FOXD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOXD3_HUMAN
• UniProt AC: Q9UJU5
• Protein Name: Forkhead box protein D3
• Gene Name: FOXD3
• Organism: Homo sapiens (Human).
• Sequence Length: 478
• Subcellular Localization: Nucleus .
• Protein Description: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis..
• Protein Sequence: MTLSGGGSASDMSGQTVLTAEDVDIDVVGEGDDGLEEKDSDAGCDSPAGPPELRLDEADEVPPAAPHHGQPQPPHQQPLTLPKEAAGAGAGPGGDVGAPEADGCKGGVGGEEGGASGGGPGAGSGSAGGLAPSKPKNSLVKPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRHQQEHLREQTALMMQSFGAYSLAAAAGAAGPYGRPYGLHPAAAAGAYSHPAAAAAAAAAAALQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFGSQLGPGLQLQLNSLGAAAAAAGTAGAAGTTASLIKSEPSARPSFSIENIIGGGPAAPGGSAVGAGVAGGTGGSGGGSTAQSFLRPPGTVQSAALMATHQPLSLSRTTATIAPILSVPLSGQFLQPAASAAAAAAAAAQAKWPAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	DGLEEKDSDAGCDSP CCCCCCCCCCCCCCC	40.19	25850435
46	Phosphorylation	DSDAGCDSPAGPPEL CCCCCCCCCCCCCCC	22.26	29255136
146	Phosphorylation	LVKPPYSYIALITMA CCCCCHHHHHHHHHH	5.60	-
213	N-linked_Glycosylation	PGNPGKGNYWTLDPQ CCCCCCCCCCCCCCC	32.43	-
213	N-linked_Glycosylation	PGNPGKGNYWTLDPQ CCCCCCCCCCCCCCC	32.43	19349973
214	Phosphorylation	GNPGKGNYWTLDPQS CCCCCCCCCCCCCCC	14.40	-
229	Phosphorylation	EDMFDNGSFLRRRKR HHHCCCCHHHHHHHH	27.62	-
335	Phosphorylation	RKAAAFGSQLGPGLQ HHHHHHHHCCCCCHH	18.77	22210691
347	Phosphorylation	GLQLQLNSLGAAAAA CHHHHHHHHHHHHHH	36.45	22210691
366	Phosphorylation	GAAGTTASLIKSEPS CCCCHHHHHHHCCCC	28.65	24719451
436	Phosphorylation	MATHQPLSLSRTTAT HHHCCCCCCCCCCCC	30.86	24719451
438	Phosphorylation	THQPLSLSRTTATIA HCCCCCCCCCCCCCC	24.97	17081983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FOXD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOXD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOXD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PO5F1_HUMAN	POU5F1	physical	11891324
FOXD1_HUMAN	FOXD1	physical	25609649
HXD13_HUMAN	HOXD13	physical	25609649
2ABD_HUMAN	PPP2R2D	physical	25609649
CUX1_HUMAN	CUX1	physical	25609649
CASP_HUMAN	CUX1	physical	25609649
TOP2A_HUMAN	TOP2A	physical	25609649
TOP2B_HUMAN	TOP2B	physical	25609649
DNLI3_HUMAN	LIG3	physical	25609649
VRK3_HUMAN	VRK3	physical	25609649
UBIP1_HUMAN	UBP1	physical	25609649
ML12B_HUMAN	MYL12B	physical	25609649
SATB1_HUMAN	SATB1	physical	25609649
XRCC1_HUMAN	XRCC1	physical	25609649
NC2A_HUMAN	DRAP1	physical	25609649
HXB9_HUMAN	HOXB9	physical	25609649
MYL9_HUMAN	MYL9	physical	25609649
SATB2_HUMAN	SATB2	physical	25609649

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 607836: Autoimmune disease 1 (AIS1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.