH | 22.93 | 28348404 | |
| 736 | Phosphorylation | RDSTTTFSSTMSLAK CCCCCCHHHHHHHHH | 23.86 | 30206219 | |
| 737 | Phosphorylation | DSTTTFSSTMSLAKL CCCCCHHHHHHHHHH | 24.76 | 30206219 | |
| 738 | Phosphorylation | STTTFSSTMSLAKLL CCCCHHHHHHHHHHH | 15.02 | 28857561 | |
| 740 | Phosphorylation | TTFSSTMSLAKLLQE CCHHHHHHHHHHHHH | 25.84 | 28857561 | |
| 751 | Phosphorylation | LLQERGISAKVYHSP HHHHCCCCCEEECCC | 25.51 | - | |
| 755 | Phosphorylation | RGISAKVYHSPISEN CCCCCEEECCCCCCC | 8.89 | 23312004 | |
| 757 | Phosphorylation | ISAKVYHSPISENPL CCCEEECCCCCCCCC | 13.26 | 23312004 | |
| 760 | Phosphorylation | KVYHSPISENPLQPL EEECCCCCCCCCCCC | 34.40 | 23312004 | |
| 770 | Phosphorylation | PLQPLPKSLAIPSTP CCCCCCCCCCCCCCC | 22.54 | 25850435 | |
| 775 | Phosphorylation | PKSLAIPSTPPNSPS CCCCCCCCCCCCCCC | 47.64 | 26657352 | |
| 776 | Phosphorylation | KSLAIPSTPPNSPSH CCCCCCCCCCCCCCC | 37.09 | 28348404 | |
| 780 | Phosphorylation | IPSTPPNSPSHSPCP CCCCCCCCCCCCCCC | 33.29 | 22617229 | |
| 782 | Phosphorylation | STPPNSPSHSPCPSP CCCCCCCCCCCCCCC | 36.10 | 27251789 | |
| 784 | Phosphorylation | PPNSPSHSPCPSPLP CCCCCCCCCCCCCCC | 32.32 | 27251789 | |
| 788 | Phosphorylation | PSHSPCPSPLPFEPR CCCCCCCCCCCCCCC | 45.87 | 25850435 | |
| 805 | Phosphorylation | LSENFLASRPAETFL CCCCCCCCCCHHHHH | 40.73 | 25332170 | |
| 810 | Phosphorylation | LASRPAETFLQEMYG CCCCCHHHHHHHHHC | 31.58 | - | |
| 816 | Phosphorylation | ETFLQEMYGLRPSRN HHHHHHHHCCCCCCC | 16.56 | - | |
| 821 | Phosphorylation | EMYGLRPSRNPPDVG HHHCCCCCCCCCCHH | 37.95 | 24719451 | |
| 831 | Methylation | PPDVGQLKMNLVDRL CCCHHHHHCHHHHHH | 20.18 | 115979575 | |
| 870 | Phosphorylation | IGPQKPDSAVYLNSG CCCCCCCCEEEECCC | 28.32 | 27732954 | |
| 873 | Phosphorylation | QKPDSAVYLNSGSSL CCCCCEEEECCCCHH | 10.40 | 27732954 | |
| 876 | Phosphorylation | DSAVYLNSGSSLLGG CCEEEECCCCHHHHC | 37.14 | 27732954 | |
| 878 | Phosphorylation | AVYLNSGSSLLGGLR EEEECCCCHHHHCCC | 20.03 | 27732954 | |
| 879 | Phosphorylation | VYLNSGSSLLGGLRR EEECCCCHHHHCCCC | 31.01 | 27732954 | |
| 889 | Phosphorylation | GGLRRNQSLPVIMGS HCCCCCCCCCEEEEC | 37.88 | 29507054 | |
| 905 | Phosphorylation | AAPVCTSSPKMGVLK CCCCCCCCCCCCCCC | 15.47 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TRAK2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRAK2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRAK2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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