TRHDE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRHDE_HUMAN
• UniProt AC: Q9UKU6
• Protein Name: Thyrotropin-releasing hormone-degrading ectoenzyme
• Gene Name: TRHDE
• Organism: Homo sapiens (Human).
• Sequence Length: 1024
• Subcellular Localization: Membrane; Single-pass type II membrane protein.
• Protein Description: Specific inactivation of TRH after its release..
• Protein Sequence: MGEDDAALRAGSRGLSDPWADSVGVRPRTTERHIAVHKRLVLAFAVSLVALLAVTMLAVLLSLRFDECGASATPGADGGPSGFPERGGNGSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQLAEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIYNALIENELLGFFRSSYVLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKNYDGVAAASFSRAVETVEANVRWKMLYQDELFQWLGKALRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LSDPWADSVGVRPRT CCCCCHHHCCCCCCC	17.02	-
89	N-linked_Glycosylation	GFPERGGNGSLPGSA CCCCCCCCCCCCCCC	39.44	UniProtKB CARBOHYD
91	Phosphorylation	PERGGNGSLPGSARR CCCCCCCCCCCCCCC	35.08	-
95	Phosphorylation	GNGSLPGSARRNHHA CCCCCCCCCCCCCCC	19.36	-
121	O-linked_Glycosylation	VASPGTTSAQPPSEE CCCCCCCCCCCCCHH	25.41	OGP
160	N-linked_Glycosylation	MLTAFMENFTFSGEV HHHHHHHCCEECCEE	29.48	UniProtKB CARBOHYD
175	N-linked_Glycosylation	NVEIACRNATRYVVL EEEEEECCCCEEEEE	45.61	UniProtKB CARBOHYD
222	N-linked_Glycosylation	QVLVVVLNRTLDAQR EEEEEEEECCCCHHH	24.23	UniProtKB CARBOHYD
338	N-linked_Glycosylation	YLAWAICNFTYRETT HHHHHHHCCCCCCCC	26.61	UniProtKB CARBOHYD
365	Phosphorylation	PDAIRRGSGDYALHI CHHHHCCCCCHHHHH	27.04	24961811
373	Phosphorylation	GDYALHITKRLIEFY CCHHHHHHHHHHHHH	10.20	-
605	N-linked_Glycosylation	PVITILGNTTAENRI CEEEEECCCCCCCCE	30.70	UniProtKB CARBOHYD
615	Phosphorylation	AENRIIITQQHFIYD CCCCEEEEECEEEEE	16.27	24043423
621	Phosphorylation	ITQQHFIYDISAKTK EEECEEEEECCHHCC	13.28	24043423
624	Phosphorylation	QHFIYDISAKTKALK CEEEEECCHHCCEEE	22.33	24043423
634	N-linked_Glycosylation	TKALKLQNNSYLWQI CCEEECCCCCEEEEE	50.26	UniProtKB CARBOHYD
649	N-linked_Glycosylation	PLTIVVGNRSHVSSE EEEEEECCCCCCCCE	30.58	UniProtKB CARBOHYD
663	N-linked_Glycosylation	EAIIWVSNKSEHHRI EEEEEECCCCCCCEE	42.10	UniProtKB CARBOHYD
684	N-linked_Glycosylation	SWLLGNINQTGYFRV CEEECCCCCCCEEEE	37.04	UniProtKB CARBOHYD
726	Phosphorylation	GLIDDAFSLARAGYL CCHHHHHHHHHCCCC	23.88	22964224
787	Phosphorylation	YILKQVATTYIKLGW HHHHHHHHHHHHCCC	22.67	28509920
788	Phosphorylation	ILKQVATTYIKLGWP HHHHHHHHHHHCCCC	17.32	28509920
789	Phosphorylation	LKQVATTYIKLGWPK HHHHHHHHHHCCCCC	7.54	28509920
800	N-linked_Glycosylation	GWPKNNFNGSLVQAS CCCCCCCCCCCCCHH	41.07	UniProtKB CARBOHYD
857	Phosphorylation	LNVRDIVYCTGVSLL CCHHHHEEEECCCCC	5.66	-
859	Phosphorylation	VRDIVYCTGVSLLDE HHHHEEEECCCCCCH	23.96	-
862	Phosphorylation	IVYCTGVSLLDEDVW HEEEECCCCCCHHHH	25.26	-
906	N-linked_Glycosylation	NLLNRLLNLSLNSEV HHHHHHHHHCCCCCE	31.98	UniProtKB CARBOHYD
949	O-linked_Glycosylation	DKWKILNTRYGEALF HHHHHHHCHHHHHHH	23.09	30379171
992	Phosphorylation	YDGVAAASFSRAVET CCHHHHHHHHHHHHH	21.01	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRHDE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRHDE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRHDE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MUL1_HUMAN	MUL1	physical	28514442
TSN3_HUMAN	TSPAN3	physical	28514442
DNJB9_HUMAN	DNAJB9	physical	28514442
MAN1_HUMAN	LEMD3	physical	28514442
EMIL2_HUMAN	EMILIN2	physical	28514442
MANEA_HUMAN	MANEA	physical	28514442
FKB14_HUMAN	FKBP14	physical	28514442
KIRR1_HUMAN	KIRREL	physical	28514442
CALX_HUMAN	CANX	physical	28514442
TMTC3_HUMAN	TMTC3	physical	28514442
MESD_HUMAN	MESDC2	physical	28514442
MA1A2_HUMAN	MAN1A2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.