CD1E_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD1E_HUMAN
• UniProt AC: P15812
• Protein Name: T-cell surface glycoprotein CD1e, membrane-associated
• Gene Name: CD1E
• Organism: Homo sapiens (Human).
• Sequence Length: 388
• Subcellular Localization: T-cell surface glycoprotein CD1e, membrane-associated: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, sol
• Protein Description: T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active..
• Protein Sequence: MLLLFLLFEGLCCPGENTAAPQALQSYHLAAEEQLSFRMLQTSSFANHSWAHSEGSGWLGDLQTHGWDTVLGTIRFLKPWSHGNFSKQELKNLQSLFQLYFHSFIQIVQASAGQFQLEYPFEIQILAGCRMNAPQIFLNMAYQGSDFLSFQGISWEPSPGAGIRAQNICKVLNRYLDIKEILQSLLGHTCPRFLAGLMEAGESELKRKVKPEAWLSCGPSPGPGRLQLVCHVSGFYPKPVWVMWMRGEQEQRGTQRGDVLPNADETWYLRATLDVAAGEAAGLSCRVKHSSLGGHDLIIHWGGYSIFLILICLTVIVTLVILVVVDSRLKKQSSNKNILSPHTPSPVFLMGANTQDTKNSRHQFCLAQVSWIKNRVLKKWKTRLNQLW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	N-linked_Glycosylation	LQTSSFANHSWAHSE HHCCCCCCCCEECCC	27.93	UniProtKB CARBOHYD
78	Ubiquitination	LGTIRFLKPWSHGNF HHHHHCCCCCCCCCC	41.55	-
84	N-linked_Glycosylation	LKPWSHGNFSKQELK CCCCCCCCCCHHHHH	32.37	UniProtKB CARBOHYD
87 (in isoform 12)	Ubiquitination	-	43.59	-
87	Ubiquitination	WSHGNFSKQELKNLQ CCCCCCCHHHHHHHH	43.59	-
89 (in isoform 12)	Phosphorylation	-	66.50	24275569
102 (in isoform 12)	Ubiquitination	-	14.29	-
144 (in isoform 9)	Phosphorylation	-	19.26	24275569
170	Ubiquitination	IRAQNICKVLNRYLD HHHHHHHHHHHHHCC	46.06	-
179	Ubiquitination	LNRYLDIKEILQSLL HHHHCCHHHHHHHHH	38.07	-
188 (in isoform 7)	Phosphorylation	-	25.02	24275569
206 (in isoform 2)	Ubiquitination	-	46.23	-
206	Ubiquitination	EAGESELKRKVKPEA HHCHHHHHHCCCHHH	46.23	-
208	Ubiquitination	GESELKRKVKPEAWL CHHHHHHCCCHHHHH	53.69	-
208 (in isoform 2)	Ubiquitination	-	53.69	-
210	Ubiquitination	SELKRKVKPEAWLSC HHHHHCCCHHHHHHC	39.93	-
210 (in isoform 2)	Ubiquitination	-	39.93	-
220	Phosphorylation	AWLSCGPSPGPGRLQ HHHHCCCCCCCCCEE	27.98	23532336
243 (in isoform 6)	Phosphorylation	-	1.05	24275569
278 (in isoform 4)	Phosphorylation	-	18.48	24275569
314	Phosphorylation	FLILICLTVIVTLVI HHHHHHHHHHHHHHH	12.08	19690332
331 (in isoform 2)	Ubiquitination	-	61.06	-
333 (in isoform 2)	Phosphorylation	-	44.77	24275569
336	Ubiquitination	LKKQSSNKNILSPHT HHCCCCCCCCCCCCC	47.52	-
342 (in isoform 2)	Phosphorylation	-	47.21	-
345 (in isoform 2)	Phosphorylation	-	34.55	-
346 (in isoform 2)	Ubiquitination	-	23.29	-
354	Phosphorylation	VFLMGANTQDTKNSR EEEEECCCCCCCCCC	27.56	24275569
357	Phosphorylation	MGANTQDTKNSRHQF EECCCCCCCCCCCCH	23.47	24275569
358	Ubiquitination	GANTQDTKNSRHQFC ECCCCCCCCCCCCHH	62.30	-
361 (in isoform 2)	Ubiquitination	-	36.70	-
370	Phosphorylation	QFCLAQVSWIKNRVL CHHHHHHHHHHHHHH	15.82	-
373	Ubiquitination	LAQVSWIKNRVLKKW HHHHHHHHHHHHHHH	32.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD1E_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD1E_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD1E_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FCGRN_HUMAN	FCGRT	physical	28514442
SUSD5_HUMAN	SUSD5	physical	28514442
FND3A_HUMAN	FNDC3A	physical	28514442
C1QRF_HUMAN	C1QL1	physical	28514442
TM59L_HUMAN	TMEM59L	physical	28514442
CALX_HUMAN	CANX	physical	28514442
GPT_HUMAN	DPAGT1	physical	28514442
CTGE5_HUMAN	CTAGE5	physical	28514442
B2MG_HUMAN	B2M	physical	28514442
KCNJ8_HUMAN	KCNJ8	physical	28514442
ENTP7_HUMAN	ENTPD7	physical	28514442
BACE2_HUMAN	BACE2	physical	28514442
FA69A_HUMAN	FAM69A	physical	28514442
POMT1_HUMAN	POMT1	physical	28514442
MKS3_HUMAN	TMEM67	physical	28514442
SEM4F_HUMAN	SEMA4F	physical	28514442
MA2A2_HUMAN	MAN2A2	physical	28514442
STIM1_HUMAN	STIM1	physical	28514442
ABHEA_HUMAN	ABHD14A	physical	28514442
NCEH1_HUMAN	NCEH1	physical	28514442
MA1A2_HUMAN	MAN1A2	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
ITA7_HUMAN	ITGA7	physical	28514442
LMA2L_HUMAN	LMAN2L	physical	28514442
ANR46_HUMAN	ANKRD46	physical	28514442
CC50A_HUMAN	TMEM30A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.