dbPTM

EXOC2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EXOC2_DROME
UniProt AC	Q9VQQ9
Protein Name	Exocyst complex component 2
Gene Name	Sec5 {ECO:0000312\|FlyBase:FBgn0266670}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	894
Subcellular Localization
Protein Description	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane..
Protein Sequence	MAPQPVVTGLSPKEGPPGTRVIIRGEFLGTRVQDLIGLKICGSDCLLSAEWKSPNKIIARTGPAKGKGDIIVTTLSGGVGTSTVQFRAYHETIGPLKESAVWIEESPSQNFAWGRRTLAQSGLTQEDPLGLSIEGNEQKIPEDLRDLFPEACGDLSQEHFSPAWFLLENHLATSFEDLKAGLSYLKRKVESQKEGQLSFLKSNAGSVIDQLDTLMNIRDKLQEDVKLHGNETLNILETSIENSISESQKIFTDVLVRKEKADSTRSVLFALSRHKFLFCLPNSVDRRAKAGEYDIVVNDYSRAKNLFGKTEIPIFRKVLEEVDHRILSIRKQLHEKVVKMPQSVEQQKKLIKALISLELQQSGTPIGDKLRNIDPAWDAIEARAKYLEWTFRQTFDQHTSKDSGAQEKAKNRDSSQAPNRVNFCEELCDIAASQLPDLWRLGQLYFTGELRGPHDPKPGDFKRMVLNAIEKFCVYLRLAILIATDQRALRQSSGLAWPIGSASATHQFLPWIPQCLRFTRIAYATLISLDLPSEALDIIQKLIDEVRLFCFSIIFKRATDRCKKLGSQETWELGVEEYPGATLLPAALETLLIETLDEVQSVCMQRETREGNLLEPQSDGQREVTQRLQEFLSAFSAVIEELAFHSHDEETPTHNVSQLLGFPNAQQPDSVAGSGGAAAVTWEQRMLCCLANYAYCNKIFFPRLGDIFVRYGYPLPTLAIETARYTVNQLFTNLLEEYVEHKGDPLVGTIEPSMYLGRFQWDHEMEIGQLRPYAHECCDNLVGVYSEIYSISPALLRPILESIVQTISEELARLMSCVQRFSFTGAIQAHVDIRLLRDSLEGYVNETAKNYFMEALEAINPPLSGEQKRKADEILERVKRNMRLQLLCFSVKDP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
364	Phosphorylation	LELQQSGTPIGDKLR HHHHHCCCCCHHHHC	19.58	27794539
414	Phosphorylation	EKAKNRDSSQAPNRV HHHHCCCCCCCCCHH	22.55	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EXOC2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EXOC2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EXOC2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL371_DROME	RpL37a	physical	14605208
1433E_DROME	14-3-3epsilon	physical	15710747
THR_DROME	thr	physical	15710747
1433Z_DROME	14-3-3zeta	physical	15710747
SPTCB_DROME	beta-Spec	physical	15710747
GSTCD_DROME	CG10428	physical	15710747
SMG1_DROME	nonC	physical	15710747
NIPB_DROME	Nipped-B	physical	15710747
ZFY26_DROME	CG5270	physical	15710747
CCNB_DROME	CycB	physical	15710747
FOJO_DROME	fj	physical	15710747
HIW_DROME	hiw	physical	15710747
HTH_DROME	hth	physical	15710747
PICAL_DROME	lap	physical	15710747
KDM5_DROME	lid	physical	15710747
PGK_DROME	Pgk	physical	15710747
SRYA_DROME	Sry-alpha	physical	15710747
MED21_DROME	MED21	physical	15710747
MED4_DROME	MED4	physical	15710747
EXOC3_DROME	Sec6	physical	15897260

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EXOC2_DROME

Related Literatures of Post-Translational Modification