NIA2_ARATH - dbPTM
NIA2_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NIA2_ARATH
UniProt AC P11035
Protein Name Nitrate reductase [NADH] 2
Gene Name NIA2
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 917
Subcellular Localization
Protein Description Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria..
Protein Sequence MAASVDNRQYARLEPGLNGVVRSYKPPVPGRSDSPKAHQNQTTNQTVFLKPAKVHDDDEDVSSEDENETHNSNAVYYKEMIRKSNAELEPSVLDPRDEYTADSWIERNPSMVRLTGKHPFNSEAPLNRLMHHGFITPVPLHYVRNHGHVPKAQWAEWTVEVTGFVKRPMKFTMDQLVSEFAYREFAATLVCAGNRRKEQNMVKKSKGFNWGSAGVSTSVWRGVPLCDVLRRCGIFSRKGGALNVCFEGSEDLPGGAGTAGSKYGTSIKKEYAMDPSRDIILAYMQNGEYLTPDHGFPVRIIIPGFIGGRMVKWLKRIIVTTKESDNFYHFKDNRVLPSLVDAELADEEGWWYKPEYIINELNINSVITTPCHEEILPINAFTTQRPYTLKGYAYSGGGKKVTRVEVTVDGGETWNVCALDHQEKPNKYGKFWCWCFWSLEVEVLDLLSAKEIAVRAWDETLNTQPEKMIWNLMGMMNNCWFRVKTNVCKPHKGEIGIVFEHPTLPGNESGGWMAKERHLEKSADAPPSLKKSVSTPFMNTTAKMYSMSEVKKHNSADSCWIIVHGHIYDCTRFLMDHPGGSDSILINAGTDCTEEFEAIHSDKAKKMLEDYRIGELITTGYSSDSSSPNNSVHGSSAVFSLLAPIGEATPVRNLALVNPRAKVPVQLVEKTSISHDVRKFRFALPVEDMVLGLPVGKHIFLCATINDKLCLRAYTPSSTVDVVGYFELVVKIYFGGVHPRFPNGGLMSQYLDSLPIGSTLEIKGPLGHVEYLGKGSFTVHGKPKFADKLAMLAGGTGITPVYQIIQAILKDPEDETEMYVIYANRTEEDILLREELDGWAEQYPDRLKVWYVVESAKEGWAYSTGFISEAIMREHIPDGLDGSALAMACGPPPMIQFAVQPNLEKMQYNIKEDFLIF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationGLNGVVRSYKPPVPG
CCCCCHHCCCCCCCC		26.3719880383
24PhosphorylationLNGVVRSYKPPVPGR
CCCCHHCCCCCCCCC		19.5625561503
32PhosphorylationKPPVPGRSDSPKAHQ
CCCCCCCCCCCCHHC		48.6423776212
34PhosphorylationPVPGRSDSPKAHQNQ
CCCCCCCCCCHHCCC		29.5523776212
42PhosphorylationPKAHQNQTTNQTVFL
CCHHCCCCCCCEEEE		34.9523776212
43PhosphorylationKAHQNQTTNQTVFLK
CHHCCCCCCCEEEEE		18.6323776212
46PhosphorylationQNQTTNQTVFLKPAK
CCCCCCCEEEEEECC		18.4623776212
62PhosphorylationHDDDEDVSSEDENET
CCCCCCCCCCCCCCC		40.0924601666
63PhosphorylationDDDEDVSSEDENETH
CCCCCCCCCCCCCCC		49.2524601666
69PhosphorylationSSEDENETHNSNAVY
CCCCCCCCCCCCHHH		37.6323776212
72PhosphorylationDENETHNSNAVYYKE
CCCCCCCCCHHHHHH		20.6823776212
76PhosphorylationTHNSNAVYYKEMIRK
CCCCCHHHHHHHHHH		13.3525368622
77PhosphorylationHNSNAVYYKEMIRKS
CCCCHHHHHHHHHHC		8.2225368622
110PhosphorylationSWIERNPSMVRLTGK
HHHHHCHHHEEECCC		33.2024894044
532PhosphorylationAPPSLKKSVSTPFMN
CCCHHHHHCCCCCCC		21.5119880383
534PhosphorylationPSLKKSVSTPFMNTT
CHHHHHCCCCCCCCC		37.1430291188
535PhosphorylationSLKKSVSTPFMNTTA
HHHHHCCCCCCCCCH		20.5624601666
538SulfoxidationKSVSTPFMNTTAKMY
HHCCCCCCCCCHHCC		4.6019527223
540PhosphorylationVSTPFMNTTAKMYSM
CCCCCCCCCHHCCCH		19.1523776212
541PhosphorylationSTPFMNTTAKMYSMS
CCCCCCCCHHCCCHH		21.1923776212
618PhosphorylationYRIGELITTGYSSDS
CCCCHHEEECCCCCC		27.1323776212
619PhosphorylationRIGELITTGYSSDSS
CCCHHEEECCCCCCC		27.4223776212
621PhosphorylationGELITTGYSSDSSSP
CHHEEECCCCCCCCC		11.6923776212
622PhosphorylationELITTGYSSDSSSPN
HHEEECCCCCCCCCC		29.0723776212
623PhosphorylationLITTGYSSDSSSPNN
HEEECCCCCCCCCCC		32.7823776212
625PhosphorylationTTGYSSDSSSPNNSV
EECCCCCCCCCCCCC		34.3623776212
626PhosphorylationTGYSSDSSSPNNSVH
ECCCCCCCCCCCCCC		55.6023776212
627PhosphorylationGYSSDSSSPNNSVHG
CCCCCCCCCCCCCCC		35.2823776212
631PhosphorylationDSSSPNNSVHGSSAV
CCCCCCCCCCCHHHH		23.3323776212
635PhosphorylationPNNSVHGSSAVFSLL
CCCCCCCHHHHHHHH		10.5523776212
636PhosphorylationNNSVHGSSAVFSLLA
CCCCCCHHHHHHHHC		32.8023776212
640PhosphorylationHGSSAVFSLLAPIGE
CCHHHHHHHHCCCCC		18.8423776212
649PhosphorylationLAPIGEATPVRNLAL
HCCCCCCCCCCCEEE		20.2923776212
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NIA2_ARATH !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NIA2_ARATH !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NIA2_ARATH !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
14339_ARATHGRF9physical
9933611
14336_ARATHGRF6physical
9933611
14338_ARATHGRF8physical
9933611
14332_ARATHGRF2physical
9933611
14333_ARATHGRF3physical
9933611
14331_ARATHGRF1physical
9933611
MPK3_ARATHMPK3physical
20870959
MPK6_ARATHMPK6physical
20870959
NIA2_ARATHNIA2physical
22170050
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NIA2_ARATH

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; SER-62; SER-63 ANDSER-534, AND MASS SPECTROMETRY.

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