FOXD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOXD1_HUMAN
• UniProt AC: Q16676
• Protein Name: Forkhead box protein D1
• Gene Name: FOXD1
• Organism: Homo sapiens (Human).
• Sequence Length: 465
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes. [PubMed: 27805902]
• Protein Sequence: MTLSTEMSDASGLAEETDIDVVGEGEDEEDEEEEDDDEGGGGGPRLAVPAQRRRRRRSYAGEDELEDLEEEEDDDDILLAPPAGGSPAPPGPAPAAGAGAGGGGGGGGAGGGGSAGSGAKNPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQPLLPPNAAAAESLLLRGAGAAGGAGDPAAAAALFPPAPPPPPHAYGYGPYGCGYGLQLPPYAPPSALFAAAAAAAAAAAFHPHSPPPPPPPHGAAAELARTAFGYRPHPLGAALPGPLPASAAKAGGPGASALARSPFSIESIIGGSLGPAAAAAAAAQAAAAAQASPSPSPVAAPPAPGSSGGGCAAQAAVGPAAALTRSLVAAAAAAASSVSSSAALGTLHQGTALSSVENFTARISNC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
128	Phosphorylation	NPLVKPPYSYIALIT CCCCCCCHHHHHHHH	23.72	23401153
129	Phosphorylation	PLVKPPYSYIALITM CCCCCCHHHHHHHHH	18.81	23401153
130	Phosphorylation	LVKPPYSYIALITMA CCCCCHHHHHHHHHH	5.60	23401153
135	Phosphorylation	YSYIALITMAILQSP HHHHHHHHHHHHHCC	11.03	23401153
141	Phosphorylation	ITMAILQSPKKRLTL HHHHHHHCCCCCCCH	34.93	23401153
147	Phosphorylation	QSPKKRLTLSEICEF HCCCCCCCHHHHHHH	32.07	-
156	Phosphorylation	SEICEFISGRFPYYR HHHHHHHHCCCHHHH	29.27	24719451
236	Phosphorylation	PNAAAAESLLLRGAG CCHHHHHHHHHHCCC	21.42	30257219
345	Phosphorylation	LPGPLPASAAKAGGP CCCCCCHHHHHHCCC	27.16	-
395	Phosphorylation	AQASPSPSPVAAPPA HHCCCCCCCCCCCCC	36.02	-
423	Phosphorylation	VGPAAALTRSLVAAA HCHHHHHHHHHHHHH	17.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FOXD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOXD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOXD1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FOXD1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.