TIR1L_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIR1L_ARATH
• UniProt AC: Q9LTX2
• Protein Name: Transport inhibitor response 1-like protein
• Gene Name: At5g49980
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 619
• Subcellular Localization: Nucleus.
• Protein Sequence: MTQDRSEMSEDDDDQQSPPLDLPSTAIADPCSSSSSPNKSRNCISNSQTFPDHVLENVLENVLQFLDSRCDRNAASLVCKSWWRVEALTRSEVFIGNCYALSPARLTQRFKRVRSLVLKGKPRFADFNLMPPDWGANFAPWVSTMAQAYPCLEKVDLKRMFVTDDDLALLADSFPGFKELILVCCEGFGTSGISIVANKCRKLKVLDLIESEVTDDEVDWISCFPEDVTCLESLAFDCVEAPINFKALEGLVARSPFLKKLRLNRFVSLVELHRLLLGAPQLTSLGTGSFSHDEEPQSEQEPDYAAAFRACKSVVCLSGFRELMPEYLPAIFPVCANLTSLNFSYANISPDMFKPIILNCHKLQVFWALDSICDEGLQAVAATCKELRELRIFPFDPREDSEGPVSELGLQAISEGCRKLESILYFCQRMTNAAVIAMSENCPELTVFRLCIMGRHRPDHVTGKPMDEGFGAIVKNCKKLTRLAVSGLLTDQAFRYMGEYGKLVRTLSVAFAGDSDMALRHVLEGCPRLQKLEIRDSPFGDVALRSGMHRYYNMRFVWMSACSLSKGCCKDIARAMPNLVVEVIGSDDDDDNRDYVETLYMYRSLDGPRNDAPKFVTIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MTQDRSEMSEDDD --CCCCHHHCCCCCC	46.04	23776212
9	Phosphorylation	TQDRSEMSEDDDDQQ CCCHHHCCCCCCCCC	33.55	23776212
17	Phosphorylation	EDDDDQQSPPLDLPS CCCCCCCCCCCCCCC	23.89	23776212
24	Phosphorylation	SPPLDLPSTAIADPC CCCCCCCCCCCCCCC	37.46	23776212
25	Phosphorylation	PPLDLPSTAIADPCS CCCCCCCCCCCCCCC	21.83	23776212
36	Phosphorylation	DPCSSSSSPNKSRNC CCCCCCCCCCCCCCC	34.15	19376835

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIR1L_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIR1L_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIR1L_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IAA5_ARATH	IAA5	physical	22466420
IAA8_ARATH	IAA8	physical	22466420
IAA7_ARATH	IAA7	physical	22466420

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASSSPECTROMETRY.
PubMed: 19376835