CYAA_SCHPO - dbPTM
CYAA_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CYAA_SCHPO
UniProt AC P14605
Protein Name Adenylate cyclase
Gene Name cyr1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1692
Subcellular Localization Cytoplasm .
Protein Description Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP..
Protein Sequence MDQSKRLLKSAVPNPPEHFKTGISWLDDLDEKDDDSATSVNYDIPEITEANLCNDSHEALSPCTQPVGNSGRPVEAFKTYPSTPAVPSKSVLFHFYEPDENFSLSDTGRTKSDTALAARESSEKSEVPRDTRSAGIKPYKENNSSNCAISKEAGLRRLIDKDRESFDKNLNQSFTNLTFPEPISDDSDSVEFQRDSLNNNWPASLEGSIHELPRNSDDDGIPASAAHILDLDYHRDSYDSPWKKFLPYPSILSDDSWKAPESWGTSLPTEAIPKQVFTTRFFARPSLGNRKKEFFLRVYRDDRTSVSFICPIGIQTHEVIKLLARLFFLPSSANFYLLLIQFNTERILLPHEQPCIIFERLLSLFGCKVTSDEEINEEDNYSVARLVFTTMDIGADVLRKFSEKKITANLDISRSNLEVIPVKIYPYAHELISLNVSHNLSLDLPLDFMERCVKLKRLDISNNLRSPRGKPITALRQLEVLNMSRNDIYELDPLIFSGLSRNSLKELNIANNKLFFLPHSTRYLVNLTYLDLSYNNFVTFPLIITELSQLETLNFSHNLLSQISSKIGSLVKLKHLYLQFNDLSNRLPQEIGLLKNLETIDLSYNAITNIASLSECPKLNSINVACNLLSFYEYSNPSATFIDFSFCPLTTIDPAFSYSNLVYFDISHAKLIGLKDSVIETLVNVETVKVNYNHFTSISDAISAMQNLKYLSCTNCEMSYVSPNLGKLKHLVHLDLHANNIKIFPEEVWQVSSLKVVNLSSNILEKIKLPVATSKKLTRTISQLKIMRTLSGNPVSSLSSQEFVMPTVEELYLVDNRLGNDCFTALEYFKCLKVLNLSYNYLTEIPSKFFQNFSDLKHLFVSGNELANLSISSTAQVLLETLYANGNRLSSFPKNEALSKSLRFLDISTNNLQNLAVEKAEKKSLTKLPQLEYLNLSGNTWFRFSEHEDTNFTKSYLKNLKFLSIMDLNTKFSNAPSDVLNHFIQRNSPQPNILRYGVCGYLSRSIPVISACELVVNNFLHPQSSLYCVLDSDISAGKNNRVLKFVYDNLASCLAHEINAADSSSEQICNALRRGFLRLNKKLGNVIHYDLRKSSEGDVDSNYVTTMNISEKGYSMDSSCLDIGVSIILVYVRDTRAFVANVGTSMAIMSTRNDSEPTTLSVMHDVYNRDEIRRIVDSCGFISGEIKSTTTRAIGRLSQFPGVQAVPYVNVQYLSELNEFIILANQEFWSVLSKRTVIDVVRANRHSPLLASTKLRDYAIAYGAEKNVLVVIVELNGLFEENSLNFNQLRGDEKTLAISEKNDNMSFVQDLPDDSSLARMNREVSPPKGCIAMVFTDIKNSTLLWERHPIAMRSAIKTHNTIMRRQLRATGGYEVKTEGDAFMVCFQTVPAALLWCFSVQLQLLSADWPNEIVESVQGRLVLGSKNEVLYRGLSVRIGVNYGVTVSELDPITRRMDYYGPVVNRTSRVVSVADGGQIAVSAEVVSVLNQLDSETMSSEKTNVNEMEVRALKQIGYIIHNLGEFKLKGLDTTEMISLVYPVQLQGRLERLIKSRSLGTPTALPETQTYTPVRSRSNSLRPMLARLSDSKSVHGEEGGSGKRSVSSLRNVSPSESTGGYEGCIFDDQQYQLLYELCERLEDHAAILHGFPEPPPCDTGLAAPVNQAEEYSLFYRLTLRIENTIYCVSQMLGHTG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
79PhosphorylationRPVEAFKTYPSTPAV
CCCCHHHCCCCCCCC		33.9224763107
83PhosphorylationAFKTYPSTPAVPSKS
HHHCCCCCCCCCCCE		15.6824763107
110PhosphorylationSLSDTGRTKSDTALA
CCCCCCCCHHHHHHH		35.9229996109
112PhosphorylationSDTGRTKSDTALAAR
CCCCCCHHHHHHHHH		39.3124763107
165PhosphorylationLIDKDRESFDKNLNQ
HHHCCHHHHHHHHCH		39.3729996109
173PhosphorylationFDKNLNQSFTNLTFP
HHHHHCHHHHCCCCC		32.7225720772
175PhosphorylationKNLNQSFTNLTFPEP
HHHCHHHHCCCCCCC		34.2727738172
204PhosphorylationLNNNWPASLEGSIHE
CCCCCCHHHCCCEEE		23.9129996109
208PhosphorylationWPASLEGSIHELPRN
CCHHHCCCEEECCCC		16.0529996109
216PhosphorylationIHELPRNSDDDGIPA
EEECCCCCCCCCCCH		43.6329996109
250PhosphorylationKKFLPYPSILSDDSW
HHHCCCCCCCCCCCC		30.2529996109
253PhosphorylationLPYPSILSDDSWKAP
CCCCCCCCCCCCCCC		37.3921712547
256PhosphorylationPSILSDDSWKAPESW
CCCCCCCCCCCCCCC		35.1524763107
262PhosphorylationDSWKAPESWGTSLPT
CCCCCCCCCCCCCCC		29.7324763107
286PhosphorylationTRFFARPSLGNRKKE
EEEECCCCCCCCCEE		43.2725720772
782PhosphorylationKKLTRTISQLKIMRT
HHHHHHHHHHHHHHH		28.9324763107
1424PhosphorylationQGRLVLGSKNEVLYR
CCEEECCCCCCEEEC		28.3125720772
1430PhosphorylationGSKNEVLYRGLSVRI
CCCCCEEECCCEEEE		14.0725720772
1568PhosphorylationLPETQTYTPVRSRSN
CCCCCCCCCCCCCCC		20.7829996109
1572PhosphorylationQTYTPVRSRSNSLRP
CCCCCCCCCCCCHHH		40.0525720772
1574PhosphorylationYTPVRSRSNSLRPML
CCCCCCCCCCHHHHH		31.8329996109
1576PhosphorylationPVRSRSNSLRPMLAR
CCCCCCCCHHHHHHH		27.3129996109
1589PhosphorylationARLSDSKSVHGEEGG
HHHCCCCCCCCCCCC		24.2521712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CYAA_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CYAA_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CYAA_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GIT1_SCHPOgit1genetic
16489217
SDS23_SCHPOsds23genetic
16273369
SXA2_SCHPOsxa2genetic
8314086
SCK1_SCHPOsck1genetic
7498728
WIS1_SCHPOwis1genetic
15189983
HOG1_SCHPOsty1genetic
15189983
PDE1_SCHPOcgs2genetic
16143612
KAPB_SCHPOpka1genetic
16143612
PYP1_SCHPOpyp1genetic
16143612
HOG1_SCHPOsty1genetic
16143612
ESC1_SCHPOesc1genetic
16143612
MCS4_SCHPOmcs4genetic
16143612
SCK2_SCHPOsck2genetic
16143612
GIT1_SCHPOgit1physical
16489217
GPA2_SCHPOgpa2physical
15925945
TOR2_SCHPOtor2genetic
20634885
PYP1_SCHPOpyp1genetic
8832414
PYP2_SCHPOpyp2genetic
8832414
KAPR_SCHPOcgs1genetic
15189983
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CYAA_SCHPO

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Related Literatures of Post-Translational Modification

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