| UniProt ID | RPGF5_HUMAN | |
|---|---|---|
| UniProt AC | Q92565 | |
| Protein Name | Rap guanine nucleotide exchange factor 5 | |
| Gene Name | RAPGEF5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 580 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.. | |
| Protein Sequence | MGSSRLRVFDPHLERKDSAAALSDRELPLPTFDVPYFKYIDEEDEDDEWSSRSQSSTEDDSVDSLLSDRYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPRV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 70 | Phosphorylation | DSLLSDRYVVVSGTP HHHHCCCEEEEECCH | 11.55 | - | |
| 74 | Phosphorylation | SDRYVVVSGTPEKIL CCCEEEEECCHHHHH | 25.91 | - | |
| 76 | Phosphorylation | RYVVVSGTPEKILEH CEEEEECCHHHHHHH | 22.29 | - | |
| 111 | Acetylation | DFLLTYTVFMTTDDL HHHHHHHEECCHHHH | 1.86 | - | |
| 126 | Phosphorylation | CQALLRHYSAKKYQG HHHHHHHHCCHHHCC | 12.14 | - | |
| 127 | Phosphorylation | QALLRHYSAKKYQGK HHHHHHHCCHHHCCC | 27.73 | - | |
| 158 | Phosphorylation | VSQWIALYKDWLPED HHHHHHHHHHCCCCC | 9.62 | 18083107 | |
| 191 | Acetylation | YEYPILEKELKEFQK HHCHHHHHHHHHHHH | 65.97 | 7681865 | |
| 207 | Phosphorylation | LGMHRRHTVDEYSPQ HCCCCCCCCCCCCCC | 28.04 | 27273156 | |
| 211 | Phosphorylation | RRHTVDEYSPQKKNK CCCCCCCCCCCHHCH | 22.61 | 23403867 | |
| 212 | Phosphorylation | RHTVDEYSPQKKNKA CCCCCCCCCCHHCHH | 20.85 | 23403867 | |
| 225 | Phosphorylation | KALFHQFSLKENWLQ HHHHHHCCCCHHHHH | 31.77 | 22617229 | |
| 262 | Phosphorylation | VSVKAKVSSIAQEIL EEEEHHHHHHHHHHH | 18.47 | 25627689 | |
| 263 | Phosphorylation | SVKAKVSSIAQEILK EEEHHHHHHHHHHHH | 25.57 | 25627689 | |
| 357 | Phosphorylation | ALELMNFDWSLFNSI HHHHHCCCHHHHHCH | 29.11 | 24719451 | |
| 361 | Phosphorylation | MNFDWSLFNSIHEQE HCCCHHHHHCHHCCE | 5.86 | 24719451 | |
| 375 | Phosphorylation | ELIYFTFSRQGSGEH EEEEEEEECCCCCCC | 22.19 | 24719451 | |
| 471 | Phosphorylation | KLFSELESLTDPSLN HHHHHHHHCCCCCCC | 49.55 | 17494752 | |
| 546 | Phosphorylation | TNQFGDLSPKEHQEL CCCCCCCCHHHHHHH | 38.37 | 28348404 | |
| 555 | Phosphorylation | KEHQELKSYVNHLYV HHHHHHHHHCCEEEE | 47.11 | - | |
| 573 | Phosphorylation | QQALFELSHRIEPRV HHHHHHHHHCCCCCC | 11.97 | - | |
| 621 | Phosphorylation | ------------------------------------------------ ------------------------------------------------ | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RPGF5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RPGF5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RPGF5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RAP2A_HUMAN | RAP2A | physical | 10777494 | |
| RAP1A_HUMAN | RAP1A | physical | 10777494 | |
| RAP1A_HUMAN | RAP1A | physical | 10934204 | |
| VANG1_HUMAN | VANGL1 | physical | 21988832 | |
| ANK3_HUMAN | ANK3 | physical | 28514442 | |
| ANK1_HUMAN | ANK1 | physical | 28514442 | |
| JIP2_HUMAN | MAPK8IP2 | physical | 28514442 | |
| ANK2_HUMAN | ANK2 | physical | 28514442 | |
| DDHD2_HUMAN | DDHD2 | physical | 28514442 | |
| TBB1_HUMAN | TUBB1 | physical | 28514442 | |
| GRDN_HUMAN | CCDC88A | physical | 28514442 | |
| UBB_HUMAN | UBB | physical | 28514442 | |
| HERC1_HUMAN | HERC1 | physical | 28514442 | |
| LIPB1_HUMAN | PPFIBP1 | physical | 28514442 | |
| RICTR_HUMAN | RICTOR | physical | 28514442 | |
| PLEC_HUMAN | PLEC | physical | 28514442 | |
| ZNHI2_HUMAN | ZNHIT2 | physical | 28514442 | |
| WNK1_HUMAN | WNK1 | physical | 28514442 | |
| KAP1_HUMAN | PRKAR1B | physical | 28514442 | |
| 2A5D_HUMAN | PPP2R5D | physical | 28514442 | |
| KAPCB_HUMAN | PRKACB | physical | 28514442 | |
| PK3CB_HUMAN | PIK3CB | physical | 28514442 | |
| FLNC_HUMAN | FLNC | physical | 28514442 | |
| AT2B2_HUMAN | ATP2B2 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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