SART3_MOUSE - dbPTM
SART3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SART3_MOUSE
UniProt AC Q9JLI8
Protein Name Squamous cell carcinoma antigen recognized by T-cells 3 {ECO:0000305}
Gene Name Sart3 {ECO:0000312|MGI:MGI:1858230}
Organism Mus musculus (Mouse).
Sequence Length 962
Subcellular Localization Nucleus, nucleoplasm . Nucleus, Cajal body . Nucleus speckle . Cytoplasm .
Protein Description U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly. May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (By similarity). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC. [PubMed: 21447833]
Protein Sequence MATTAASSASEPEVEPQAGPEAEGEEDEAKPAGVQRKVLSGAVAAEAAEAKGPGWDLQREGASGSDGDEEDAMASSAESSAGEDEWEYDEEEEKNQLEIERLEEQLSINGYDYNCHVELIRLLRLEGELSRVRAARQKMSELFPLTEELWLEWLHDEISMAMDGLDREHVYELFERAVKDYICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLAIWEAYREFESAIVEAARLEKVHSLFRRQLAIPLYEMEATFAEYEEWSEEPMPESVLQSYQKALGQLEKYKPYEEALLQAEAPRLAEYQAYIDFEMKIGDPARIQLIFERALVENCLVPDLWIRYSQYLDRQLKVKDLVLSVHSRAVRNCPWTVALWSRYLLAMERHGLDHQTISATFENALSAGFIQATDYVEIWQVYLDYLRRRVDFRQDSSKELEELRSMFTRALEYLQQEVEERFSESGDPSCLIMQSWARVEARLCNNMQKARELWDSIMTRGNAKYANMWLEYYNLERAHGDTQHCRKALHRAVQCTSDYPEHVCEVLLTMERTEGTLEDWDLAIQKTETRLARVNEQRMKAAEKEAALVQQEEEKAEQRKKVRAEKKALKKKKKTRGADKRREDEDEENEWGEEEEEQPSKRRRTENSLASGEASAMKEETELSGKCLTIDVGPPSKQKEKAASLKRDMPKVAHDSSKDSVTVFVSNLPYSIEEPEVKLRPLFEVCGEVVQIRPIFSNRGDFRGYCYVEFGEEKSAQQALELDRKIVEGRPMFVSPCVDKSKNPDFKVFRYSTTLEKHKLFISGLPFSCTKEELEDICKAHGTVKDLRLVTNRAGKPKGLAYVEYENESQASQAVMKMDGMTIRENVIKVAISNPPQRKVPEKPEVRTAPGAPMLPRQMYGARGKGRTQLSLLPRALQRQGAAPQAENGPAPGPAVAPSVATEAPKMSNADFAKLLLRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MATTAASSA
------CCCCCCCCC		17.41-
3Phosphorylation-----MATTAASSAS
-----CCCCCCCCCC		18.7026160508
4Phosphorylation----MATTAASSASE
----CCCCCCCCCCC		15.6426160508
7Phosphorylation-MATTAASSASEPEV
-CCCCCCCCCCCCCC		24.7926160508
8PhosphorylationMATTAASSASEPEVE
CCCCCCCCCCCCCCC		30.9626824392
10PhosphorylationTTAASSASEPEVEPQ
CCCCCCCCCCCCCCC		56.4826824392
40PhosphorylationGVQRKVLSGAVAAEA
CHHHHHHHHHHHHHH		27.9128833060
216PhosphorylationSVFERALSSVGLHMT
HHHHHHHHHCCCCHH		23.22-
217PhosphorylationVFERALSSVGLHMTK
HHHHHHHHCCCCHHH		22.51-
487S-palmitoylationARVEARLCNNMQKAR
HHHHHHHHCCHHHHH		2.6326165157
569AcetylationDWDLAIQKTETRLAR
HHHHHHHHHHHHHHH		42.0623236377
648PhosphorylationQPSKRRRTENSLASG
CCCHHHHHHHHHHHC		37.3928973931
651PhosphorylationKRRRTENSLASGEAS
HHHHHHHHHHHCHHH		21.0527841257
667PhosphorylationMKEETELSGKCLTID
HHHHHCCCCCEEEEE		29.9427841257
794PhosphorylationPDFKVFRYSTTLEKH
CCCCEEEEECCHHHC		10.0229176673
795PhosphorylationDFKVFRYSTTLEKHK
CCCEEEEECCHHHCC		15.6229176673
796PhosphorylationFKVFRYSTTLEKHKL
CCEEEEECCHHHCCE		26.8529176673
797PhosphorylationKVFRYSTTLEKHKLF
CEEEEECCHHHCCEE		27.2929176673
814AcetylationGLPFSCTKEELEDIC
CCCCCCCHHHHHHHH		54.2222826441
852PhosphorylationYVEYENESQASQAVM
EEEECCHHHHHHHHH		42.50-
906MethylationPRQMYGARGKGRTQL
CCHHCCCCCCCHHHH		42.89-
914PhosphorylationGKGRTQLSLLPRALQ
CCCHHHHHHHHHHHH		20.3127149854
957UbiquitinationMSNADFAKLLLRK--
CCCHHHHHHHCCC--		39.3922790023
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SART3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SART3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SART3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FMR1_HUMANFMR1physical
26496610
TZAP_HUMANZBTB48physical
26496610
HNRPU_HUMANHNRNPUphysical
26496610
HSP74_HUMANHSPA4physical
26496610
IMA1_HUMANKPNA2physical
26496610
STXB1_HUMANSTXBP1physical
26496610
ICAM5_HUMANICAM5physical
26496610
1433B_HUMANYWHABphysical
26496610
FXR1_HUMANFXR1physical
26496610
PRP4B_HUMANPRPF4Bphysical
26496610
PRP4_HUMANPRPF4physical
26496610
PRPF3_HUMANPRPF3physical
26496610
IF4A3_HUMANEIF4A3physical
26496610
MYCB2_HUMANMYCBP2physical
26496610
P3H1_HUMANP3H1physical
26496610
STPAP_HUMANTUT1physical
26496610
LENG1_HUMANLENG1physical
26496610
SYTC2_HUMANTARSL2physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SART3_MOUSE

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory