T3HPD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T3HPD_HUMAN
• UniProt AC: Q96EM0
• Protein Name: Trans-3-hydroxy-L-proline dehydratase {ECO:0000303|PubMed:22528483, ECO:0000303|PubMed:24649405}
• Gene Name: L3HYPDH
• Organism: Homo sapiens (Human).
• Sequence Length: 354
• Protein Description: Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it..
• Protein Sequence: MESALAVPRLPPHDPGTPVLSVVDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYSSMCGHAVLALGRFALDFGLVPAPPAGTREARVNIHCPCGLVTAFVACEDGRSHGPVRFHSVPAFVLATDLMVDVPGHGKVMVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKEPTTNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQMRAFKSSATGSVFTGKAVREAKCGDFKAVIVEVSGQAHYTGTASFIIEDDDPLRDGFLLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESALAVPRL -----CCCCCCCCCC		24043423
17	Phosphorylation	LPPHDPGTPVLSVVD CCCCCCCCCEEEEEE		24043423
21	Phosphorylation	DPGTPVLSVVDMHTG CCCCCEEEEEECCCC		24043423
27	Phosphorylation	LSVVDMHTGGEPLRI EEEEECCCCCCEEEE		24043423
50	Ubiquitination	SGPTLLAKRRYMRQH CCHHHHHHHHHHHHH		33845483
50	2-Hydroxyisobutyrylation	SGPTLLAKRRYMRQH CCHHHHHHHHHHHHH		-
208	Ubiquitination	GLDICSAKTRDLVDA CCEECCCCHHHHHHH		29967540
249	Ubiquitination	GTILTDGKDAYTKEP EEEECCCCCCCCCCC		29967540
271	Phosphorylation	ADEQVDRSPTGSGVT ECCCCCCCCCCCCHH		-
273	Phosphorylation	EQVDRSPTGSGVTAR CCCCCCCCCCCHHHH		-
278	Phosphorylation	SPTGSGVTARIALQY CCCCCCHHHHHHHHH		-
299	Methylation	LNQMRAFKSSATGSV HHHHHHHHCCCCCCC		115972291
299	Ubiquitination	LNQMRAFKSSATGSV HHHHHHHHCCCCCCC		29967540
310	Ubiquitination	TGSVFTGKAVREAKC CCCCCCCHHHHEECC		29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T3HPD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T3HPD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T3HPD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDFY1_HUMAN	WDFY1	physical	22939629
AL7A1_HUMAN	ALDH7A1	physical	26186194
MUTA_HUMAN	MUT	physical	26186194
GSTK1_HUMAN	GSTK1	physical	26186194
UTRO_HUMAN	UTRN	physical	26186194
RDH13_HUMAN	RDH13	physical	26186194
CCNE2_HUMAN	CCNE2	physical	26186194
ACOT9_HUMAN	ACOT9	physical	26186194
CHK1_HUMAN	CHEK1	physical	26186194
DIXC1_HUMAN	DIXDC1	physical	26186194
KBRS2_HUMAN	NKIRAS2	physical	26186194
RPC3_HUMAN	POLR3C	physical	26186194
THUM3_HUMAN	THUMPD3	physical	26186194
CCNE2_HUMAN	CCNE2	physical	28514442
DIXC1_HUMAN	DIXDC1	physical	28514442
UTRO_HUMAN	UTRN	physical	28514442
AL7A1_HUMAN	ALDH7A1	physical	28514442
RPC3_HUMAN	POLR3C	physical	28514442
ACOT9_HUMAN	ACOT9	physical	28514442
RS14_HUMAN	RPS14	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.