TIR1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIR1_ARATH
• UniProt AC: Q570C0
• Protein Name: Protein TRANSPORT INHIBITOR RESPONSE 1
• Gene Name: TIR1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 594
• Subcellular Localization: Nucleus .
• Protein Description: Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism. Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development. Plays a role in ethylene signaling in roots. Confers sensitivity to the virulent bacterial pathogen P.syringae..
• Protein Sequence: MQKRIALSFPEEVLEHVFSFIQLDKDRNSVSLVCKSWYEIERWCRRKVFIGNCYAVSPATVIRRFPKVRSVELKGKPHFADFNLVPDGWGGYVYPWIEAMSSSYTWLEEIRLKRMVVTDDCLELIAKSFKNFKVLVLSSCEGFSTDGLAAIAATCRNLKELDLRESDVDDVSGHWLSHFPDTYTSLVSLNISCLASEVSFSALERLVTRCPNLKSLKLNRAVPLEKLATLLQRAPQLEELGTGGYTAEVRPDVYSGLSVALSGCKELRCLSGFWDAVPAYLPAVYSVCSRLTTLNLSYATVQSYDLVKLLCQCPKLQRLWVLDYIEDAGLEVLASTCKDLRELRVFPSEPFVMEPNVALTEQGLVSVSMGCPKLESVLYFCRQMTNAALITIARNRPNMTRFRLCIIEPKAPDYLTLEPLDIGFGAIVEHCKDLRRLSLSGLLTDKVFEYIGTYAKKMEMLSVAFAGDSDLGMHHVLSGCDSLRKLEIRDCPFGDKALLANASKLETMRSLWMSSCSVSFGACKLLGQKMPKLNVEVIDERGAPDSRPESCPVERVFIYRTVAGPRFDMPGFVWNMDQDSTMRFSRQIITTNGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
510	Phosphorylation	SKLETMRSLWMSSCS HHHHHHHHHHHHHCC	18.63	23660473
514	Phosphorylation	TMRSLWMSSCSVSFG HHHHHHHHHCCHHHH	19.33	23660473
515	Phosphorylation	MRSLWMSSCSVSFGA HHHHHHHHCCHHHHH	8.36	23660473
517	Phosphorylation	SLWMSSCSVSFGACK HHHHHHCCHHHHHHH	23.81	23660473
519	Phosphorylation	WMSSCSVSFGACKLL HHHHCCHHHHHHHHH	11.15	23660473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIR1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIR1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIR1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL1_ARATH	CUL1	physical	16045473
CUL1_ARATH	CUL1	physical	12782725
SKP1A_ARATH	SKP1	physical	12782725
SKP1A_ARATH	SKP1	physical	10398681
SKP1B_ARATH	ASK2	physical	10398681
CUL1_ARATH	CUL1	physical	10398681
SKP1A_ARATH	SKP1	physical	12795696
ASK11_ARATH	SK11	physical	12795696
SKP1B_ARATH	ASK2	physical	12795696
SKP1B_ARATH	ASK2	physical	12445118
IAA7_ARATH	IAA7	physical	22171938
SKP1A_ARATH	SKP1	physical	16045473
IAA3_ARATH	SHY2	physical	22466420
IAA5_ARATH	IAA5	physical	22466420
IAA8_ARATH	IAA8	physical	22466420
IAA7_ARATH	IAA7	physical	22466420
IAA28_ARATH	IAA28	physical	22466420
SKP1A_ARATH	SKP1	physical	17410169
IAA7_ARATH	IAA7	physical	17410169
IAA7_ARATH	IAA7	physical	22912871
IAA8_ARATH	IAA8	physical	22912871
IAA17_ARATH	AXR3	physical	22912871
IAA7_ARATH	IAA7	physical	25758811
IAA3_ARATH	SHY2	physical	25758811
AUX1_ARATH	AUX1	physical	23539280
IAA3_ARATH	SHY2	physical	24591051
IAA7_ARATH	IAA7	physical	24591051
IAA17_ARATH	AXR3	physical	24591051
IAA1_ARATH	IAA1	physical	25888615
TIR1L_ARATH	AFB5	physical	24313839
IAA3_ARATH	SHY2	physical	26236497
IAA5_ARATH	IAA5	physical	26236497
IAA8_ARATH	IAA8	physical	26236497
IAA12_ARATH	IAA12	physical	26236497
IAA28_ARATH	IAA28	physical	26236497
TIR1_ARATH	TIR1	physical	27618443
SKP1A_ARATH	SKP1	physical	27618443

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.