ZNT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNT4_HUMAN
• UniProt AC: O14863
• Protein Name: Zinc transporter 4
• Gene Name: SLC30A4
• Organism: Homo sapiens (Human).
• Sequence Length: 429
• Subcellular Localization: Endosome membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein .
• Protein Description: Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment..
• Protein Sequence: MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEAGDEGLSRFNKLRVVVADDGSEAPERPVNGAHPTLQADDDSLLDQDLPLTNSQLSLKVDSCDNCSKQREILKQRKVKARLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQRTIHMNYEINGDIMLITAAVGVAVNVIMGFLLNQSGHRHSHSHSLPSNSPTRGSGCERNHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALMKIEDVYSVEDLNIWSLTSGKSTAIVHIQLIPGSSSKWEEVQSKANHLLLNTFGMYRCTIQLQSYRQEVDRTCANCQSSSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	GAWKRLKSMLRKDDA HHHHHHHHHHCCCCC	27.86	-
55	Phosphorylation	VVVADDGSEAPERPV EEECCCCCCCCCCCC	37.26	28787133
68	Phosphorylation	PVNGAHPTLQADDDS CCCCCCCCCCCCCCC	22.95	28787133
75	Phosphorylation	TLQADDDSLLDQDLP CCCCCCCCCCCCCCC	37.51	28787133
84	Phosphorylation	LDQDLPLTNSQLSLK CCCCCCCCCCCEEEE	30.77	26471730
86	Phosphorylation	QDLPLTNSQLSLKVD CCCCCCCCCEEEEEE	27.54	26471730
106	Ubiquitination	SKQREILKQRKVKAR HHHHHHHHHHHHHHH	54.43	29967540
309	Phosphorylation	KIADPICTYVFSLLV CCCHHHHHHHHHHHH	24.36	25404012
313	Phosphorylation	PICTYVFSLLVAFTT HHHHHHHHHHHHHHH	15.68	-
319	Phosphorylation	FSLLVAFTTFRIIWD HHHHHHHHHHHHHHC	18.45	25404012
384	Phosphorylation	QLIPGSSSKWEEVQS EECCCCCHHHHHHHH	43.41	22496350
412	Phosphorylation	RCTIQLQSYRQEVDR EEEEEHHHHHHHHHH	30.76	-
428	Phosphorylation	CANCQSSSP------ HHHCCCCCC------	39.62	22617229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZNT4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNT4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CIAO1_HUMAN	CIAO1	physical	26186194
YES_HUMAN	YES1	physical	26186194
BLK_HUMAN	BLK	physical	26186194
NCAM1_HUMAN	NCAM1	physical	26186194
COL12_HUMAN	COLEC12	physical	26186194
IF5_HUMAN	EIF5	physical	26186194
GNAO_HUMAN	GNAO1	physical	26186194
RBM25_HUMAN	RBM25	physical	26186194
RAP2A_HUMAN	RAP2A	physical	26186194
PDS5B_HUMAN	PDS5B	physical	26186194
PDS5A_HUMAN	PDS5A	physical	26186194
SNAA_HUMAN	NAPA	physical	26186194
NOP9_HUMAN	NOP9	physical	26186194
PR40A_HUMAN	PRPF40A	physical	26186194
CIP2A_HUMAN	KIAA1524	physical	26186194
GBB4_HUMAN	GNB4	physical	26186194
HBD_HUMAN	HBD	physical	26186194
CS025_HUMAN	C19orf25	physical	26186194
CSTF2_HUMAN	CSTF2	physical	26186194
PDS5B_HUMAN	PDS5B	physical	28514442
RBM25_HUMAN	RBM25	physical	28514442
PR40A_HUMAN	PRPF40A	physical	28514442
JIP4_HUMAN	SPAG9	physical	28514442
PDS5A_HUMAN	PDS5A	physical	28514442
CS025_HUMAN	C19orf25	physical	28514442
IF5_HUMAN	EIF5	physical	28514442
COL12_HUMAN	COLEC12	physical	28514442
NCAM1_HUMAN	NCAM1	physical	28514442
LST8_HUMAN	MLST8	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.