LRCC1_HUMAN - dbPTM
LRCC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LRCC1_HUMAN
UniProt AC Q9C099
Protein Name Leucine-rich repeat and coiled-coil domain-containing protein 1
Gene Name LRRCC1
Organism Homo sapiens (Human).
Sequence Length 1032
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Associates with the centrosome throughout the cell cycle and extensively accumulates during the mitotic phase.
Protein Description Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis..
Protein Sequence MEAAAAVVAAEAEVENEDGDSSCGDVCFMDKGLQSISELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLTKLCTLNLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFLTNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationVENEDGDSSCGDVCF
EECCCCCCCCCCEEE		32.8127251275
22PhosphorylationENEDGDSSCGDVCFM
ECCCCCCCCCCEEEE		27.1927251275
91PhosphorylationNTLTKLCTLNLSCNL
HHHHHHHHHCCCCCC		29.1730622161
95PhosphorylationKLCTLNLSCNLITKV
HHHHHCCCCCCCHHH		10.4130622161
117PhosphorylationNLTRLNVSYNHIDDL
HHHCCCCCCCCHHCC		21.1030622161
134UbiquitinationLIPLHGIKHKLRYID
CEECCCHHCCCEEEE		39.00-
296UbiquitinationNDLQNEIKLQKLDDQ
CHHHHHHHHHHHHHH		38.39-
311PhosphorylationILQLLNETSNSIDNV
HHHHHHHCCCCHHHH		31.9425693802
312PhosphorylationLQLLNETSNSIDNVL
HHHHHHCCCCHHHHH		23.5430622161
314PhosphorylationLLNETSNSIDNVLEK
HHHHCCCCHHHHHHC		30.9630622161
321UbiquitinationSIDNVLEKDPRPKRD
CHHHHHHCCCCCCCC		69.72-
329PhosphorylationDPRPKRDTDITSESD
CCCCCCCCCCCCCCC		33.0830622161
332PhosphorylationPKRDTDITSESDYGN
CCCCCCCCCCCCCCC		29.2924719451
333PhosphorylationKRDTDITSESDYGNR
CCCCCCCCCCCCCCH		35.1228348404
335PhosphorylationDTDITSESDYGNRKE
CCCCCCCCCCCCHHH		35.5830622161
337PhosphorylationDITSESDYGNRKECN
CCCCCCCCCCHHHCC		26.1124114839
352UbiquitinationRKVPRRSKIPYDAKT
CCCCCCCCCCCCHHH		45.98-
355PhosphorylationPRRSKIPYDAKTIQT
CCCCCCCCCHHHHHH		31.8230622161
359PhosphorylationKIPYDAKTIQTIKHH
CCCCCHHHHHHHHHC		21.7530622161
362PhosphorylationYDAKTIQTIKHHNKN
CCHHHHHHHHHCCCC		28.3030622161
372PhosphorylationHHNKNYNSFVSCNRK
HCCCCCCCCCCCCCC		19.3730622161
375PhosphorylationKNYNSFVSCNRKMKP
CCCCCCCCCCCCCCC		12.0330622161
389PhosphorylationPPYLKELYVSSSLAN
CCCHHHHHHCHHHHC		10.2030622161
391PhosphorylationYLKELYVSSSLANCP
CHHHHHHCHHHHCCC		10.7230622161
392PhosphorylationLKELYVSSSLANCPM
HHHHHHCHHHHCCCC		21.2330622161
393PhosphorylationKELYVSSSLANCPML
HHHHHCHHHHCCCCC		24.8030622161
403PhosphorylationNCPMLQESEKPKTEI
CCCCCCCCCCCCCEE		37.6530622161
405UbiquitinationPMLQESEKPKTEIIK
CCCCCCCCCCCEEEE		62.18-
408PhosphorylationQESEKPKTEIIKVDQ
CCCCCCCCEEEECCC		40.7330622161
412UbiquitinationKPKTEIIKVDQSHSE
CCCCEEEECCCCCCC		45.48-
416PhosphorylationEIIKVDQSHSEDNTY
EEEECCCCCCCCCHH		25.2330622161
418PhosphorylationIKVDQSHSEDNTYQS
EECCCCCCCCCHHHH		52.4730622161
422PhosphorylationQSHSEDNTYQSLVEQ
CCCCCCCHHHHHHHH		34.9530622161
423PhosphorylationSHSEDNTYQSLVEQL
CCCCCCHHHHHHHHH		11.4530622161
425PhosphorylationSEDNTYQSLVEQLDQ
CCCCHHHHHHHHHHH		24.7830622161
461UbiquitinationLHKHANEKEDIHSLA
HHHHCCCCCCHHHHH		61.57-
466PhosphorylationNEKEDIHSLALLTTD
CCCCCHHHHHHHCHH		18.7030622161
476UbiquitinationLLTTDRLKEIIFRER
HHCHHHHHHHHHHCC		48.00-
485PhosphorylationIIFRERNSKGQLEVM
HHHHCCCCCCHHHHH		44.3730622161
501UbiquitinationHKLQNEIKKLTVELM
HHHHHHHHHHHHHHH		35.24-
519UbiquitinationDQQEDHLKHLRTLEK
HHCHHHHHHHHHHHH		36.85-
561PhosphorylationSAADREIYLLRTSLH
CHHHHHHHHHHHHHH		8.5720736484
609UbiquitinationDFQDALAKEIAKEEK
HHHHHHHHHHHHHHH		50.97-
623UbiquitinationKKHEQMIKEYQEKID
HHHHHHHHHHHHHHH		45.05-
658UbiquitinationARRFQDVKDGFENVA
HHCHHHHHCCHHHHH		61.49-
672UbiquitinationATELAKSKHALIWAQ
HHHHHHHHHHHHHHH		31.99-
685PhosphorylationAQRKENESSSLIKDL
HHCCCCCCCHHHHHH		36.4930622161
686PhosphorylationQRKENESSSLIKDLT
HCCCCCCCHHHHHHH		24.0030622161
687PhosphorylationRKENESSSLIKDLTC
CCCCCCCHHHHHHHH		43.3124719451
690UbiquitinationNESSSLIKDLTCMVK
CCCCHHHHHHHHHHH		52.56-
693PhosphorylationSSLIKDLTCMVKEQK
CHHHHHHHHHHHHHH		14.5316674116
697UbiquitinationKDLTCMVKEQKTKLA
HHHHHHHHHHHHHHH		27.78-
707PhosphorylationKTKLAEVSKLKQETA
HHHHHHHHHHHHHHH		24.6330631047
708UbiquitinationTKLAEVSKLKQETAA
HHHHHHHHHHHHHHH		65.95-
710UbiquitinationLAEVSKLKQETAANL
HHHHHHHHHHHHHHH		50.23-
713PhosphorylationVSKLKQETAANLQNQ
HHHHHHHHHHHHHHH		28.6918452278
735PhosphorylationIEDDKQKSIQIELLK
ECCCCCCCEEEEEHH		19.7530622161
747 (in isoform 2)Ubiquitination-44.1121890473
757PhosphorylationSELAAKESLIFGLRT
HHHHHHCHHHHCCCC		26.5121712546
767UbiquitinationFGLRTERKVWGHELA
HCCCCCCHHHHHHHH		35.7921890473
767 (in isoform 1)Ubiquitination-35.7921890473
778PhosphorylationHELAQQGSSLAQNRG
HHHHHHHCHHHHHHC		20.1730622161
779PhosphorylationELAQQGSSLAQNRGK
HHHHHHCHHHHHHCH		34.2530622161
786UbiquitinationSLAQNRGKLEAQIES
HHHHHHCHHHHHHHH		39.66-
803UbiquitinationRENECLRKTNESDSD
HHHHHHHHCCCCHHH		42.63-
836UbiquitinationLKDCLQEKDEHIKRL
HHHHHHHHHHHHHHH		56.29-
846UbiquitinationHIKRLQEKITEIEKC
HHHHHHHHHHHHHHH		41.80-
852UbiquitinationEKITEIEKCTQEQLD
HHHHHHHHHCHHHHH		48.52-
862PhosphorylationQEQLDEKSSQLDEVL
HHHHHHHHHHHHHHH		22.6730622161
863PhosphorylationEQLDEKSSQLDEVLE
HHHHHHHHHHHHHHH		45.9230622161
871UbiquitinationQLDEVLEKLERHNER
HHHHHHHHHHHHHHH		52.03-
898UbiquitinationVELEEIRKAYSTLNR
CCHHHHHHHHHHHHH		58.29-
901PhosphorylationEEIRKAYSTLNRKWH
HHHHHHHHHHHHHCC		31.1430622161
902PhosphorylationEIRKAYSTLNRKWHD
HHHHHHHHHHHHCCC		18.5130622161
906AcetylationAYSTLNRKWHDKGEL
HHHHHHHHCCCCCHH		48.0519817455
910UbiquitinationLNRKWHDKGELLCHL
HHHHCCCCCHHHHHH		41.20-
942PhosphorylationLKAERDKSIELQKNA
HHHHHHHHHHHHHHH		26.1130622161
947UbiquitinationDKSIELQKNAMEKLH
HHHHHHHHHHHHHHH		60.34-
952UbiquitinationLQKNAMEKLHSMDDA
HHHHHHHHHHCCCHH		38.11-
955PhosphorylationNAMEKLHSMDDAFKR
HHHHHHHCCCHHHHH		34.0530622161
961MethylationHSMDDAFKRQVDAIV
HCCCHHHHHHHHHHH		43.57115972639
982UbiquitinationIAQLANEKQKCIDSA
HHHHHHHHHHHHHHH		55.66-
988PhosphorylationEKQKCIDSANLKVHQ
HHHHHHHHHCHHHHH		10.11-
988O-linked_GlycosylationEKQKCIDSANLKVHQ
HHHHHHHHHCHHHHH		10.1130379171
998UbiquitinationLKVHQIEKEMRELLE
HHHHHHHHHHHHHHH		59.44-
1007PhosphorylationMRELLEETCKNKKTM
HHHHHHHHHCCCCHH		21.2926074081
1013PhosphorylationETCKNKKTMEAKIKQ
HHHCCCCHHHHHHHH		23.1226074081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LRCC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LRCC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LRCC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MYH7B_HUMANMYH7Bphysical
28514442
ACTN3_HUMANACTN3physical
28514442
PCM1_HUMANPCM1physical
28514442
CP131_HUMANCEP131physical
28514442
AT1A4_HUMANATP1A4physical
28514442
AT2A3_HUMANATP2A3physical
28514442
POTEE_HUMANPOTEEphysical
28514442
AT2A1_HUMANATP2A1physical
28514442
PIBF1_HUMANPIBF1physical
28514442
TBA3C_HUMANTUBA3Cphysical
28514442
KIF7_HUMANKIF7physical
28514442
MIB1_HUMANMIB1physical
28514442
STRP1_HUMANSTRIP1physical
28514442
STRN_HUMANSTRNphysical
28514442
FBX28_HUMANFBXO28physical
28514442
MED4_HUMANMED4physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LRCC1_HUMAN

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Related Literatures of Post-Translational Modification

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