THTPA_HUMAN - dbPTM
THTPA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THTPA_HUMAN
UniProt AC Q9BU02
Protein Name Thiamine-triphosphatase
Gene Name THTPA
Organism Homo sapiens (Human).
Sequence Length 230
Subcellular Localization Cytoplasm .
Protein Description Hydrolase highly specific for thiamine triphosphate (ThTP)..
Protein Sequence MAQGLIEVERKFLPGPGTEERLQELGGTLEYRVTFRDTYYDTPELSLMQADHWLRRREDSGWELKCPGAAGVLGPHTEYKELTAEPTIVAQLCKVLRADGLGAGDVAAVLGPLGLQEVASFVTKRSAWKLVLLGADEEEPQLRVDLDTADFGYAVGEVEALVHEEAEVPTALEKIHRLSSMLGVPAQETAPAKLIVYLQRFRPQDYQRLLEVNSSRERPQETEDPDHCLG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAQGLIEVE
------CCCCCEEEE		16.4922223895
11UbiquitinationGLIEVERKFLPGPGT
CCEEEEHHCCCCCCC		37.4321890473
18PhosphorylationKFLPGPGTEERLQEL
HCCCCCCCHHHHHHH		37.49-
31PhosphorylationELGGTLEYRVTFRDT
HHCCEEEEEEEECCC		17.3122817900
65UbiquitinationEDSGWELKCPGAAGV
CCCCCEEECCCCCCC		27.20-
124UbiquitinationEVASFVTKRSAWKLV
HHHHHHCHHHHHEEE		38.77-
174UbiquitinationEVPTALEKIHRLSSM
CCCHHHHHHHHHHHH		44.66-
179PhosphorylationLEKIHRLSSMLGVPA
HHHHHHHHHHHCCCH		17.4128857561
180PhosphorylationEKIHRLSSMLGVPAQ
HHHHHHHHHHCCCHH		23.7128857561
181SulfoxidationKIHRLSSMLGVPAQE
HHHHHHHHHCCCHHH		3.2021406390
193AcetylationAQETAPAKLIVYLQR
HHHCCCHHHHEEHHH		37.3723236377
193UbiquitinationAQETAPAKLIVYLQR
HHHCCCHHHHEEHHH		37.3721890473
206PhosphorylationQRFRPQDYQRLLEVN
HHCCHHHHHHHHHCC		7.1219664995
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THTPA_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THTPA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THTPA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBP5_HUMANUSP5physical
22939629
UBA5_HUMANUBA5physical
22939629
UBP7_HUMANUSP7physical
22939629
TRM1L_HUMANTRMT1Lphysical
22939629
DIM1_HUMANDIMT1physical
26186194
GTPB6_HUMANGTPBP6physical
26186194
ARMX3_HUMANARMCX3physical
26186194
CLPX_HUMANCLPXphysical
26186194
WDR59_HUMANWDR59physical
26186194
TBA1A_HUMANTUBA1Aphysical
26186194
ITIH3_HUMANITIH3physical
26186194
CLPX_HUMANCLPXphysical
28514442
ARF6_HUMANARF6physical
28514442
ITIH3_HUMANITIH3physical
28514442
RTL8C_HUMANFAM127Aphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THTPA_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory