CDCA5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDCA5_MOUSE
• UniProt AC: Q9CPY3
• Protein Name: Sororin
• Gene Name: Cdca5
• Organism: Mus musculus (Mouse).
• Sequence Length: 264
• Subcellular Localization: Nucleus . Chromosome . Cytoplasm . Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.
• Protein Description: Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair..
• Protein Sequence: MAERRTRSGGAAQRSGPRTSLTKPSKSSKRKSGSDLPNSFSEIWPRTTPAVPVRKAIVLKKIVAHAVEVPDVHTVRRSPRISFILEKENNPPLKVPTKEDLFKTCSVPGTPSSTPVLYTQNVEPDSGEAELDSRDLEMSQKVRRSYSRLQSLGCASTSTPGRRSFFGFEGPDDLPGVSPVVCSKLIETPKVPAKDLVPARTKDLVPDSTKDLVPARTLPGISPPVVKEKRKKKVPEILKSELDKWAVAMNAEFEAAEQFELLIE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	SGGAAQRSGPRTSLT CCCCCCCCCCCCCCC	40.86	28059163
20	Phosphorylation	QRSGPRTSLTKPSKS CCCCCCCCCCCCCCC	35.01	22067460
32	Phosphorylation	SKSSKRKSGSDLPNS CCCCCCCCCCCCCCC	47.78	26745281
34	Phosphorylation	SSKRKSGSDLPNSFS CCCCCCCCCCCCCHH	42.96	25266776
39	Phosphorylation	SGSDLPNSFSEIWPR CCCCCCCCHHHHCCC	28.36	26745281
74	Phosphorylation	VEVPDVHTVRRSPRI CCCCCHHCCCCCCCE	18.63	26643407
78	Phosphorylation	DVHTVRRSPRISFIL CHHCCCCCCCEEEEE	14.15	26745281
82	Phosphorylation	VRRSPRISFILEKEN CCCCCCEEEEEECCC	13.91	26745281
97	Phosphorylation	NPPLKVPTKEDLFKT CCCCCCCCHHHHHHH	50.48	-
106	Phosphorylation	EDLFKTCSVPGTPSS HHHHHHCCCCCCCCC	36.26	-
110	Phosphorylation	KTCSVPGTPSSTPVL HHCCCCCCCCCCCEE	17.58	-
114	Phosphorylation	VPGTPSSTPVLYTQN CCCCCCCCCEEEECC	23.04	-
118	Phosphorylation	PSSTPVLYTQNVEPD CCCCCEEEECCCCCC	13.40	-
126	Phosphorylation	TQNVEPDSGEAELDS ECCCCCCCCCEECCH	49.61	22067460
133	Phosphorylation	SGEAELDSRDLEMSQ CCCEECCHHHHHHHH	40.08	-
139	Phosphorylation	DSRDLEMSQKVRRSY CHHHHHHHHHHHHHH	19.92	22006019
145	Phosphorylation	MSQKVRRSYSRLQSL HHHHHHHHHHHHHHH	19.52	23737553
146	Phosphorylation	SQKVRRSYSRLQSLG HHHHHHHHHHHHHHC	8.94	23737553
147	Phosphorylation	QKVRRSYSRLQSLGC HHHHHHHHHHHHHCC	27.97	23737553
151	Phosphorylation	RSYSRLQSLGCASTS HHHHHHHHHCCCCCC	31.18	26745281
156	Phosphorylation	LQSLGCASTSTPGRR HHHHCCCCCCCCCCC	27.28	26745281
157	Phosphorylation	QSLGCASTSTPGRRS HHHCCCCCCCCCCCC	20.35	26745281
158	Phosphorylation	SLGCASTSTPGRRSF HHCCCCCCCCCCCCC	30.06	26745281
159	Phosphorylation	LGCASTSTPGRRSFF HCCCCCCCCCCCCCC	29.83	26745281
164	Phosphorylation	TSTPGRRSFFGFEGP CCCCCCCCCCCCCCC	24.46	26643407
178	Phosphorylation	PDDLPGVSPVVCSKL CCCCCCCCCEEEHHH	20.21	26745281
183	Phosphorylation	GVSPVVCSKLIETPK CCCCEEEHHHCCCCC	20.91	26643407
188	Phosphorylation	VCSKLIETPKVPAKD EEHHHCCCCCCCHHH	22.78	22067460
201	Phosphorylation	KDLVPARTKDLVPDS HHCCCCCCCCCCCCC	30.89	-
222	Phosphorylation	ARTLPGISPPVVKEK CCCCCCCCCCHHHHH	29.12	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDCA5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDCA5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDCA5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDS5B_HUMAN	PDS5B	physical	20360068
STAG2_HUMAN	STAG2	physical	20360068
AURKB_HUMAN	AURKB	physical	20360068
SMC3_HUMAN	SMC3	physical	20360068
RAD21_HUMAN	RAD21	physical	20360068
SMC1A_HUMAN	SMC1A	physical	20360068
LCN1_HUMAN	LCN1	physical	20360068
RAD21_HUMAN	RAD21	physical	26496610
ZN177_HUMAN	ZNF177	physical	26496610
SMC1A_HUMAN	SMC1A	physical	26496610
ADAS_HUMAN	AGPS	physical	26496610
SMC3_HUMAN	SMC3	physical	26496610
REPS2_HUMAN	REPS2	physical	26496610
ATPK_HUMAN	ATP5J2	physical	26496610
STAG1_HUMAN	STAG1	physical	26496610
PRDX4_HUMAN	PRDX4	physical	26496610
STAG2_HUMAN	STAG2	physical	26496610
SF3B2_HUMAN	SF3B2	physical	26496610
PLPHP_HUMAN	PROSC	physical	26496610
PDS5B_HUMAN	PDS5B	physical	26496610
PPIL3_HUMAN	PPIL3	physical	26496610
CHD9_HUMAN	CHD9	physical	26496610
RM55_HUMAN	MRPL55	physical	26496610
CPNE2_HUMAN	CPNE2	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.