NLK_CAEEL - dbPTM
NLK_CAEEL - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NLK_CAEEL
UniProt AC Q9U9Y8
Protein Name Serine/threonine kinase NLK {ECO:0000250|UniProtKB:O54949}
Gene Name lit-1 {ECO:0000312|EMBL:AAD39815.1, ECO:0000312|WormBase:W06F12.1e}
Organism Caenorhabditis elegans.
Sequence Length 634
Subcellular Localization Cytoplasm, cell cortex . Nucleus . Located in the anterior cell cortex before and during asymmetric cell division. After division, located preferentially in the nucleus of the posterior daughter cell.
Protein Description Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T-cell division asymmetry. Lit-1/wrm-1 complex regulates pop-1 localization and is required for pop-1/par-5 interaction..
Protein Sequence MVSWGRGKDAYYLYISREQEEDDDDSLSFYSSQKDTEDEFCGCLFPDPEIPGSSSSSGCSSSSTELYDLAAAHAALISRQQQILSQAIPIIPEHQLAAVAAHHQHHQQLHPSVQYQLVAAATHHNHHQPQAAQPHYSAVVPRSDVIQQPPHFALHHHLQNLVQQQQQQQAHHHHQQLVGEMALVSHTHPAAVGSTTCYEKNQQKQQQVQQIPTQPQVAHVSSNAILAAAQPFYPPPVQDSQPDRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILHRDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAVDIWSVGCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGLRAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYLEEGRLRFHSCMCSCCYTKPNMPSRLFAQDLDPRHESPFDPKWEKDMSRLSMFELREKMYQFVMDRPALYGVALCINPQSAAYKNFASSSVAQASELPPSPQAW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
619PhosphorylationAYKNFASSSVAQASE
HHHHHCCCCHHHHHH		25.9630078680
620PhosphorylationYKNFASSSVAQASEL
HHHHCCCCHHHHHHC		20.9830078680
625PhosphorylationSSSVAQASELPPSPQ
CCCHHHHHHCCCCCC		27.8230078680
630PhosphorylationQASELPPSPQAW---
HHHHCCCCCCCC---		27.9230078680
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NLK_CAEEL !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NLK_CAEEL !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NLK_CAEEL !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ODP2_CAEELdlat-1physical
14704431
YPT6_CAEELF37A4.6physical
14704431
NHR25_CAEELnhr-25genetic
16890160
WRM1_CAEELwrm-1physical
11560894
NLK_CAEELlit-1physical
10380924
WRM1_CAEELwrm-1physical
10380924
POP1_CAEELpop-1physical
10380924
WRM1_CAEELwrm-1physical
10488343
NLK_CAEELlit-1physical
10488343
POP1_CAEELpop-1physical
10488343
MYSP_CAEELunc-15genetic
17676955
DPY10_CAEELdpy-10genetic
17676955
NDUB7_CAEELD2030.4genetic
17676955
LIAS_CAEELM01F1.3genetic
17676955
HM18_CAEELceh-18genetic
17676955
RM24_CAEELmrpl-24genetic
17676955
RM03_CAEELmrps-18Cgenetic
17676955
EFTS_CAEELtsfm-1genetic
17676955
RT17_CAEELmrps-17genetic
17676955
RM23_CAEELmrpl-23genetic
17676955
EFGM_CAEELgfm-1genetic
17676955
POP1_CAEELpop-1genetic
10380924
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NLK_CAEEL

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory