PYR1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PYR1_DROME
• UniProt AC: P05990
• Protein Name: CAD protein
• Gene Name: r
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2224
• Subcellular Localization: Cytoplasm.
• Protein Description: This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)..
• Protein Sequence: MASTDCYLALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPLIGNYGVPAPDEDEHGLPLHFEWMKGVVQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQDIDTRALTKKLREQGSMLGKIVYEKPPVEGLPKSSFVDPNVRNLAKECSVKERQVYGNPNGKGPRIAILDCGLKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNGPGNPESCDQIVQQVRKVIEEGQKPVFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQNHGYAVDLEQLPDGWSELFVNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFMESIQQKDLTIPQLIEQRLRPTTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQAIKAMRESNIQTVLINPNIATVQTSKGMADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGVQLERAGVFSKYNVRILGTPIQSIIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYPVMARAAFSLGGLGSGFANNEEELQSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCITVCNMENFDPLGIHTGESIVVAPSQTLSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKHIGSSMKSVGEVMAIGRNFEEAFQKALRMVDSDVLGFDPDVVPLNKEQLAEQLSEPTDRRPFVIAAALQLGMSLRELHQLTNIDYWFLEKLERIILLQSLLTRNGSRTDAALLLKAKRFGFSDKQIAKYIKSTELAVRHQRQEFGIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDVDFPGGHTIVVGSGVYRIGSSVEFDWCAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGIILSMGGQLPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIEFCEEVGYPCLVRPSYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVASDGRILCMAVSEHVENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQLIAKNNELKVIECNVRVSRSFPFVSKTLDHDFVATATRAIVGLDVEPLDVLHGVGKVGVKVPQFSFSRLAGADVQLGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSIGSFKHKMELLPSIRDLAKMGYKLYASMGTGDFYAEHGVNVESVQWTFDKTTPDDINGELRHLAEFLANKQFDLVINLPMSGGGARRVSSFMTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMRMNGGKPPMKTHTDCMTSRRIVKLPGFIDVHVHLREPGATHKEDFASGTAAALAGGVTLVCAMPNTNPSIVDRETFTQFQELAKAGARCDYALYVGASDDNWAQVNELASHACGLKMYLNDTFGTLKLSDMTSWQRHLSHWPKRSPIVCHAERQSTAAVIMLAHLLDRSVHICHVARKEEIQLIRSAKEKGVKVTCEVCPHHLFLSTKDVERLGHGMSEVRPLLCSPEDQEALWENIDYIDVFATDHAPHTLAEKRSERPPPGFPGVETILPLLLQAVHEGRLTMEDIKRKFHRNPKIIFNLPDQAQTYVEVDLDEEWTITGNEMKSKSGWTPFEGTKVKGRVHRVVLRGEVAFVDGQVLVQPGFGQNVRPKQSPLASEASQDLLPSDNDANDTFTRLLTSEGPGGGVHGISTKVHFVDGANFLRPNSPSPRIRLDSASNTTLREYLQRTTNSNPVAHSLMGKHILAVDMFNKDHLNDIFNLAQLLKLRGTKDRPVDELLPGKIMASVFYEVSTRTQCSFAAAMLRLGGRVISMDNITSSVKKGESLEDSIKVVSSYADVVVLRHPSPGAVARAATFSRKPLINAGDGVGEHPTQALLDIFTIREEFGTVNGLTITMVGDLKNGRTVHSLARLLTLYNVNLQYVAPNSLQMPDEVVQFVHQRGVKQLFARDLKNVLPDTDVLYMTRIQRERFDNVEDYEKCCGHLVLTPEHMMRAKKRSIVLHPLPRLNEISREIDSDPRAAYFRQAEYGMYIRMALLAMVVGGRNTAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
217	Phosphorylation	CLLQRGASVTLLPWS HHHHCCCEEEEEECH	20.61	21082442
1421	Phosphorylation	GGGARRVSSFMTHGY CCCHHHHHHHHCCCC	18.95	21082442
1571	Carboxylation	ASHACGLKMYLNDTF HHHHHCCEEHHHCCC	15.69	-
1744	Acetylation	RLTMEDIKRKFHRNP CCCHHHHHHHHHCCC	62.95	21791702
1829	Phosphorylation	QNVRPKQSPLASEAS CCCCCCCCCCCCHHH	28.18	19429919
1833	Phosphorylation	PKQSPLASEASQDLL CCCCCCCCHHHHCCC	41.18	19429919
1836	Phosphorylation	SPLASEASQDLLPSD CCCCCHHHHCCCCCC	21.85	19429919
1842	Phosphorylation	ASQDLLPSDNDANDT HHHCCCCCCCCCCHH	49.36	19429919
1883	Phosphorylation	ANFLRPNSPSPRIRL CCCCCCCCCCCCEEE	29.45	19429919
1885	Phosphorylation	FLRPNSPSPRIRLDS CCCCCCCCCCEEECC	26.99	19429919
1892	Phosphorylation	SPRIRLDSASNTTLR CCCEEECCCCCHHHH	37.88	21082442
1894	Phosphorylation	RIRLDSASNTTLREY CEEECCCCCHHHHHH	38.37	10080891
1896	Phosphorylation	RLDSASNTTLREYLQ EECCCCCHHHHHHHH	25.39	29892262
2010	Phosphorylation	EDSIKVVSSYADVVV HHHHHHHHCCCCEEE	22.18	22817900
2011	Phosphorylation	DSIKVVSSYADVVVL HHHHHHHCCCCEEEE	16.84	22817900
2174	Phosphorylation	MMRAKKRSIVLHPLP HHHHHHCEEEEECCC	26.40	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PYR1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PYR1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PYR1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COPB_DROME	betaCOP	physical	22036573
SYEP_DROME	Aats-glupro	physical	22036573
IDH3A_DROME	l(1)G0156	physical	22036573
NFS1_DROME	CG12264	physical	22036573
CCD1P_DROME	Cyp12d1-p	physical	22036573
TCPG_DROME	Cctgamma	physical	22036573
2AAA_DROME	Pp2A-29B	physical	22036573
CARM1_DROME	Art4	physical	22036573
ACADM_DROME	CG12262	physical	22036573
MESD_DROME	boca	physical	22036573
SUHW_DROME	su(Hw)	genetic	1281517
ER_DROME	e(r)	genetic	7896098
ER_DROME	e(r)	genetic	16849599
ER_DROME	e(r)	genetic	18820471
SRYC_DROME	wdn	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1883; SER-1885; SER-1892AND SER-1894, AND MASS SPECTROMETRY.
PubMed: 18327897