EXOC7_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EXOC7_DROME
• UniProt AC: Q9VSJ8
• Protein Name: Exocyst complex component 7
• Gene Name: Exo70 {ECO:0000312|FlyBase:FBgn0266667}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 693
• Protein Description: Required for exocytosis. Thought to function in intracellular vesicle targeting and docking before SNARE complex formation..
• Protein Sequence: MNNLDSSLQAHNKLEKEATNLALLKDRVDKYHDLSTQMSSILTIFEKRLGNLEQTILPVYQETEQLQKRQQNLEATLNCLESVLSHYDVSQEVCQLIHQGPVEGNISVFLDALAKLRDANDYFRHNNSQSVELENVTSLFNTGCEGLSQHYSMLLKKHSAPLKPVELLDLIYIEDDSSDEYTSFRQLSQTTREELYTISHWLEQNLREYTNIYATERGEVVLRSLQLLKDHQKSNSWGHEALRPRHSGRQTEPKKTTSARLQQIFEKKANKLYLRATQTIEQSTGFSIKKASSHSDHLTSEDLMDGDQELDKYLVMLLGLQRLLNWERAIMIDIIPQSKHNEVFATLAYNAIDLVVKDAEAITQRILRCISRKEWTSALGIFSALKRVILLQPDIDRTYDPAQREQLKKVLKKLQHTGAKALEHFLDVVKGESSTNIVGQSNVPKDATVHELTSNTIWFIEHLYDHFDVIGSILAQDVLYSTQLDTILMKKALPVEERNKALLAIYIKKALAELNLSIMNKCEQYNDQATKHLFRLNNIHYILKSLQRSNLIDLVTLAEPECEHSYMEMIRELKASYQKTWSKMLVGIYSLDELPKPVAGKVKDKDRSVLKERFSNFNKDFEEACKIQRGISIPDVILREGIKRDNVEHILPIYNRFYEIYSGVHFSKNPDKYVKYRQHEINAMLSKLFDDSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
234	Phosphorylation	LLKDHQKSNSWGHEA HHHHHHHCCCCCCCC	29.53	19429919
236	Phosphorylation	KDHQKSNSWGHEALR HHHHHCCCCCCCCCC	41.34	19429919
277	Phosphorylation	NKLYLRATQTIEQST CHHHHHHHCHHHHHH	21.58	22817900
287	Phosphorylation	IEQSTGFSIKKASSH HHHHHCCCEEECCCC	34.54	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EXOC7_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EXOC7_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EXOC7_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTN_DROME	Actn	physical	15710747
CCDCX_DROME	CG32809	physical	15710747
DMDD_DROME	Dys	physical	15710747
DMDE_DROME	Dys	physical	15710747
DMDB_DROME	Dys	physical	15710747
DMDA_DROME	Dys	physical	15710747
SPTCA_DROME	alpha-Spec	physical	15710747
WASH1_DROME	wash	physical	15710747
KINH_DROME	Khc	physical	15710747
PYR1_DROME	r	physical	15710747
BTKL_DROME	Btk29A	physical	15710747
VPS51_DROME	CG15087	physical	15710747
NUP54_DROME	Nup54	physical	15710747
CCD22_DROME	CG9951	physical	15710747
HR4_DROME	Hr4	physical	15710747
TPR_DROME	Mtor	physical	15710747
MYSP1_DROME	Prm	physical	15710747
MYSP2_DROME	Prm	physical	15710747
TPM1_DROME	Tm1	physical	15710747
TPM4_DROME	Tm1	physical	15710747
TPM2_DROME	Tm2	physical	15710747
VINC_DROME	Vinc	physical	15710747
ARM_DROME	arm	physical	16224820

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, AND MASSSPECTROMETRY.
PubMed: 18327897