BRNP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BRNP2_HUMAN
• UniProt AC: Q9C0B6
• Protein Name: BMP/retinoic acid-inducible neural-specific protein 2
• Gene Name: BRINP2
• Organism: Homo sapiens (Human).
• Sequence Length: 783
• Subcellular Localization: Secreted .
• Protein Description: Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition..
• Protein Sequence: MRWQCGTRFRGLRPAVAPWTALLALGLPGWVLAVSATAAAVVPEQHASVAGQHPLDWLLTDRGPFHRAQEYADFMERYRQGFTTRYRIYREFARWKVNNLALERKDFFSLPLPLAPEFIRNIRLLGRRPNLQQVTENLIKKYGTHFLLSATLGGEESLTIFVDKQKLGRKTETTGGASIIGGSGNSTAVSLETLHQLAASYFIDRESTLRRLHHIQIATGAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKVQLLGLQVLLPEYLRERFVAAALSYITCSSEGELVCKENDCWCKCSPTFPECNCPDADIQAMEDSLLQIQDSWATHNRQFEESEEFQALLKRLPDDRFLNSTAISQFWAMDTSLQHRYQQLGAGLKVLFKKTHRILRRLFNLCKRCHRQPRFRLPKERSLSYWWNRIQSLLYCGESTFPGTFLEQSHSCTCPYDQSSCQGPIPCALGEGPACAHCAPDNSTRCGSCNPGYVLAQGLCRPEVAESLENFLGLETDLQDLELKYLLQKQDSRIEVHSIFISNDMRLGSWFDPSWRKRMLLTLKSNKYKPGLVHVMLALSLQICLTKNSTLEPVMAIYVNPFGGSHSESWFMPVNEGSFPDWERTNVDAAAQCQNWTITLGNRWKTFFETVHVYLRSRIKSLDDSSNETIYYEPLEMTDPSKNLGYMKINTLQVFGYSLPFDPDAIRDLILQLDYPYTQGSQDSALLQLIELRDRVNQLSPPGKVRLDLFSCLLRHRLKLANNEVGRIQSSLRAFNSKLPNPVEYETGKLCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	YADFMERYRQGFTTR HHHHHHHHHCCCCHH		24043423
83	Phosphorylation	ERYRQGFTTRYRIYR HHHHCCCCHHHHHHH		24043423
84	Phosphorylation	RYRQGFTTRYRIYRE HHHCCCCHHHHHHHH		24043423
151	Phosphorylation	THFLLSATLGGEESL CEEEEEEECCCCCEE		-
157	Phosphorylation	ATLGGEESLTIFVDK EECCCCCEEEEEECH		-
185	N-linked_Glycosylation	SIIGGSGNSTAVSLE EEECCCCCCCEECHH		UniProtKB CARBOHYD
240	Ubiquitination	GCSNYDNLDSVSSVL CCCCCCCCCCCCEEE		20972266
354	N-linked_Glycosylation	LPDDRFLNSTAISQF CCCCCCCCHHHHHHH		UniProtKB CARBOHYD
473	N-linked_Glycosylation	CAHCAPDNSTRCGSC CCCCCCCCCCCCCCC		UniProtKB CARBOHYD
545	Phosphorylation	LGSWFDPSWRKRMLL CCCCCCHHHHHHHHH		26091039
555	Ubiquitination	KRMLLTLKSNKYKPG HHHHHHHHCCCCCCC		20972266
579	N-linked_Glycosylation	LQICLTKNSTLEPVM HHHHHCCCCCCCCEE		UniProtKB CARBOHYD
626	N-linked_Glycosylation	DAAAQCQNWTITLGN HHHHHHCCEEEEECH		UniProtKB CARBOHYD
658	N-linked_Glycosylation	KSLDDSSNETIYYEP HCCCCCCCCEEEEEE		UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BRNP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BRNP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BRNP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RDH14_HUMAN	RDH14	physical	28514442
AT5G1_HUMAN	ATP5G1	physical	28514442
CALX_HUMAN	CANX	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
EDEM2_HUMAN	EDEM2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.