CLNK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLNK_HUMAN
• UniProt AC: Q7Z7G1
• Protein Name: Cytokine-dependent hematopoietic cell linker
• Gene Name: CLNK
• Organism: Homo sapiens (Human).
• Sequence Length: 428
• Protein Description: Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT (By similarity)..
• Protein Sequence: MNRQGNRKTTKEGSNDLKFQNFSLPKNRSWPRINSATGQYQRMNKPLLDWERNFAAVLDGAKGHSDDDYDDPELRMEETWQSIKILPARPIKESEYADTHYFKVAMDTPLPLDTRTSISIGQPTWNTQTRLERVDKPISKDVRSQNIKGDASVRKNKIPLPPPRPLITLPKKYQPLPPEPESSRPPLSQRHTFPEVQRMPSQISLRDLSEVLEAEKVPHNQRKPESTHLLENQNTQEIPLAISSSSFTTSNHSVQNRDHRGGMQPCSPQRCQPPASCSPHENILPYKYTSWRPPFPKRSDRKDVQHNEWYIGEYSRQAVEEAFMKENKDGSFLVRDCSTKSKEEPYVLAVFYENKVYNVKIRFLERNQQFALGTGLRGDEKFDSVEDIIEHYKNFPIILIDGKDKTGVHRKQCHLTQPLPLTRHLLPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	DLKFQNFSLPKNRSW CCCCCCCCCCCCCCC	51.84	24719451
29	Phosphorylation	FSLPKNRSWPRINSA CCCCCCCCCCCHHHC	51.32	24719451
40	Phosphorylation	INSATGQYQRMNKPL HHHCCCCHHCCCCCC	10.22	-
65	Phosphorylation	LDGAKGHSDDDYDDP HCCCCCCCCCCCCCH	51.94	30108239
69	Phosphorylation	KGHSDDDYDDPELRM CCCCCCCCCCHHHCH	29.28	28122231
96	Phosphorylation	RPIKESEYADTHYFK CCCCHHHCCCCEEEE	21.03	-
116	Phosphorylation	PLPLDTRTSISIGQP CCCCCCCCEEEECCC	32.29	-
117	Phosphorylation	LPLDTRTSISIGQPT CCCCCCCEEEECCCC	15.85	-
119	Phosphorylation	LDTRTSISIGQPTWN CCCCCEEEECCCCCC	22.04	22468782
127	Phosphorylation	IGQPTWNTQTRLERV ECCCCCCCCHHHHHC	23.91	22468782
192	Phosphorylation	PPLSQRHTFPEVQRM CCCHHHCCCHHHHCC	42.97	30108239
204	Phosphorylation	QRMPSQISLRDLSEV HCCCCCCCHHHHHHH	15.09	24719451
331	Phosphorylation	MKENKDGSFLVRDCS HHHCCCCCEEEEECC	26.07	28857561
338	Phosphorylation	SFLVRDCSTKSKEEP CEEEEECCCCCCCCC	43.06	22817900
339	Phosphorylation	FLVRDCSTKSKEEPY EEEEECCCCCCCCCE	45.74	22817900
341	Phosphorylation	VRDCSTKSKEEPYVL EEECCCCCCCCCEEE	45.44	22817900
352	Phosphorylation	PYVLAVFYENKVYNV CEEEEEEECCEEEEE	16.40	22817900
357	Phosphorylation	VFYENKVYNVKIRFL EEECCEEEEEEEEEH	18.82	22817900
403	Acetylation	PIILIDGKDKTGVHR CEEEECCCCCCCCCC	52.91	7708367
405	Acetylation	ILIDGKDKTGVHRKQ EEECCCCCCCCCCCC	51.14	7708377
411	Acetylation	DKTGVHRKQCHLTQP CCCCCCCCCCCCCCC	42.26	7708387

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
69	Y	Phosphorylation	Kinase	LYN	P07948	Uniprot
96	Y	Phosphorylation	Kinase	LYN	P07948	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLNK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLNK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
F217A_HUMAN	FAM217A	physical	25814554
GLIS3_HUMAN	GLIS3	physical	25814554
ARAP3_HUMAN	ARAP3	physical	25814554
COQ9_HUMAN	COQ9	physical	25814554
C56D2_HUMAN	CYB561D2	physical	25814554
NDKM_HUMAN	NME4	physical	25814554
P85A_HUMAN	PIK3R1	physical	25814554
P55G_HUMAN	PIK3R3	physical	25814554
PP1R7_HUMAN	PPP1R7	physical	25814554
PTK7_HUMAN	PTK7	physical	25814554
RIP_HUMAN	RPAIN	physical	25814554
SMBT1_HUMAN	SFMBT1	physical	25814554
SOCS6_HUMAN	SOCS6	physical	25814554
ANR50_HUMAN	ANKRD50	physical	25814554
BMX_HUMAN	BMX	physical	25814554
CRK_HUMAN	CRK	physical	25814554
GRB2_HUMAN	GRB2	physical	25814554
GSTCD_HUMAN	GSTCD	physical	25814554
P4HA2_HUMAN	P4HA2	physical	25814554
PACN3_HUMAN	PACSIN3	physical	25814554
RASF1_HUMAN	RASSF1	physical	25814554
RB_HUMAN	RB1	physical	25814554
SMRD1_HUMAN	SMARCD1	physical	25814554
STK36_HUMAN	STK36	physical	25814554
TXK_HUMAN	TXK	physical	25814554
WWOX_HUMAN	WWOX	physical	25814554

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.