GEMI7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GEMI7_HUMAN
• UniProt AC: Q9H840
• Protein Name: Gem-associated protein 7
• Gene Name: GEMIN7
• Organism: Homo sapiens (Human).
• Sequence Length: 131
• Subcellular Localization: Nucleus, nucleoplasm . Nucleus, gem . Cytoplasm . Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
• Protein Description: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus..
• Protein Sequence: MQTPVNIPVPVLRLPRGPDGFSRGFAPDGRRAPLRPEVPEIQECPIAQESLESQEQRARAALRERYLRSLLAMVGHQVSFTLHEGVRVAAHFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYTFKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MQTPVNIP -------CCCCCCCC	10.12	22223895
3	Phosphorylation	-----MQTPVNIPVP -----CCCCCCCCCC	28.10	29255136
16	Methylation	VPVLRLPRGPDGFSR CCEEECCCCCCCCCC	74.08	-
23	Methylation	RGPDGFSRGFAPDGR CCCCCCCCCCCCCCC	41.82	-
44	Glutathionylation	EVPEIQECPIAQESL CCCCHHCCCCCHHHH	1.37	22555962
50	Phosphorylation	ECPIAQESLESQEQR CCCCCHHHHHHHHHH	25.92	-
53	Phosphorylation	IAQESLESQEQRARA CCHHHHHHHHHHHHH	44.29	-
128	Phosphorylation	CSDIISYTFKP---- CHHHHEEECCC----	20.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GEMI7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GEMI7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GEMI7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GEMI6_HUMAN	GEMIN6	physical	16189514
KAT5_HUMAN	KAT5	physical	16169070
GEMI6_HUMAN	GEMIN6	physical	12065586
SMN_HUMAN	SMN1	physical	12065586
FEZ1_HUMAN	FEZ1	physical	21900206
CE126_HUMAN	KIAA1377	physical	21900206
TBA1A_HUMAN	TUBA1A	physical	21900206
ADDA_HUMAN	ADD1	physical	21900206
SHC1_HUMAN	SHC1	physical	21900206
EDRF1_HUMAN	EDRF1	physical	21900206
TAOK1_HUMAN	TAOK1	physical	21900206
RLA1_HUMAN	RPLP1	physical	21900206
GEMI6_HUMAN	GEMIN6	physical	25416956
GEMI6_HUMAN	GEMIN6	physical	21516116
KC1D_HUMAN	CSNK1D	physical	26496610
EZH2_HUMAN	EZH2	physical	26496610
ITB4_HUMAN	ITGB4	physical	26496610
SMN_HUMAN	SMN1	physical	26496610
RU17_HUMAN	SNRNP70	physical	26496610
SMD1_HUMAN	SNRPD1	physical	26496610
GEMI2_HUMAN	GEMIN2	physical	26496610
FARP1_HUMAN	FARP1	physical	26496610
RCL1_HUMAN	RCL1	physical	26496610
YMEL1_HUMAN	YME1L1	physical	26496610
STRAP_HUMAN	STRAP	physical	26496610
DDX20_HUMAN	DDX20	physical	26496610
GEMI5_HUMAN	GEMIN5	physical	26496610
GEMI4_HUMAN	GEMIN4	physical	26496610
GEMI8_HUMAN	GEMIN8	physical	26496610
AKIP_HUMAN	AURKAIP1	physical	26496610
TPC_HUMAN	SLC25A19	physical	26496610
KLC2_HUMAN	KLC2	physical	26496610
GEMI6_HUMAN	GEMIN6	physical	26496610
LSM11_HUMAN	LSM11	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.