| UniProt ID | BRNP3_HUMAN | |
|---|---|---|
| UniProt AC | Q76B58 | |
| Protein Name | BMP/retinoic acid-inducible neural-specific protein 3 | |
| Gene Name | BRINP3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 766 | |
| Subcellular Localization | Secreted . Mitochondrion. | |
| Protein Description | Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.. | |
| Protein Sequence | MIWRSRAGAELFSLMALWEWIALSLHCWVLAVAAVSDQHATSPFDWLLSDKGPFHRSQEYTDFVDRSRQGFSTRYKIYREFGRWKVNNLAVERRNFLGSPLPLAPEFFRNIRLLGRRPTLQQITENLIKKYGTHFLLSATLGGEESLTIFVDKRKLSKRAEGSDSTTNSSSVTLETLHQLAASYFIDRDSTLRRLHHIQIASTAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKIQLQGLQVLLPDYLQERFVQAALSYIACNSEGEFICKENDCWCHCGPKFPECNCPSMDIQAMEENLLRITETWKAYNSDFEESDEFKLFMKRLPMNYFLNTSTIMHLWTMDSNFQRRYEQLENSMKQLFLKAQKIVHKLFSLSKRCHKQPLISLPRQRTSTYWLTRIQSFLYCNENGLLGSFSEETHSCTCPNDQVVCTAFLPCTVGDASACLTCAPDNRTRCGTCNTGYMLSQGLCKPEVAESTDHYIGFETDLQDLEMKYLLQKTDRRIEVHAIFISNDMRLNSWFDPSWRKRMLLTLKSNKYKSSLVHMILGLSLQICLTKNSTLEPVLAVYVNPFGGSHSESWFMPVNENSFPDWERTKLDLPLQCYNWTLTLGNKWKTFFETVHIYLRSRIKSNGPNGNESIYYEPLEFIDPSRNLGYMKINNIQVFGYSMHFDPEAIRDLILQLDYPYTQGSQDSALLQLLEIRDRVNKLSPPGQRRLDLFSCLLRHRLKLSTSEVVRIQSALQAFNAKLPNTMDYDTTKLCS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 124 | Phosphorylation | RPTLQQITENLIKKY CCCHHHHHHHHHHHH | 22777824 | ||
| 140 | Phosphorylation | THFLLSATLGGEESL CEEEEEEECCCCEEE | - | ||
| 146 | Phosphorylation | ATLGGEESLTIFVDK EECCCCEEEEEEEEH | - | ||
| 163 | Phosphorylation | LSKRAEGSDSTTNSS HHCCCCCCCCCCCCC | 30576142 | ||
| 168 | N-linked_Glycosylation | EGSDSTTNSSSVTLE CCCCCCCCCCCCHHH | UniProtKB CARBOHYD | ||
| 176 | Phosphorylation | SSSVTLETLHQLAAS CCCCHHHHHHHHHHH | 30576142 | ||
| 183 | Phosphorylation | TLHQLAASYFIDRDS HHHHHHHHHHCCCCC | 30576142 | ||
| 190 | Phosphorylation | SYFIDRDSTLRRLHH HHHCCCCCHHHHHHH | 21406692 | ||
| 191 | Phosphorylation | YFIDRDSTLRRLHHI HHCCCCCHHHHHHHH | 21406692 | ||
| 202 | Phosphorylation | LHHIQIASTAIKVTE HHHHEEECCEEEEEE | 26330541 | ||
| 203 | Phosphorylation | HHIQIASTAIKVTET HHHEEECCEEEEEEC | 26330541 | ||
| 245 | Ubiquitination | IQLQGLQVLLPDYLQ EEECHHHHHCHHHHH | 20972266 | ||
| 273 | Ubiquitination | NSEGEFICKENDCWC CCCCCEEECCCCCEE | 29967540 | ||
| 315 | Phosphorylation | ETWKAYNSDFEESDE HHHHHHCCCCCCCHH | 26552605 | ||
| 320 | Phosphorylation | YNSDFEESDEFKLFM HCCCCCCCHHHHHHH | 26552605 | ||
| 334 | Phosphorylation | MKRLPMNYFLNTSTI HHHCCCCEECCHHHH | - | ||
| 337 | N-linked_Glycosylation | LPMNYFLNTSTIMHL CCCCEECCHHHHHHH | UniProtKB CARBOHYD | ||
| 375 | Ubiquitination | KAQKIVHKLFSLSKR HHHHHHHHHHHHHHH | 29967540 | ||
| 390 | Phosphorylation | CHKQPLISLPRQRTS HCCCCCCCCCCCCCC | 24719451 | ||
| 436 | Ubiquitination | PNDQVVCTAFLPCTV CCCCEEEEEEEECEE | - | ||
| 436 | Ubiquitination | PNDQVVCTAFLPCTV CCCCEEEEEEEECEE | 20972266 | ||
| 456 | N-linked_Glycosylation | CLTCAPDNRTRCGTC HCEECCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 495 | Ubiquitination | FETDLQDLEMKYLLQ EECCHHHHHHHHHHH | 20972266 | ||
| 508 | Ubiquitination | LQKTDRRIEVHAIFI HHHHCCCEEEEEEEE | 20972266 | ||
| 528 | Phosphorylation | LNSWFDPSWRKRMLL CCCCCCHHHHHHHHH | 26091039 | ||
| 538 | Ubiquitination | KRMLLTLKSNKYKSS HHHHHHHHCCCCHHH | 2097226 | ||
| 562 | N-linked_Glycosylation | LQICLTKNSTLEPVL HHHHHHCCCCCCEEE | UniProtKB CARBOHYD | ||
| 609 | N-linked_Glycosylation | DLPLQCYNWTLTLGN CCCEEEEEEEEEECH | UniProtKB CARBOHYD | ||
| 635 | Phosphorylation | YLRSRIKSNGPNGNE HHHHHHHHCCCCCCC | 22210691 | ||
| 641 | N-linked_Glycosylation | KSNGPNGNESIYYEP HHCCCCCCCCEEECC | UniProtKB CARBOHYD | ||
| 660 | Phosphorylation | DPSRNLGYMKINNIQ CCCCCCCEEEECCEE | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BRNP3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BRNP3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BRNP3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| BRNP2_HUMAN | BRINP2 | physical | 28514442 | |
| DYR2_HUMAN | DHFRL1 | physical | 28514442 | |
| TXD15_HUMAN | TXNDC15 | physical | 28514442 | |
| BUB1_HUMAN | BUB1 | physical | 28514442 | |
| TBA4A_HUMAN | TUBA4A | physical | 28514442 | |
| K0232_HUMAN | KIAA0232 | physical | 28514442 | |
| TBA1A_HUMAN | TUBA1A | physical | 28514442 | |
| CBWD1_HUMAN | CBWD1 | physical | 28514442 | |
| NRP2_HUMAN | NRP2 | physical | 28514442 | |
| ATG2B_HUMAN | ATG2B | physical | 28514442 | |
| EDEM2_HUMAN | EDEM2 | physical | 28514442 | |
| DNJB9_HUMAN | DNAJB9 | physical | 28514442 | |
| LRP5_HUMAN | LRP5 | physical | 28514442 | |
| GRDN_HUMAN | CCDC88A | physical | 28514442 | |
| FAT1_HUMAN | FAT1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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