NUPR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUPR1_HUMAN
• UniProt AC: O60356
• Protein Name: Nuclear protein 1 {ECO:0000305}
• Gene Name: NUPR1 {ECO:0000312|HGNC:HGNC:29990}
• Organism: Homo sapiens (Human).
• Sequence Length: 82
• Subcellular Localization: Nucleus .
• Protein Description: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin..
• Protein Sequence: MATFPPATSAPQQPPGPEDEDSSLDESDLYSLAHSYLGGGGRKGRTKREAAANTNRPSPGGHERKLVTKLQNSERKKRGARR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	PGPEDEDSSLDESDL CCCCCCCCCCCHHHH	30.65	29514088
23	Phosphorylation	GPEDEDSSLDESDLY CCCCCCCCCCHHHHH	52.76	29514088
27	Phosphorylation	EDSSLDESDLYSLAH CCCCCCHHHHHHHHH	32.36	29514088
46	Phosphorylation	GGGRKGRTKREAAAN CCCCCCCCHHHHHHH	43.02	-
54	Phosphorylation	KREAAANTNRPSPGG HHHHHHHCCCCCCCH	28.07	23312004
58	Phosphorylation	AANTNRPSPGGHERK HHHCCCCCCCHHHHH	32.70	23312004
65	Acetylation	SPGGHERKLVTKLQN CCCHHHHHHHHHHHH	44.30	85003
69	Acetylation	HERKLVTKLQNSERK HHHHHHHHHHHHHHH	40.36	85007
73	Phosphorylation	LVTKLQNSERKKRGA HHHHHHHHHHHHHCC	26.31	29514088
76	Acetylation	KLQNSERKKRGARR- HHHHHHHHHHCCCC-	42.65	85011
76	Phosphorylation	KLQNSERKKRGARR- HHHHHHHHHHCCCC-	42.65	27251275
77	Acetylation	LQNSERKKRGARR-- HHHHHHHHHCCCC--	63.39	85015

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUPR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUPR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUPR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYOD1_HUMAN	MYOD1	physical	19723804
EP300_HUMAN	EP300	physical	11940591
CSN5_HUMAN	COPS5	physical	16300740
SET_HUMAN	SET	physical	21988832
MSL1_HUMAN	MSL1	physical	24205110
MSL1_HUMAN	MSL1	physical	19650074
MO4L1_HUMAN	MORF4L1	physical	19650074
RAN_HUMAN	RAN	physical	19650074
PTMA_HUMAN	PTMA	physical	19650074
MARE1_HUMAN	MAPRE1	physical	19650074
MPH6_HUMAN	MPHOSPH6	physical	19650074
NACAM_HUMAN	NACA	physical	19650074
NACA_HUMAN	NACA	physical	19650074
PSMD4_HUMAN	PSMD4	physical	19650074
SC11A_HUMAN	SEC11A	physical	19650074
RANG_HUMAN	RANBP1	physical	19650074
STX18_HUMAN	STX18	physical	19650074
HNRPQ_HUMAN	SYNCRIP	physical	19650074
FUS_HUMAN	FUS	physical	19650074
NONO_HUMAN	NONO	physical	19650074
RL41_HUMAN	RPL41	physical	19650074
SKAP_HUMAN	KNSTRN	physical	19650074
SEMG2_HUMAN	SEMG2	physical	28514442
SEMG1_HUMAN	SEMG1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.