dbPTM

THR_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	THR_DROME
UniProt AC	P42286
Protein Name	Protein three rows
Gene Name	thr
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1379
Subcellular Localization	Cytoplasm . Cytoplasmic during interphase and distributed throughout the cell during early mitosis.
Protein Description	Required specifically for chromosome disjunction during all mitoses; maternally provided protein is sufficient until mitosis 14 then zygotic protein is required. Involved in formation and/or maintenance of epithelial structures: bud extension during Malpighian tubule development, and foregut and hindgut morphogenesis..
Protein Sequence	MSTDIATQLKGSRSDVEKVRKTVEAKFRELSGDGLPLRYEVNVLRHICLALKDNLHQNSDLYCDIMGIMLPRVVPCEEKPSLWEAHLSSLRYIHHGLFHQRSIEACQKLYNLIRQQPCRLQEESDYKIYLDIHLTHFNGFHVLLQKQKLPLEATSQLCYALESLGDLFAAMTQRQISLCATLLVQLNESLFGKRSRSFFKSLSFLPSESLAKMFNALLMLLASSTSSNLANLFPECLSLTLALVQIDMFSPQSNQQMSLQLLRMSKELFRQESNLCYALQLMYYYIKLIFVREPTGDFKRTYIDLSSKFQHFFEHKVASHAKEQWLADFLVAIQLLQVLIHQSNSKLQSPFQIFWQQFDGESSPEIYTAHFQLLQTCASLAVNITRSPLGCSCSHEACKSVRRHCILAYGLCALDAYINWKPAAEQRANVSPHKPLLGVVKYSMDVAKTMKCLGPTSVEIIKLVRQLTYVADQVTCPEQMSVLLPLLEPLQKLRPLVADQDMSSLLRRLFKASSHCGDSNIACRIQASYLASITNPARLRSQVCLYYHNLGKKGTEIKRCVYEWHESTPLPFPLTPDQKKQLYDTDFFALLHYLRSPSTAHMESLIRCRTSDYHLVLLARQMRKDDSISKKCIEVHDKLRQQRSLSRMDNLCLGHASVGLLLDALEAQKTKVSTKEITENMFEELLLSKNLWQMNIQREQRLVNYASEAISAFSNFFDRADQEPLSANETSIDWEALIDDAIATANALSSMGYQSEEDDAWLLLLRMGRLLEDRFTYLRALNHFLSQNEVSSRLNLKLGEEVEVAEELLDDLWPQLKNGKFFKRQQTTVMLCFCHLASYYARMECYSHAQLLLLHVEQLREEFPERQGKSDIVLLTLQTVRFRIGYQQRKPTNCRLPTPLRQLDILLDNVRSFCNLSSLDGGSLQLLLSTLVRESTECSANRLSERLSFSNIALHLVLQSGLALRAIEVFLAWLWTNLQMESFDKAQSKLRLIEHCLGIKQLNPTSRPEKEAIKDVAISDLASNMHLLQLVEPIRKQQLLNMASPNLLKMRPHSPNPQLDLDRYITLDVAPANLRENSQLQCLYFVTGCLHARLRFLQRNSEQLEEFYGRAHNWMQEKPPMSSALYPMLHAQQLYHLNYLRFARKHVEAISTAQLGLKMRSRAVDINFEYNFLAQLKTAQLELKPVGQDKPQVKILRRALVFNHSPEDKKRTATGSVSAVKNTASKVKQSAKKAPRFRIYEELELRPPSATSCSSSGGSGTENTPPSDHVDLNACQAIEISDDDDSPLVSTKKTQPKSREKAKPKATSKACKVLTLDNSLEIVETPTITTSTRSTRARLRQPVETPKTATLSSKRTRRQVLEAQAPETESISTRTRHRH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
1205	Phosphorylation	RALVFNHSPEDKKRT HHHHHCCCHHHHCCC	30.96	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of THR_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of THR_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of THR_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of THR_DROME

Related Literatures of Post-Translational Modification