CDC6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDC6_MOUSE
• UniProt AC: O89033
• Protein Name: Cell division control protein 6 homolog
• Gene Name: Cdc6
• Organism: Mus musculus (Mouse).
• Sequence Length: 562
• Subcellular Localization: Nucleus . Cytoplasm . The protein is nuclear in G1 and cytoplasmic in S-phase cells.
• Protein Description: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated..
• Protein Sequence: MPQTRSQTQATIGFPKKKLSNTLKKPNSRDCEVKLRNVQPVPTTPCVDVKLLPLSPRKRLGDDNLCNTPRLSPCSPPKLGKKENGPPRSHTWKGCRLVFDDEPTFKASPPKEQDRVRQHQIRSSSAQRSPESKADPEQKCPPEKESVCIRLFKQEGTCYQQAKLVLNTAVPDRLPAREQEMGVIRNFLKEHICGKKAGSLYLSGAPGTGKTACLSRILQDFKKEVKGFKSILLNCMSLRSAQAVFPAIAQEIGREELCRPAGKDLMRKLEKHLTAEKGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLEARENCKPQLLNFPPYTRNQIAAILQDRLSQVSKDQVLDSAAIQFCARKVSAVSGDIRKALDVCRRAIEIVESDVRSQTVLKPLSECKSPSESPVPKRVGLAHISQVISEVDGNRVTLSQENTQDSLPLQQKILVCSLLLLTRRLKIKEVTLGKLYEAYSSICRKQQVTAVDQSECLSLSGLLESRGLVGLKKNKESRLTKVSLKIEEKEIEHVLNGKAFTGNILAAGLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	GFPKKKLSNTLKKPN CCCHHHHHCCCCCCC	36.33	22067460
43	Phosphorylation	RNVQPVPTTPCVDVK ECCCCCCCCCEEEEE	43.54	28066266
44	Phosphorylation	NVQPVPTTPCVDVKL CCCCCCCCCEEEEEE	14.50	28066266
55	Phosphorylation	DVKLLPLSPRKRLGD EEEEEECCCCCCCCC	22.25	27149854
68	Phosphorylation	GDDNLCNTPRLSPCS CCCCCCCCCCCCCCC	14.59	22817900
72	Phosphorylation	LCNTPRLSPCSPPKL CCCCCCCCCCCCCCC	25.74	22817900
75	Phosphorylation	TPRLSPCSPPKLGKK CCCCCCCCCCCCCCC	47.85	22817900
108	Phosphorylation	DEPTFKASPPKEQDR CCCCCCCCCCHHHHH	42.18	30482847
123	Phosphorylation	VRQHQIRSSSAQRSP HHHHHHHCCCCCCCC	30.21	29895711
124	Phosphorylation	RQHQIRSSSAQRSPE HHHHHHCCCCCCCCC	21.61	29895711
125	Phosphorylation	QHQIRSSSAQRSPES HHHHHCCCCCCCCCC	29.66	29895711
129	Phosphorylation	RSSSAQRSPESKADP HCCCCCCCCCCCCCH	22.42	29895711
421	Phosphorylation	KPLSECKSPSESPVP CCHHHCCCCCCCCCC	45.37	22817900
425	Phosphorylation	ECKSPSESPVPKRVG HCCCCCCCCCCCHHH	35.22	22817900
553	Phosphorylation	VLNGKAFTGNILAAG HHCCCCCCCCHHHCC	33.89	29109428

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDC6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDC6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDC6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AIFM1_HUMAN	AIFM1	physical	20360068
BCLF1_HUMAN	BCLAF1	physical	20360068
CDC6_HUMAN	CDC6	physical	20360068
TR150_HUMAN	THRAP3	physical	20360068
H2B2B_MOUSE	Hist2h2bb	physical	18635963
CX6B1_HUMAN	COX6B1	physical	26496610
B4GT1_HUMAN	B4GALT1	physical	26496610
RON_HUMAN	MST1R	physical	26496610
ABCE1_HUMAN	ABCE1	physical	26496610
AP2A_HUMAN	TFAP2A	physical	26496610
RL40_HUMAN	UBA52	physical	26496610
KMT2D_HUMAN	KMT2D	physical	26496610
PRP4B_HUMAN	PRPF4B	physical	26496610
TRI14_HUMAN	TRIM14	physical	26496610
CLAP2_HUMAN	CLASP2	physical	26496610
UBP24_HUMAN	USP24	physical	26496610
BI2L1_HUMAN	BAIAP2L1	physical	26496610
DEFM_HUMAN	PDF	physical	26496610
ZN598_HUMAN	ZNF598	physical	26496610
PTGR2_HUMAN	PTGR2	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.