ARAP3_HUMAN - dbPTM
ARAP3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARAP3_HUMAN
UniProt AC Q8WWN8
Protein Name Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
Gene Name ARAP3
Organism Homo sapiens (Human).
Sequence Length 1544
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane
Peripheral membrane protein. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia..
Protein Description Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin..
Protein Sequence MAAPQDLDIAVWLATVHLEQYADTFRRHGLATAGAARGLGHEELKQLGISATGHRKRILRLLQTGTEEGSLDPKSDSAMEPSPSPAPQAQPPKPVPKPRTVFGGLSGPATTQRPGLSPALGGPGVSRSPEPSPRPPPLPTSSSEQSSALNTVEMMPNSIYFGLDSRGRAQAAQDKAPDSSQISAPTPALRPTTGTVHIMDPGCLYYGVQPVGTPGAPDRRESRGVCQGRAEHRLSRQDLEAREDAGYASLELPGDSTLLSPTLETEETSDDLISPYASFSFTADRLTPLLSGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQRLLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHPQYPDHSQLLQALCAAVARPNLLKNMTQLLCVEAFEGEEPWFPPAPDGSCPGLLPSDPSPGVYNEVVVRATYSGFLYCSPVSNKAGPSPPRRGRDAPPRLWCVLGAALEMFASENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGTDGADSLEAWTSAVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRGDHLFLCSAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFTAWNAAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLSQAGDLIMEVYIEQQLPDNCVTLKVSPTLTAEELTNQVLEMRGTAAGMDLWVTFEIREHGELERPLHPKEKVLEQALQWCQLPEPCSASLLLKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLGSRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLILEKMHLYLSCTDEDEMWDWTTSILKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRTLSMFFPMKSSQGSVEEQEELEEPVYEEPVYEEVGAFPELIQDTSTSFSTTREWTVKPENPLTSQKSLDQPFLSKSSTLGQEERPPEPPPGPPSKSSPQARGSLEEQLLQELSSLILRKGETTAGLGSPSQPSSPQSPSPTGLPTQTPGFPTQPPCTSSPPSSQPLT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationDIAVWLATVHLEQYA
HHHHHHHHHCHHHHH		13.2924043423
21PhosphorylationATVHLEQYADTFRRH
HHHCHHHHHHHHHHH		9.3224043423
24PhosphorylationHLEQYADTFRRHGLA
CHHHHHHHHHHHCHH		15.7424043423
32PhosphorylationFRRHGLATAGAARGL
HHHHCHHHHHHHCCC		30.5724043423
100PhosphorylationKPVPKPRTVFGGLSG
CCCCCCCEEECCCCC		28.8123312004
106PhosphorylationRTVFGGLSGPATTQR
CEEECCCCCCCCCCC		46.1123312004
110PhosphorylationGGLSGPATTQRPGLS
CCCCCCCCCCCCCCC		26.9623312004
111PhosphorylationGLSGPATTQRPGLSP
CCCCCCCCCCCCCCH		25.3725627689
117PhosphorylationTTQRPGLSPALGGPG
CCCCCCCCHHHCCCC		17.6523312004
126PhosphorylationALGGPGVSRSPEPSP
HHCCCCCCCCCCCCC		32.7223312004
128PhosphorylationGGPGVSRSPEPSPRP
CCCCCCCCCCCCCCC		26.5528355574
132PhosphorylationVSRSPEPSPRPPPLP
CCCCCCCCCCCCCCC		31.7023312004
160PhosphorylationEMMPNSIYFGLDSRG
ECCCCEEEECCCHHH		7.4527259358
179PhosphorylationAQDKAPDSSQISAPT
HHHCCCCHHHCCCCC		24.0821945579
180PhosphorylationQDKAPDSSQISAPTP
HHCCCCHHHCCCCCC		38.6221945579
183PhosphorylationAPDSSQISAPTPALR
CCCHHHCCCCCCCCC		22.1321945579
186PhosphorylationSSQISAPTPALRPTT
HHHCCCCCCCCCCCC		22.4021945579
192PhosphorylationPTPALRPTTGTVHIM
CCCCCCCCCCEEEEC		31.2721945579
193PhosphorylationTPALRPTTGTVHIMD
CCCCCCCCCEEEECC		33.2721945579
195PhosphorylationALRPTTGTVHIMDPG
CCCCCCCEEEECCCC		13.5621945579
205PhosphorylationIMDPGCLYYGVQPVG
ECCCCCEEEEEECCC		11.4021945579
206PhosphorylationMDPGCLYYGVQPVGT
CCCCCEEEEEECCCC		9.6221945579
213PhosphorylationYGVQPVGTPGAPDRR
EEEECCCCCCCCCCH		20.8421945579
235PhosphorylationGRAEHRLSRQDLEAR
HHHHHHCCHHHHHHH		28.0523403867
247PhosphorylationEAREDAGYASLELPG
HHHHHHCCCCEECCC		8.5022817900
296UbiquitinationLLSGWLDKLSPQGNY
HHHHHHHHHCCCCCE		49.01-
298PhosphorylationSGWLDKLSPQGNYVF
HHHHHHHCCCCCEEE		22.4021945579
303PhosphorylationKLSPQGNYVFQRRFV
HHCCCCCEEEEEEEE		14.9521945579
316PhosphorylationFVQFNGRSLMYFGSD
EEEECCEEEEEECCC		20.9123186163
319PhosphorylationFNGRSLMYFGSDKDP
ECCEEEEEECCCCCC		15.3022817900
322PhosphorylationRSLMYFGSDKDPFPK
EEEEEECCCCCCCCC		31.43-
353UbiquitinationNKFQVITGQRVFVFR
CCEEEEECCEEEEEE		11.37-
361PhosphorylationQRVFVFRTESEAQRD
CEEEEEECCCHHHHH		32.1922210691
363PhosphorylationVFVFRTESEAQRDMW
EEEEECCCHHHHHHH		37.3022210691
379UbiquitinationSTLQSCLKEQRLLGH
HHHHHHHHHHHHHCC		57.01-
409UbiquitinationELRGHKAKVFAALSP
EECCCCEEEEEEECH		42.56-
415PhosphorylationAKVFAALSPGELALY
EEEEEEECHHHHHEE		26.57-
422PhosphorylationSPGELALYKSEQAFS
CHHHHHEEECHHHHH		13.58-
443PhosphorylationFIELQGCSVRETKSR
EEEECCCCHHCCCCC		30.91-
540UbiquitinationALGSGISKVQSLKLD
HCCCCCCHHHCCCCC		42.23-
598PhosphorylationGEFISRKYRLGLFRK
CCCCCHHHHCCCCCC		15.2329396449
670PhosphorylationSDPSPGVYNEVVVRA
CCCCCCCCCEEEEEE		16.12-
684PhosphorylationATYSGFLYCSPVSNK
EEECCEEEEECCCCC		6.6622817900
686PhosphorylationYSGFLYCSPVSNKAG
ECCEEEEECCCCCCC		18.12-
695PhosphorylationVSNKAGPSPPRRGRD
CCCCCCCCCCCCCCC		46.7730266825
858PhosphorylationLRRLQEISVVSAADT
HHHHHEEEEEECCCC		18.7329396449
861PhosphorylationLQEISVVSAADTPDK
HHEEEEEECCCCCCC		18.6429396449
865PhosphorylationSVVSAADTPDKKEHL
EEEECCCCCCCCCCE		28.7621815630
882PhosphorylationVETGRTLYLQGEGRL
EEECCEEEEECCCCC		9.0722817900
941PhosphorylationGLRLEGVYRKGGARA
CCCEEEEECCCCHHH		19.9123917254
977PhosphorylationEHFVEDVTDTLKRFF
CHHHHHHHHHHHHHH		35.27-
979PhosphorylationFVEDVTDTLKRFFRE
HHHHHHHHHHHHHHH		25.47-
1009UbiquitinationEAAELPQKNQRLEKY
HHHHCCHHHHHHHHH		53.78-
1016PhosphorylationKNQRLEKYKDVIGCL
HHHHHHHHHHHHHCH		11.75-
1182UbiquitinationLERPLHPKEKVLEQA
CCCCCCCCHHHHHHH		60.46-
1184UbiquitinationRPLHPKEKVLEQALQ
CCCCCCHHHHHHHHH		59.24-
1206UbiquitinationCSASLLLKKVPLAQA
CCHHHHHHHCCHHHC		52.25-
1224PhosphorylationFTGIRRESPRVGLLR
HHCCCCCCCCCEEEE		19.0525137130
1264PhosphorylationLLLKEKKSSKPEREW
HHHHHHCCCCCCCCC		55.4526330541
1265PhosphorylationLLKEKKSSKPEREWP
HHHHHCCCCCCCCCC		62.2026330541
1319PhosphorylationEMWDWTTSILKAQHD
HHCHHHHHHHHHCCC		20.6724719451
1337PhosphorylationPVVLRRHSSSDLARQ
CEEEEECCCHHHHHH		29.7120363803
1338PhosphorylationVVLRRHSSSDLARQK
EEEEECCCHHHHHHH		23.0320363803
1339PhosphorylationVLRRHSSSDLARQKF
EEEECCCHHHHHHHH		39.3927273156
1345UbiquitinationSSDLARQKFGTMPLL
CHHHHHHHHCCCCCE		39.96-
1348PhosphorylationLARQKFGTMPLLPIR
HHHHHHCCCCCEEEC		20.8129255136
1365PhosphorylationDSGATLLSANQTLRR
CCCCEEECHHHHHHH		28.4328555341
1369PhosphorylationTLLSANQTLRRLHNR
EEECHHHHHHHHHCC		23.2629255136
1378PhosphorylationRRLHNRRTLSMFFPM
HHHHCCCEEEEEEEC		21.6823403867
1380PhosphorylationLHNRRTLSMFFPMKS
HHCCCEEEEEEECCC		16.9623403867
1403PhosphorylationEELEEPVYEEPVYEE
HHHCCCCCCCCCHHH		25.8721076469
1408PhosphorylationPVYEEPVYEEVGAFP
CCCCCCCHHHHCCCH		19.6521076469
1432PhosphorylationFSTTREWTVKPENPL
CCCCCCEEECCCCCC		17.5623312004
1434UbiquitinationTTREWTVKPENPLTS
CCCCEEECCCCCCCC		38.96-
1440PhosphorylationVKPENPLTSQKSLDQ
ECCCCCCCCCCCCCC		30.3022210691
1441PhosphorylationKPENPLTSQKSLDQP
CCCCCCCCCCCCCCC		43.2123312004
1443UbiquitinationENPLTSQKSLDQPFL
CCCCCCCCCCCCCCC		53.40-
1444PhosphorylationNPLTSQKSLDQPFLS
CCCCCCCCCCCCCCC		29.5530266825
1451PhosphorylationSLDQPFLSKSSTLGQ
CCCCCCCCCCCCCCC		30.7623403867
1452UbiquitinationLDQPFLSKSSTLGQE
CCCCCCCCCCCCCCC		51.04-
1471PhosphorylationEPPPGPPSKSSPQAR
CCCCCCCCCCCHHHC		48.5923403867
1472UbiquitinationPPPGPPSKSSPQARG
CCCCCCCCCCHHHCC		61.81-
1473PhosphorylationPPGPPSKSSPQARGS
CCCCCCCCCHHHCCC		52.1423927012
1474PhosphorylationPGPPSKSSPQARGSL
CCCCCCCCHHHCCCH		25.4323403867
1480PhosphorylationSSPQARGSLEEQLLQ
CCHHHCCCHHHHHHH		27.3611804589
1490PhosphorylationEQLLQELSSLILRKG
HHHHHHHHHHHHHCC		23.5027732954
1491PhosphorylationQLLQELSSLILRKGE
HHHHHHHHHHHHCCC		31.8627732954
1507PhosphorylationTAGLGSPSQPSSPQS
CCCCCCCCCCCCCCC		57.32-
1511PhosphorylationGSPSQPSSPQSPSPT
CCCCCCCCCCCCCCC		33.37-
1514PhosphorylationSQPSSPQSPSPTGLP
CCCCCCCCCCCCCCC		30.63-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARAP3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARAP3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARAP3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SH3K1_HUMANSH3KBP1physical
15090612
ASAP1_HUMANASAP1physical
15090612
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARAP3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1444, AND MASSSPECTROMETRY.

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