ZN692_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN692_HUMAN
• UniProt AC: Q9BU19
• Protein Name: Zinc finger protein 692
• Gene Name: ZNF692
• Organism: Homo sapiens (Human).
• Sequence Length: 519
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MASSPAVDVSCRRREKRRQLDARRSKCRIRLGGHMEQWCLLKERLGFSLHSQLAKFLLDRYTSSGCVLCAGPEPLPPKGLQYLVLLSHAHSRECSLVPGLRGPGGQDGGLVWECSAGHTFSWGPSLSPTPSEAPKPASLPHTTRRSWCSEATSGQELADLESEHDERTQEARLPRRVGPPPETFPPPGEEEGEEEEDNDEDEEEMLSDASLWTYSSSPDDSEPDAPRLLPSPVTCTPKEGETPPAPAALSSPLAVPALSASSLSSRAPPPAEVRVQPQLSRTPQAAQQTEALASTGSQAQSAPTPAWDEDTAQIGPKRIRKAAKRELMPCDFPGCGRIFSNRQYLNHHKKYQHIHQKSFSCPEPACGKSFNFKKHLKEHMKLHSDTRDYICEFCARSFRTSSNLVIHRRIHTGEKPLQCEICGFTCRQKASLNWHQRKHAETVAALRFPCEFCGKRFEKPDSVAAHRSKSHPALLLAPQESPSGPLEPCPSISAPGPLGSSEGSRPSASPQAPTLLPQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASSPAVDVS -----CCCCCCCCHH	35.24	23401153
4	Phosphorylation	----MASSPAVDVSC ----CCCCCCCCHHH	13.82	22199227
8 (in isoform 5)	Phosphorylation	-	28.81	26552605
9 (in isoform 5)	Phosphorylation	-	4.71	24043423
10	Phosphorylation	SSPAVDVSCRRREKR CCCCCCHHHHHHHHH	9.46	26552605
15 (in isoform 5)	Phosphorylation	-	49.45	26552605
48	Phosphorylation	LKERLGFSLHSQLAK HHHHHCCCHHHHHHH	24.31	22210691
51	Phosphorylation	RLGFSLHSQLAKFLL HHCCCHHHHHHHHHH	31.98	22210691
61	Phosphorylation	AKFLLDRYTSSGCVL HHHHHHHHCCCCEEE	15.61	-
62	Phosphorylation	KFLLDRYTSSGCVLC HHHHHHHCCCCEEEE	19.81	-
63	Phosphorylation	FLLDRYTSSGCVLCA HHHHHHCCCCEEEEE	18.79	-
64	Phosphorylation	LLDRYTSSGCVLCAG HHHHHCCCCEEEEEC	28.54	-
115	Phosphorylation	GGLVWECSAGHTFSW CCEEEEECCCCEEEC	26.27	28348404
119	Phosphorylation	WECSAGHTFSWGPSL EEECCCCEEECCCCC	20.60	28348404
121	Phosphorylation	CSAGHTFSWGPSLSP ECCCCEEECCCCCCC	32.07	28348404
125	Phosphorylation	HTFSWGPSLSPTPSE CEEECCCCCCCCCCC	37.23	28348404
127	Phosphorylation	FSWGPSLSPTPSEAP EECCCCCCCCCCCCC	30.94	28348404
146	Phosphorylation	LPHTTRRSWCSEATS CCCCCCCHHHCCCCC	29.19	28450419
149	Phosphorylation	TTRRSWCSEATSGQE CCCCHHHCCCCCCCH	24.81	22210691
152	Phosphorylation	RSWCSEATSGQELAD CHHHCCCCCCCHHHH	29.37	27732954
153	Phosphorylation	SWCSEATSGQELADL HHHCCCCCCCHHHHH	45.59	27732954
162	Phosphorylation	QELADLESEHDERTQ CHHHHHHHHCHHHHH	47.75	28985074
176 (in isoform 2)	Phosphorylation	-	35.49	-
221	Phosphorylation	YSSSPDDSEPDAPRL ECCCCCCCCCCCCCC	59.41	15302935
231	Phosphorylation	DAPRLLPSPVTCTPK CCCCCCCCCCCCCCC	31.78	23401153
234	Phosphorylation	RLLPSPVTCTPKEGE CCCCCCCCCCCCCCC	17.66	30266825
236	Phosphorylation	LPSPVTCTPKEGETP CCCCCCCCCCCCCCC	28.20	23927012
242	Phosphorylation	CTPKEGETPPAPAAL CCCCCCCCCCCCCHH	45.49	28122231
250	Phosphorylation	PPAPAALSSPLAVPA CCCCCHHCCCCHHHC	25.78	25850435
251	Phosphorylation	PAPAALSSPLAVPAL CCCCHHCCCCHHHCC	25.45	25850435
261	Phosphorylation	AVPALSASSLSSRAP HHHCCCHHHCCCCCC	28.56	28985074
282	Phosphorylation	VQPQLSRTPQAAQQT CCCCCCCCHHHHHHH	19.17	25627689
384	Phosphorylation	KEHMKLHSDTRDYIC HHHHHHCCCCHHHHH	51.63	28555341
393	Ubiquitination	TRDYICEFCARSFRT CHHHHHHHHHHHHCC	3.24	29967540
412	Phosphorylation	VIHRRIHTGEKPLQC EEEEEECCCCCCEEE	44.67	21712546
438	Ubiquitination	SLNWHQRKHAETVAA CCCHHHHHCHHHHHH	40.37	29967540
443	Ubiquitination	QRKHAETVAALRFPC HHHCHHHHHHHHCCC	1.90	29967540
462	Phosphorylation	KRFEKPDSVAAHRSK CCCCCCCCCHHHCCC	23.37	28555341
470	Phosphorylation	VAAHRSKSHPALLLA CHHHCCCCCCEEEEC	35.63	22817900
491	Phosphorylation	GPLEPCPSISAPGPL CCCCCCCCCCCCCCC	35.57	28348404
493	Phosphorylation	LEPCPSISAPGPLGS CCCCCCCCCCCCCCC	32.52	28348404
500	Phosphorylation	SAPGPLGSSEGSRPS CCCCCCCCCCCCCCC	32.66	28348404
501	Phosphorylation	APGPLGSSEGSRPSA CCCCCCCCCCCCCCC	44.15	28348404
504	Phosphorylation	PLGSSEGSRPSASPQ CCCCCCCCCCCCCCC	36.65	28348404
507	Phosphorylation	SSEGSRPSASPQAPT CCCCCCCCCCCCCCC	40.02	28348404
509	Phosphorylation	EGSRPSASPQAPTLL CCCCCCCCCCCCCCC	23.14	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
470	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS
470	S	Phosphorylation	Kinase	AMPK-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN692_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN692_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KBTB8_HUMAN	KBTBD8	physical	28514442
RAD18_HUMAN	RAD18	physical	28514442
NSD1_HUMAN	NSD1	physical	28514442
FBX11_HUMAN	FBXO11	physical	28514442
3HIDH_HUMAN	HIBADH	physical	28514442
MGAP_HUMAN	MGA	physical	28514442
RPA49_HUMAN	POLR1E	physical	28514442
CR025_HUMAN	C18orf25	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
SPT2_HUMAN	SPTY2D1	physical	28514442
IMP4_HUMAN	IMP4	physical	28514442
NSD2_HUMAN	WHSC1	physical	28514442
DDX24_HUMAN	DDX24	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
REXO4_HUMAN	REXO4	physical	28514442
DDX31_HUMAN	DDX31	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
RPF2_HUMAN	RPF2	physical	28514442
ASTE1_HUMAN	ASTE1	physical	28514442
CEBPZ_HUMAN	CEBPZ	physical	28514442
RRP7A_HUMAN	RRP7A	physical	28514442
DDX54_HUMAN	DDX54	physical	28514442
DDX27_HUMAN	DDX27	physical	28514442
TRM1L_HUMAN	TRMT1L	physical	28514442
POP1_HUMAN	POP1	physical	28514442
PWP2_HUMAN	PWP2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.