dbPTM

PAKM_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PAKM_DROME
UniProt AC	Q9VXE5
Protein Name	Serine/threonine-protein kinase PAK mbt
Gene Name	mbt {ECO:0000312\|EMBL:AAF48629.2}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	639
Subcellular Localization	Cell junction, adherens junction . Cell membrane Peripheral membrane protein . Apical membrane sites of adherens junctions of developing photoreceptor cells.
Protein Description	Involved in neurogenesis of the adult central nervous system, and together with Cdc42, regulates photoreceptor cell morphogenesis. Phosphorylates exogenous substrates when activated by Cdc42..
Protein Sequence	MFSKKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEITPTEILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMAPGAHPMMSHGPGMMMPPETGGIVLPKTSHVARSNSLRSSSPPRVRRVANVPPSVPEEEGPPAAGTPGVGGASSGGFKPPGAHPSLLYNSQHAHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGSVASGTRSNHSHTNNGNSGGSYPPMYPTSHQQQQQQQQQAKQGGDQNQNPLHPHAHPHPHHHQHLAKSASRASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQAGPPSLLVPLMRNARHHP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
148	Phosphorylation	SNSLRSSSPPRVRRV CCCCCCCCCCCEEEE	39.92	19429919
333	Phosphorylation	AQQASGASGGAAGQP HHHHHCCCCCCCCCC	41.08	22817900
521	Phosphorylation	QELPKRKSLVGTPYW HHCCCCCCCCCCCCC	32.11	19429919
525	Phosphorylation	KRKSLVGTPYWMSPE CCCCCCCCCCCCCHH	13.01	12490550

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PAKM_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PAKM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PAKM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL7A_DROME	RpL7A	physical	14605208
MARF_DROME	Marf	physical	14605208
RDX_DROME	rdx	physical	14605208
DLL_DROME	Dll	physical	15575970
RAD51_DROME	spn-A	physical	15575970
CDC42_DROME	Cdc42	physical	12490550
LIMK1_DROME	LIMK1	genetic	17097274
CADF_DROME	tsr	genetic	17097274
SSH_DROME	ssh	genetic	17097274
PAKM_DROME	mbt	physical	12490550
CDC42_DROME	Cdc42	physical	23571212
DCTN2_DROME	Dmn	physical	17597574

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PAKM_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521 AND THR-525, ANDMASS SPECTROMETRY.	18327897 [Abstract]