MYSP_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYSP_CAEEL
• UniProt AC: P10567
• Protein Name: Paramyosin
• Gene Name: unc-15
• Organism: Caenorhabditis elegans.
• Sequence Length: 872
• Subcellular Localization: Cytoplasm, myofibril, sarcomere, A band . Localizes in punctate patterns along the myosin heavy chain myo-3 filaments in myoepithelial sheath cells.
• Protein Description: Structural component of the muscle thick filaments which is involved in assembly and organization of sarcomere myofilaments. [PubMed: 2754728]
• Protein Sequence: MSLYRSPSAALLKSPSQAAFGAPFGSMSVADLGSLTRLEDKIRLLQEDLESERELRNRVERERADLSVQVIALTDRLEDAEGTTDSQIESNRKREGELSKLRKLLEESQLESEDAMNVLRKKHQDSCLDYQDQIEQLQKKNAKIDRERQRVQHEVIELTATIDQLQKDKHTAEKAAERFEAQANELANKVEDLNKHVNDLAQQRQRLQAENNDLLKEVHDQKVQLDNLQHVKYTLAQQLEEARRRLEDAERERSQLQSQLHQVQLELDSVRTALDEESIARSDAEHKLNLANTEITQWKSKFDAEVALHHEEVEDLRKKMLQKQAEYEEQIEIMLQKISQLEKAKSRLQSEVEVLIVDLEKAQNTIALLERAREQLERQVGELKVRIDEITVELEAAQRELRAVNAELQKMKHLYEKAVEQKEALARENKKLHDELHEAKEALADANRKLHELDLENARLAGEIRELQTALKEADAQRRDAENRAQRALAELQALRIEMERRLQEKEEEMEALRKNLQFEIDRLIAALADAEARMKSEISRLKKKYQAEIAELEMTVDNLNRANIEAQKTIKKQSEQLKILQASLEDTQRQLQQVLDQYALAQRKVAALSAELEECKTALDNAIRARKQAEVDLEEANGRISDLISINNNLTSIKNKLETELSTAQADLDEVTKELHAADERANRALADAARAVEQLHEEQEHSMKIDALRKSLEEQVKQLQVQIQEAEAAALLGGKRVIAKLETRIRDLETALDEETRRHKETQNALRKKDRRIKEVQQLVDEEHKNFVMAQDTADRLTEKLNIQKRQLAESESVTMQNLQRVRRYQHELEDAEGRADQAESSLHLIRAKHRSSVVTGKSSSKIFVTEDDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLYRSPSA ------CCCCCCCCH	67.01	19530675
6	Phosphorylation	--MSLYRSPSAALLK --CCCCCCCCHHHHC	42.50	19530675
8	Phosphorylation	MSLYRSPSAALLKSP CCCCCCCCHHHHCCH	58.06	19530675
14	Phosphorylation	PSAALLKSPSQAAFG CCHHHHCCHHHHHHC	62.59	30078680
16	Phosphorylation	AALLKSPSQAAFGAP HHHHCCHHHHHHCCC	3.72	30078680
26	Phosphorylation	AFGAPFGSMSVADLG HHCCCCCCCCHHHHH	6.28	30078680
28	Phosphorylation	GAPFGSMSVADLGSL CCCCCCCCHHHHHHH	43.67	28854356
30	Phosphorylation	PFGSMSVADLGSLTR CCCCCCHHHHHHHCH	38.78	18806794
32	Phosphorylation	GSMSVADLGSLTRLE CCCCHHHHHHHCHHH	39.27	19060867
34	Phosphorylation	MSVADLGSLTRLEDK CCHHHHHHHCHHHHH	14.75	19060867
36	Phosphorylation	VADLGSLTRLEDKIR HHHHHHHCHHHHHHH	10.85	21082442
42	Phosphorylation	LTRLEDKIRLLQEDL HCHHHHHHHHHHHHH	14.30	18806794
44	Phosphorylation	RLEDKIRLLQEDLES HHHHHHHHHHHHHHH	18.82	18806794
50	Phosphorylation	RLLQEDLESERELRN HHHHHHHHHHHHHHH	33.59	18806794
52	Phosphorylation	LQEDLESERELRNRV HHHHHHHHHHHHHHH	34.60	19060867
84	Phosphorylation	LEDAEGTTDSQIESN HHHCCCCCHHHHHHH	7.38	30078680
86	Phosphorylation	DAEGTTDSQIESNRK HCCCCCHHHHHHHHH	2.31	22923814
102	Phosphorylation	EGELSKLRKLLEESQ HHHHHHHHHHHHHHH	30.85	22923814
233	Phosphorylation	DNLQHVKYTLAQQLE HHHHHHHHHHHHHHH	45.08	27067626
254	Phosphorylation	EDAERERSQLQSQLH HHHHHHHHHHHHHHH	45.28	22923814
258	Phosphorylation	RERSQLQSQLHQVQL HHHHHHHHHHHHHHH	10.82	22923814
270	Phosphorylation	VQLELDSVRTALDEE HHHHHHHHHHHCCHH	30.41	22923814
274	Phosphorylation	LDSVRTALDEESIAR HHHHHHHCCHHHHHH	43.21	22923814
542	Phosphorylation	MKSEISRLKKKYQAE HHHHHHHHHHHHHHH	10.87	18806794
542	Phosphorylation	MKSEISRLKKKYQAE HHHHHHHHHHHHHHH	10.87	18806794
543	Phosphorylation	KSEISRLKKKYQAEI HHHHHHHHHHHHHHH	9.04	18806794
543	Phosphorylation	KSEISRLKKKYQAEI HHHHHHHHHHHHHHH	9.04	18806794
544	Phosphorylation	SEISRLKKKYQAEIA HHHHHHHHHHHHHHH	3.07	18806794
544	Phosphorylation	SEISRLKKKYQAEIA HHHHHHHHHHHHHHH	3.07	18806794
813	Phosphorylation	QKRQLAESESVTMQN HHHHHHCCCCHHHHH	48.49	19530675
815	Phosphorylation	RQLAESESVTMQNLQ HHHHCCCCHHHHHHH	8.15	19530675
817	Phosphorylation	LAESESVTMQNLQRV HHCCCCHHHHHHHHH	61.20	19530675
827	Phosphorylation	NLQRVRRYQHELEDA HHHHHHHHHHHHHCC	15.21	27067626
831	Phosphorylation	VRRYQHELEDAEGRA HHHHHHHHHCCCCCH	31.97	18806794
843	Phosphorylation	GRADQAESSLHLIRA CCHHHHHHHHHHHHH	12.03	22923814
844	Phosphorylation	RADQAESSLHLIRAK CHHHHHHHHHHHHHH	23.05	22923814
854	Phosphorylation	LIRAKHRSSVVTGKS HHHHHHCCCEECCCC	24.91	28854356
855	Phosphorylation	IRAKHRSSVVTGKSS HHHHHCCCEECCCCC	47.03	28854356
859	Phosphorylation	HRSSVVTGKSSSKIF HCCCEECCCCCCCEE	41.01	22923814
860	Phosphorylation	RSSVVTGKSSSKIFV CCCEECCCCCCCEEE	16.00	22923814
861	Phosphorylation	SSVVTGKSSSKIFVT CCEECCCCCCCEEEC	5.47	30078680
862	Phosphorylation	SVVTGKSSSKIFVTE CEECCCCCCCEEECC	22.59	18806794
863	Phosphorylation	VVTGKSSSKIFVTED EECCCCCCCEEECCC	3.25	19060867
870	Phosphorylation	SKIFVTEDDY----- CCEEECCCCC-----	27.49	18806794
871	Phosphorylation	KIFVTEDDY------ CEEECCCCC------	22.14	18806794
877	Phosphorylation	DDY------------ CCC------------	40.98	18806794

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYSP_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYSP_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYSP_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of MYSP_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.