| UniProt ID | GLRA2_HUMAN | |
|---|---|---|
| UniProt AC | P23416 | |
| Protein Name | Glycine receptor subunit alpha-2 | |
| Gene Name | GLRA2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 452 | |
| Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein . Cell junction, synapse . Cell membrane Multi-pass membrane protein . Cell projection . |
|
| Protein Description | Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. [PubMed: 2155780] | |
| Protein Sequence | MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 39 | Phosphorylation | SRSGKQPSQTLSPSD CCCCCCCCCCCCHHH | 33.05 | 24719451 | |
| 43 | Phosphorylation | KQPSQTLSPSDFLDK CCCCCCCCHHHHHHH | 26.24 | 24719451 | |
| 45 | Phosphorylation | PSQTLSPSDFLDKLM CCCCCCHHHHHHHHC | 37.30 | 24719451 | |
| 58 | Phosphorylation | LMGRTSGYDARIRPN HCCCCCCCCCCCCCC | 13.24 | 19664994 | |
| 72 | N-linked_Glycosylation | NFKGPPVNVTCNIFI CCCCCCCEEEEEEEE | 29.20 | UniProtKB CARBOHYD | |
| 103 | N-linked_Glycosylation | IFLRQQWNDSRLAYS EEEECCCCCCCCCCC | 32.80 | UniProtKB CARBOHYD | |
| 163 | Phosphorylation | KNGKVLYSIRLTLTL CCCEEEEEEEEEEEE | 9.32 | 24719451 | |
| 167 | Phosphorylation | VLYSIRLTLTLSCPM EEEEEEEEEEEECCC | 14.09 | - | |
| 233 | Phosphorylation | EKELGYCTKHYNTGK HHHHCCEEEECCCCC | 16.63 | 30576142 | |
| 238 | Phosphorylation | YCTKHYNTGKFTCIE CEEEECCCCCEEEEE | 34.28 | 30576142 | |
| 242 | Phosphorylation | HYNTGKFTCIEVKFH ECCCCCEEEEEEEEH | 18.96 | 24719451 | |
| 313 | Phosphorylation | ASLPKVSYVKAIDIW CCCCCCCHHHHHHHH | 14.68 | - | |
| 368 | Phosphorylation | EEDVTRESRFNFSGY CCCCCHHHHCCCCCC | 38.59 | - | |
| 422 | Phosphorylation | AKRIDTISRAAFPLA HHHHCHHHHHHHHHH | 20.26 | 23532336 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GLRA2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GLRA2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GLRA2_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
