dbPTM

SPF27_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPF27_MOUSE
UniProt AC	Q9D287
Protein Name	Pre-mRNA-splicing factor SPF27
Gene Name	Bcas2
Organism	Mus musculus (Mouse).
Sequence Length	225
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR)..
Protein Sequence	MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELPAPSSGQKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANKENIRQDF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGTGLVAG ------CCCCCCCCC	25.01	-
94	Phosphorylation	YELPAPSSGQKNDIT EECCCCCCCCCCCHH	44.15	-
173	Phosphorylation	QRKNMQLTAGSKLRE HHHHCCCCCCHHHHH	16.45	28059163
187	Phosphorylation	EMESNWVSLVSKNYE HHHHHHHHHHHCCCE	18.05	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPF27_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPF27_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPF27_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD11B_HUMAN	CDK11B	physical	26496610
CDC5L_HUMAN	CDC5L	physical	26496610
DDX3X_HUMAN	DDX3X	physical	26496610
DDX5_HUMAN	DDX5	physical	26496610
DHX8_HUMAN	DHX8	physical	26496610
EVPL_HUMAN	EVPL	physical	26496610
PEX10_HUMAN	PEX10	physical	26496610
PLRG1_HUMAN	PLRG1	physical	26496610
PPGB_HUMAN	CTSA	physical	26496610
PRCC_HUMAN	PRCC	physical	26496610
KPCA_HUMAN	PRKCA	physical	26496610
RS20_HUMAN	RPS20	physical	26496610
U5S1_HUMAN	EFTUD2	physical	26496610
SNR40_HUMAN	SNRNP40	physical	26496610
HOME3_HUMAN	HOMER3	physical	26496610
PUM3_HUMAN	KIAA0020	physical	26496610
PRP8_HUMAN	PRPF8	physical	26496610
WWP1_HUMAN	WWP1	physical	26496610
U520_HUMAN	SNRNP200	physical	26496610
PPWD1_HUMAN	PPWD1	physical	26496610
PRP6_HUMAN	PRPF6	physical	26496610
PAIRB_HUMAN	SERBP1	physical	26496610
PRP19_HUMAN	PRPF19	physical	26496610
CRNL1_HUMAN	CRNKL1	physical	26496610
RM48_HUMAN	MRPL48	physical	26496610
WDR55_HUMAN	WDR55	physical	26496610
BRX1_HUMAN	BRIX1	physical	26496610
SYF1_HUMAN	XAB2	physical	26496610
ISY1_HUMAN	ISY1	physical	26496610
UBL5_HUMAN	UBL5	physical	26496610
CCNL2_HUMAN	CCNL2	physical	26496610
FA58A_HUMAN	FAM58A	physical	26496610
CC124_HUMAN	CCDC124	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPF27_MOUSE

Related Literatures of Post-Translational Modification