dbPTM

WASH1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WASH1_DROME
UniProt AC	Q7JW27
Protein Name	WASH complex subunit 1 {ECO:0000250\|UniProtKB:A8K0Z3}
Gene Name	wash {ECO:0000312\|FlyBase:FBgn0033692}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	499
Subcellular Localization
Protein Description	Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization. [PubMed: 19633175 Participates in both linear- and branched-actin networks]
Protein Sequence	MEESPYLHSPYQVAIIATDLHHEDTIIQAAQSLDCLHKTINSIFERIDARLARNGSKVEDINNRVKRAQAKIDALVGSKRAIQIFAPARFPASDVLAPLPATFPQVAANPLMEQQVDQLPQGTYSSHSAADQKPDDADIFFHVRGDREQESPLVAERKITNRTAGLGILPAGGVRSVPSLMRFNTNEFAYGEDLNAWKRSLPPQNARRVASQSTQLTGEKQLAPAPHSLAHGTTKLATPAGDLRYNPAALAAPAIDVPLDLPDLPGIANDLQYEPVEEQTPIAPSQQFGDLPELPDLGLEEQDIIVQAIAAQTHIPGPVRRKSVGQCPSPVTAAPPPPPPPPPPPPPPPPAQTSAIPSPPPFPTKGAVKPLSPSLATPLNMPQPPPATEDPRSELMAAIRNAGGVHGGRLRSPAAAPLDVVDNSRSKAGGAVTGDLMADLHNKLMLRRKGISGSQNPVEATAGNPLMQQLSRVIPPPVQPRKGSKSSDEHSEDDEDGWN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
372	Phosphorylation	KGAVKPLSPSLATPL CCCCCCCCHHHCCCC	22.44	21082442
471	Phosphorylation	NPLMQQLSRVIPPPV CHHHHHHHCCCCCCC	21.84	21082442
491	Phosphorylation	SKSSDEHSEDDEDGW CCCCCCCCCCCCCCC	40.45	18327897

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WASH1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WASH1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WASH1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JNK_DROME	bsk	physical	14605208
CAPU_DROME	capu	physical	19633175
LAM0_DROME	Lam	physical	25754639
WASH1_DROME	wash	physical	19633175
VATB_DROME	Vha55	physical	27884932
SPIR_DROME	spir	physical	19633175

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WASH1_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-491, AND MASSSPECTROMETRY.	18327897 [Abstract]